Agallochins J-L, New Isopimarane Diterpenoids from Excoecaria Agallocha L

Anjaneyulu, A. S. R.; Rao, V. Pandu Ranga; Sreedhar, K.

doi:10.1080/1057563021000027975

Cited by 16 publications

(11 citation statements)

References 8 publications

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“…Chemical investigation of the roots of mangrove plant Excoecaria agallocha L., collected from the Godavari Estuary at 16°58 0 N, 82°15 0 E, led to the isolation of agallochins D (9) and agallochins J -L (11 -13) at the year of 2000 and 2003, respectively ( Figure 3). [8] [9] Meanwhile, a isopimarane diterpene, named rhizophorins E (10; Figure 3), was isolated from ethyl acetate extract of the roots of Rhizophora mucronata obtained from Mangalore Coast of India by the same research group. [10] Two isopimarane diterpenes, compounds 14 and 15 ( Figure 3) were isolated from the methanol extracts of the stems of mangrove plant Bruguiera gymnorrhiza, which were obtained from Xiamen of P. R. China.…”

Section: Isopimaranesmentioning

confidence: 99%

Bioactive Pimarane‐Type Diterpenes from Marine Organisms

Wang

Zhang

et al. 2017

Chemistry & Biodiversity

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Marine organisms represent an abundant sources of bioactive natural products with unique chemical structure. Pimarane diterpenes are a structurally diverse family of natural products with various biological activities and pharmacological properties. A prolific source of new marine-derived pimarane diterpenes have attracted considerable interest because of their unique structural diversity and varied biological activities, including antimicrobial, antitumor, and antiproliferative activities. This review provides a comprehensive overview of the structures, names, bioactivities, and references of 80 marine-derived pimarane-type natural products for the first time.

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Section: Isopimaranesmentioning

confidence: 99%

Bioactive Pimarane‐Type Diterpenes from Marine Organisms

Wang

Zhang

et al. 2017

Chemistry & Biodiversity

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“…More than 72 cytotoxic diterpenoids have been identified from E . agallocha , structurally belonging to labdane (Konishi et al, 1999 , 2003 ; Anjaneyulu and Rao, 2000 ; Annam et al, 2015 ), isopimarane/ ent -isopimarane (Anjaneyulu et al, 2003 ; Wang and Guo, 2004 ; Kang et al, 2005 ; Wang et al, 2005 ; Gowri Ponnapalli et al, 2013 ), atisane/ ent -atisane (Konishi et al, 2000 ; Wang et al, 2009 ), ent -kaurane (Anjaneyulu et al, 2002 ; Li et al, 2010 ), and beyerane-type (Anjaneyulu et al, 2002 ).…”

Section: Introductionmentioning

confidence: 99%

Polyketides From the Endophytic Fungus Cladosporium sp. Isolated From the Mangrove Plant Excoecaria agallocha

et al. 2018

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Five new polyketides (2–6) and ten known compounds (1 and 7–15) were obtained from the fermentation products of the endophytic fungus Cladosporium sp. OUCMDZ-302 with the mangrove plant, Excoecaria agallocha (Euphorbiaceae). The new structures of 2–6 were established on the basis of ECD, specific rotation and spectroscopic data as well as the chemical calculation. Compound 7 showed cytotoxicity against H1975 cell line with an IC50 value of 10.0 μM. Compounds 4 and 8–10 showed radical scavenging activity against DPPH with the IC50 values of 2.65, 0.24, 5.66, and 6.67 μM, respectively. In addition, the absolute configuration of compound 1 was solidly determined by X-ray and sugar analysis of the acidic hydrolysates for the first time as well as those of compounds 8–10 in this paper.

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“…[822232425262728293031323334353637383940414243444546474849505152535455] The details of their names are given in Table 5. The chemical structures of some isolated compounds are given in Figure 2.…”

Section: Introductionmentioning

confidence: 99%

“…[222432353435363738] Roots yielded four isopimarane diterpenes 42–45,[2235] five isopimarane diterpenes 47–51 were isolated from stems and leaves,[3637] compounds 46 and 53–55 were isolated from woods,[2438] and compound 52 was isolated from the whole plant. [32] Two isopiramane diterpenes 53 and 54 contains a seven membered lactone moieties.…”

Section: Introductionmentioning

confidence: 99%

A complete profile on blind-your-eye mangrove Excoecaria agallocha L. (Euphorbiaceae): Ethnobotany, phytochemistry, and pharmacological aspects

Mondal¹,

Ghosh²,

Ramakrishna³

2016

Phcog Rev

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Traditional system of medicine consists of large number of plants with various medicinal and pharmacological importances. This article provides a comprehensive review of the complete profile of an important mangrove plant Excoecaria agallocha L. (Euphorbiaceae) and elaborately describing the ethnobotany, phytochemistry, and pharmacological properties. It is used traditionally in the treatment of various diseases such as epilepsy, ulcers, leprosy, rheumatism, and paralysis. The latex obtained from the bark is poisonous in nature and may cause temporary blindness, thus it is also known as the blind-your-eye mangrove plant. Many phytoconstituents were isolated from the plant, which were mainly diterpenoids, triterpenoids, flavonoids, sterols, and few other compounds. The plant also showed many pharmacological activities such as antioxidant, antimicrobial, anti-inflammatory, analgesic, antiulcer, anticancer, antireverse transcriptase, antihistamine-release, antifilarial, DNA damage protective, antidiabetic, and antitumor protecting activities. Hence, this review could help guide researchers anticipating to undertake further investigations in these directions.

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Agallochins J-L, New Isopimarane Diterpenoids from Excoecaria Agallocha L

Cited by 16 publications

References 8 publications

Bioactive Pimarane‐Type Diterpenes from Marine Organisms

Bioactive Pimarane‐Type Diterpenes from Marine Organisms

Polyketides From the Endophytic Fungus Cladosporium sp. Isolated From the Mangrove Plant Excoecaria agallocha

A complete profile on blind-your-eye mangrove Excoecaria agallocha L. (Euphorbiaceae): Ethnobotany, phytochemistry, and pharmacological aspects

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