Age Affects Photoentrainment in a Nocturnal Primate

Gomez, Doris; Barbosa, Alexandra; Théry, Marc; Aujard, Fabienne; Perret, Martine

doi:10.1177/0748730411435223

Cited by 12 publications

(9 citation statements)

References 33 publications

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“…This general loss of responsiveness to light has also been shown in aging mouse lemurs (Gomez et al 2012). Though in our study defined minor lens opacities (like e.g.…”

Section: Nuclear Sclerosis Onset and Its Dependency On The Photoperiodsupporting

confidence: 80%

Photoperiodic regime influences onset of lens opacities in a non-human primate

Dubicanac

Strueve

Mestre‐Francés

et al. 2017

Preprint

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Background. Opacities of the lens are typical age related phenomena which have high influence on photoreception and consequently circadian rhythm. In mouse lemurs, a small bodied non-human primate, a high incidence (more than 50% when > 7 years) of cataract has been previously described during aging. Previous studies showed that photoperiodical induced accelerated annual rhythms alter some of mouse lemurs' life history traits.Whether a modification of photoperiod also affects the onset of age dependent lens opacities has not been investigated so far. The aim of this study was therefore to characterize the type of opacity and the mouse lemurs' age at its onset in two colonies with different photoperiodic regimen. Methods. Two of the largest mouse lemur colonies in Europe have been investigated; Colony 1 with a natural annual photoperiodic regime and Colony 2 with an induced accelerated annual cycle. A Slit-lamp was used to determine opacities in the lens and a subset of all animals which showed no opacities in the lens nucleus in the first examination but developed first changes in the following examination were further used to estimate the age at onset of opacities. In total 387 animals were examined and 57 represent the subset for age at onset estimation. Results. The first and most common observable opacity in the lens was nuclear sclerosis. Mouse lemurs from Colony 1 showed a delayed onset of nuclear sclerosis compared to mouse lemurs of Colony 2 (4.35 ± 1.50 years vs. 2.75 ± 0.99 years). For colony 1, the chronological age was equivalent to the number of seasonal cycles experienced by the mouse lemurs. For colony 2, in which seasonal cycles are accelerated by factor 1.5, mouse lemurs had experienced 4.13 ± 1.50 seasonal cycles in 2.75 ± 0.99 chronological years. Discussion.Our study showed clear differences in the age at the onset of nuclear sclerosis formation can be used as an estimation for risk of beginning NS formation. Ophthalmological investigations should be taken into account when animals older than 5 -6 seasonal cycles are used for experiments in which unrestricted visual ability has to be ensured. This study is the first to assess and demonstrate the influence of annual photoperiod regime on the incidence of lens opacities in a non-human primate.PeerJ Preprints | https://doi.org/10.7287/peerj.preprints.2714v1 | CC BY 4.0 Open Access | rec: 11 Jan 2017, publ: 11 Jan 2017Photoperiodic regime influences onset of lens opacities in a non-human primate

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“…This general loss of responsiveness to light has also been shown in aging mouse lemurs (Gomez et al 2012). Though in our study defined minor lens opacities (like e.g.…”

Section: Nuclear Sclerosis Onset and Its Dependency On The Photoperiodsupporting

confidence: 80%

Photoperiodic regime influences onset of lens opacities in a non-human primate

Dubicanac

Strueve

Mestre‐Francés

et al. 2017

Preprint

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“…The loss of circadian photoreception highly affects the physiological and mental state and a diversity of cardiovascular, respiratory, endocrine, rheumatological and neurological diseases has been linked to variations in circadian rhythms (Klerman, 2005). A general loss of responsiveness to light has also been shown in aging mouse lemurs (Gomez et al, 2012). The relevant causes are still not clear but possible reasons could be similar to those in humans like the dysfunction of neural transmission or increased shortwave absorption of the lens (Jackson & Owsley, 2000; Revell & Skene, 2010).…”

Section: Discussionmentioning

confidence: 87%

“…Nowadays the grey mouse lemur ( Microcebus murinus ) is suggested to represent a promising non-human primate model in aging (Perret, 1997; Cayetanot et al, 2005; Gomez et al, 2012; Languille et al, 2012; Zimmermann & Radespiel, 2014; Zimmermann et al, 2016) and Alzheimer’s research (Austad & Fischer, 2011; Verdier et al, 2015). With a life expectancy of about eight years in the wild (Zimmermann et al, 2016) and up to 18.5 years (Weigl & Jones, 2005) in captivity, mouse lemurs live much shorter than other non-human primates.…”

