Agarwood (Aquilaria malaccensis L.) a quality fragrant and medicinally significant plant based essential oil with pharmacological potentials and genotoxicity

Gogoi, Roktim; Sarma, Neelav; Begum, Twahira; Chanda, Sanjoy Kumar; Lekhak, Himangshu; Sastry, G. Narahari; Lal, Mohan

doi:10.1016/j.indcrop.2023.116535

Cited by 37 publications

(18 citation statements)

References 29 publications

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“…This may be due to differences in the extraction methods used for VOCs, cultivation environments, and tree ages of wood samples. Agarospirol has been identified in agarwood oil in many reports ( Nakanishi et al., 1984 ; Pornpunyapat et al., 2011 ; Gogoi et al., 2023 ). In the present investigation, agarospirol was the major compound of VOCs and EOs from P. zhennan wood, similar to the findings in the above report.…”

Section: Discussionmentioning

confidence: 99%

Identification and variation analysis of the composition and content of essential oil and fragrance compounds in Phoebe zhennan wood at different tree ages

Yang,

Zhang,

et al. 2024

Front. Plant Sci.

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Wood essential oil and wood products with special fragrances are high value-added forest products. Despite the availability of essential oil and volatile organic compounds (VOCs) from Phoebe zhennan wood, their variation and dependence on tree age have not been examined. After essential oil extraction and wood processing, the yields and compositions of essential oils and VOCs in wood from P. zhennan trees of different ages (10a, 30a, and 80a) were determined. The yield of essential oil from 30a wood was significantly greater than that from 10a and 80a wood. Liquid chromatography–mass spectrometry (LC−MS) and gas chromatography−mass spectrometry (GC−MS) revealed 672 and 41 volatile compounds, respectively, in the essential oil and wood, the majority of which exhibited large fluctuations in relative content and composition depending on tree age. Sesquiterpenoids, fatty acids and conjugates may greatly contribute to the main components of essential oil from wood. Almost all major sesquiterpenoid compounds, such as caryophyllene α-oxide, eudesmo, and cubebene, were identified in the essential oils from the 30a and 80a wood, and their relative contents were much greater than those in the 10a wood. The main components of the wood fragrance were sesquiterpenoids. The types and relative contents of sesquiterpenoids from wood increased with tree age. These results suggest that choosing wood from trees of a suitable age will significantly improve the efficiency of wood utilization.

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Section: Discussionmentioning

confidence: 99%

Identification and variation analysis of the composition and content of essential oil and fragrance compounds in Phoebe zhennan wood at different tree ages

Yang,

Zhang,

et al. 2024

Front. Plant Sci.

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“…The pharmacological potential of Agarwood has been explored, with studies demonstrating antimicrobial, anti-in ammatory, and antioxidant activities (da Silva e Silva et al, 2021) (Sarmah et al, 2022). The multifaceted nature of Agarwood's bioactivity has prompted increased attention from the pharmaceutical and cosmetic industries, to harness its medicinal and aromatic potential for various applications (Gogoi et al, 2023). Agarwood's applications extend beyond traditional uses, encompassing a broad spectrum of industries.…”

Section: Literature Reviewmentioning

confidence: 99%

Examining the Trend in Agarwood Oil Studies for the 5 Recent Years (2019-2023): A Bibliometric Analysis

YUSOFF,

NURLAILA,

Huzir

et al. 2024

Preprint

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This bibliometric article investigates the burgeoning research landscape surrounding Agarwood oil, derived from the Aquilaria tree species. The historical and cultural significance of Agarwood, coupled with its diverse applications in perfumery, traditional medicine, and religious practices, has fueled a surge in scientific interest. However, a comprehensive understanding of the current state of Agarwood oil research is lacking. This study addresses this gap through a systematic review and bibliometric analysis of scholarly databases. By employing techniques such as co-citation analysis and keyword co-occurrence, the research aims to quantify patterns, relationships, and collaborations within the literature. The methodology involves a focused exploration of a specified timeframe to capture recent developments, with the anticipation that the outcomes will include the identification of key contributors, thematic clusters, and emerging trends in Agarwood oil research. The study is poised to contribute valuable insights for researchers, policymakers, and industry stakeholders, offering a holistic perspective on the interconnectedness of Agarwood oil research and guiding future exploration in this dynamic field.

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“…Agarwood is rich in bioactive compounds, including sesquiterpenes, chromones, avonoids, benzophenones, diterpenoids, triterpenoids and lignans, which show myriad pharmacological effects 9,10,11 . A number of studies reported that these chemicals extracted from Aquilaria wood exhibit acetylcholinesterase inhibition, anti-fungal, anti-bacterial, anti-in ammatory, anti-cancer and analgesic actions 12,13,14 .…”

Section: Introductionmentioning

confidence: 99%

Chemical profiling and cytotoxicity screening of agarwood essential oil (Aquilaria sinensis) in brine shrimp nauplii and cancer cell lines

Chan,

Lakeh,

Wang

et al. 2024

Preprint

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Agarwood essential oil (AEO) has gained attention from healthcare industries due to its numerous pharmacological properties. However, a comprehensive understanding of the chemical composition and its cytotoxic property is lacking. The objective of this study was to investigate the chemical profile as well as the cytotoxic concentration range of AEO derived from Aquilaria sinensis wood. Gas chromatography-mass spectrometry (GC-MS) was employed to identify the AEO components. Results showed that sesquiterpenes and sesquiterpenoids constitute 95.85% of the AEO. Among the major compounds identified are allo-aromadendrene (13.04%), dihydro-eudesmol (8.81%), α-eudesmol (8.48%), bulnesol (7.63%), τ-cadinol (4.95%), dehydrofukinone (3.83%), valerenol (3.54%), cis-nerolidol (2.75%), agarospirol (2.72%), dehydrojinkoh-eremol (2.53%), selina-3,11-dien-9-al (2.36%), guaiol (2.12%) and caryophyllene oxide (2.0%). The presence of volatile quality marker compounds such as 10-epi-ϒ-eudesmol, aromadendrane, β-agarofuran, α-agarofuran, γ-eudesmol, agarospirol and guaiol, indicates that the extracted AEO is of premium grade. Interestingly, the AEO displayed moderate to high toxicity in brine shrimp lethality test (BLST). All studied tumor cell lines (MDA-MB-231, HepG2, B16F10) exhibited varying degrees of sensitivity to AEO, which resulted in time and dose-dependent reduction of cell proliferation. Our findings showed that AEO contains bioactive components that may be exploited in future studies for the development of anti-cancer therapeutics.

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Agarwood (Aquilaria malaccensis L.) a quality fragrant and medicinally significant plant based essential oil with pharmacological potentials and genotoxicity

Cited by 37 publications

References 29 publications

Identification and variation analysis of the composition and content of essential oil and fragrance compounds in Phoebe zhennan wood at different tree ages

Identification and variation analysis of the composition and content of essential oil and fragrance compounds in Phoebe zhennan wood at different tree ages

Examining the Trend in Agarwood Oil Studies for the 5 Recent Years (2019-2023): A Bibliometric Analysis

Chemical profiling and cytotoxicity screening of agarwood essential oil (Aquilaria sinensis) in brine shrimp nauplii and cancer cell lines

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