Agastache honey has superior antifungal activity in comparison with important commercial honeys

Anand, Sushil; Deighton, Margaret; Livanos, George; Pang, E. C. K.; Mantri, Nitin

doi:10.1038/s41598-019-54679-w

Cited by 38 publications

(31 citation statements)

References 67 publications

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“…The dermatophytes appeared substantially more susceptible to jarrah honey than has been reported for other H 2 O 2 -producing honeys, where MICs have ranged from 5–39% ( v / v ) [ 19 , 20 ]. Our results are in contrast to a recent study of a commercial jarrah honey, however, which had no activity against Trichophyton mentagrophytes and T. rubrum [ 28 ]. H 2 O 2 -producing honeys can be highly variable in activity, which can be influenced by age, processing and storage conditions as well as bee health and geographic factors, and even fresh and unprocessed samples can range from very high to negligible activity [ 21 , 29 ].…”

Section: Discussioncontrasting

confidence: 99%

Inhibition of Dermatophyte Fungi by Australian Jarrah Honey

et al. 2021

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Superficial dermatophyte infections, commonly known as tineas, are the most prevalent fungal ailment and are increasing in incidence, leading to an interest in alternative treatments. Many floral honeys possess antimicrobial activity due to high sugar, low pH, and the production of hydrogen peroxide (H2O2) from the activity of the bee-derived enzyme glucose oxidase. Australian jarrah (Eucalyptus marginata) honey produces particularly high levels of H2O2 and has been found to be potently antifungal. This study characterized the activity of jarrah honey on fungal dermatophyte species. Jarrah honey inhibited dermatophytes with minimum inhibitory concentrations (MICs) of 1.5–3.5% (w/v), which increased to ≥ 25% (w/v) when catalase was added. Microscopic analysis found jarrah honey inhibited the germination of Trichophyton rubrum conidia and scanning electron microscopy of mature T. rubrum hyphae after honey treatment revealed bulging and collapsed regions. When treated hyphae were stained using REDOX fluorophores these did not detect any internal oxidative stress, suggesting jarrah honey acts largely on the hyphal surface. Although H2O2 appears critical for the antifungal activity of jarrah honey and its action on fungal cells, these effects persisted when H2O2 was eliminated and could not be replicated using synthetic honey spiked with H2O2, indicating jarrah honey contains agents that augment antifungal activity.

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Section: Discussioncontrasting

confidence: 99%

Inhibition of Dermatophyte Fungi by Australian Jarrah Honey

et al. 2021

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“…Increasing the concentration of honey from 16% to 40% led to a 2-log reduction in the CFU of C. auris , while the CFUs of the other Candida species were also reduced by 1- to 4-log, with C. glabrata being least susceptible and C. krusei most susceptible. As previous studies found differences in the susceptibility of yeasts to different types of honey [ 11 , 12 , 13 ], the five Candida species were also treated with a local unprocessed honey. Local unprocessed honey (40%) caused a 2- to 5-log reduction in all Candida species.…”

Section: Discussionmentioning

confidence: 99%

“…A promising candidate for the treatment of yeasts in wounds and skin colonization is honey. Medical-grade honey follows strict criteria to guarantee its safety, quality, and efficacy, and was also found to be effective in inhibiting different Candida species, such as C. albicans and C. tropicalis [ 10 , 11 , 12 , 13 ]. Medical-grade honey consists of more than 200 different components influenced by its botanical origin, geographical location and secretions from the bee [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Antifungal Activity of a Medical-Grade Honey Formulation against Candida auris

Groot

Janssen

Faro

et al. 2021

JoF

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Candida auris is a pathogenic yeast causing outbreaks in intensive care units with high mortality rates. The treatment of C. auris colonization is challenging due to high resistance rates. A potential alternative antifungal treatment is medical-grade honey. In this study the susceptibility of C. auris and other Candida species to the medical-grade honey-based formulation L-Mesitran® Soft was investigated. The medical-grade honey formulation reduced the growth of C. auris and other Candida species in a dose-dependent manner. This inhibition was not only due to the honey component, as treatment with an identical concentration of this component only was less effective and even stimulated the growth of C. albicans and C. glabrata, supporting the interpretation that supplements in the medical-grade honey formulation enhanced the antimicrobial activity. Increasing the concentration of the honey component to 40%, as is also present in an undiluted medical-grade honey formulation, lead to a 1- to 4-log inhibition of all Candida species. Unprocessed local honey reduced the growth of nearly all Candida species more strongly than medical-grade honey. C. auris’ susceptibility to the medical-grade honey formulation did not depend on geographic origin or resistance profile, although the multiresistant isolates tended to be more susceptible. Altogether, medical-grade honey formulation has a strong antifungal activity against C. auris and other Candida species. Future studies should demonstrate whether the treatment of open wounds or skin colonized with C. auris is feasible and effective in the clinical setting.

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“…Honey is definitely the most studied bee product regarding its antimicrobial properties. It is reported to exert antibacterial [ 4 , 5 , 6 , 7 ], antifungal [ 8 ], and antiviral activity [ 9 , 10 , 11 ]. In addition, it exhibits anti-inflammatory and wound-healing action [ 12 ], as well as anticancer properties [ 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Biological Properties of Bee Bread Collected from Apiaries Located across Greece

et al. 2021

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Bee bread is the only fermented product of the beehive. It constitutes the main source of proteins, lipids, vitamins, and macro- and microelements in honeybee nutrition and it exerts antioxidant and antimicrobial properties, though research on these aspects has been limited so far. In this study 18 samples of Greek bee bread, two of which were monofloral, were collected during different seasons from diverse locations such as Crete and Mount Athos and were tested for their bioactivity. Samples were analyzed for their antibacterial properties, antioxidant activity, total phenolic content (TPC), and total flavonoid content (TFC). The antimicrobial activity of each sample was tested against Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Salmonella typhimurium. Our data demonstrate that all samples exert inhibitory and most of them bactericidal activity against at least two pathogens. Furthermore, all samples exert significant antioxidant activity, where the monofloral Castanea Sativa sample demonstrated superior antioxidant activity. Nevertheless, the antioxidant and antimicrobial activity were not strongly correlated. Furthermore, machine learning methods demonstrated that the palynological composition of the samples is a good predictor of their TPC and ABTS activity. This is the first study that focuses on the biological properties of Greek bee bread and demonstrates that bee bread can be considered a functional food and a possible source of novel antimicrobial compounds.

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Agastache honey has superior antifungal activity in comparison with important commercial honeys

Cited by 38 publications

References 67 publications

Inhibition of Dermatophyte Fungi by Australian Jarrah Honey

Inhibition of Dermatophyte Fungi by Australian Jarrah Honey

Antifungal Activity of a Medical-Grade Honey Formulation against Candida auris

Biological Properties of Bee Bread Collected from Apiaries Located across Greece

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