Section: Introductionmentioning

confidence: 99%

Photoperiodic regime influences onset of lens opacities in a non-human primate

Dubicanac

Strueve

Mestre‐Francés

et al. 2017

PeerJ

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Background. Opacities of the lens are typical age-related phenomena which have a high influence on photoreception and consequently circadian rhythm. In mouse lemurs, a small bodied non-human primate, a high incidence (more than 50% when >seven years) of cataracts has been previously described during aging. Previous studies showed that photoperiodically induced accelerated annual rhythms alter some of mouse lemurs' life history traits. Whether a modification of photoperiod also affects the onset of age dependent lens opacities has not been investigated so far. The aim of this study was therefore to characterise the type of opacity and the mouse lemurs' age at its onset in two colonies with different photoperiodic regimen. Methods. Two of the largest mouse lemur colonies in Europe were investigated: Colony 1 having a natural annual photoperiodic regime and Colony 2 with an induced accelerated annual cycle. A slit-lamp was used to determine opacities in the lens. Furthermore, a subset of all animals which showed no opacities in the lens nucleus in the first examination but developed first changes in the following examination were further examined to estimate the age at onset of opacities. In total, 387 animals were examined and 57 represented the subset for age at onset estimation. Results . The first and most commonly observable opacity in the lens was nuclear sclerosis. Mouse lemurs from Colony 1 showed a delayed onset of nuclear sclerosis compared to mouse lemurs from Colony 2 (4.35 ± 1.50 years vs. 2.75 ± 0.99 years). For colony 1, the chronological age was equivalent to the number of seasonal cycles experienced by the mouse lemurs. For colony 2, in which seasonal cycles were accelerated by a factor of 1.5, mouse lemurs had experienced 4.13 ± 1.50 seasonal cycles in 2.75 ± 0.99 chronological years. Discussion. Our study showed clear differences in age at the onset of nuclear sclerosis formation between lemurs kept under different photoperiodic regimes. Instead of measuring the chronological age, the number of seasonal cycles (N = four) experienced by a mouse lemur can be used to estimate the risk of beginning nuclear sclerosis formation. Ophthalmological examinations should be taken into account when animals older than 5-6 seasonal cycles are used for experiments in which unrestricted visual ability has to be ensured. This study is the first to assess and demonstrate the influence of annual photoperiod regime on the incidence of lens opacities in a non-human primate.

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“…It has been observed a high incidence of ocular pathologies in more than 7 years old mouse lemurs, what suggests a decrease in light responsiveness through the filtering of short wavelengths (Beltran et al, 2007). It has been demonstrated that short wavelengths are efficient in the synchronization of daily rhythms in mouse lemurs (Gomez et al, 2012). In addition, the impact of aging on circadian rhythms in mouse lemur has been associated with immune system alterations.…”

Section: Potential Markers Of Behavioral and Psychological Symptoms Omentioning

confidence: 99%

Strengths and Weaknesses of the Gray Mouse Lemur (Microcebus murinus) as a Model for the Behavioral and Psychological Symptoms and Neuropsychiatric Symptoms of Dementia

2019

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To face the load of the prevalence of Alzheimer’s disease in the aging population, there is an urgent need to develop more translatable animal models with similarities to humans in both the symptomatology and physiopathology of dementia. Due to their close evolutionary similarity to humans, non-human primates (NHPs) are of primary interest. Of the NHPs, to date, the gray mouse lemur (Microcebus murinus) has shown promising evidence of its translatability to humans. The present review reports the known advantages and limitations of using this species at all levels of investigation in the context of neuropsychiatric conditions. In this easily bred Malagasy primate with a relatively short life span (approximately 12 years), age-related cognitive decline, amyloid angiopathy, and risk factors (i.e., glucoregulatory imbalance) are congruent with those observed in humans. More specifically, analogous behavioral and psychological symptoms and neuropsychiatric symptoms of dementia (BPSD/NPS) to those in humans can be found in the aging mouse lemur. Aged mouse lemurs show typical age-related alterations of locomotor activity daily rhythms such as decreased rhythm amplitude, increased fragmentation, and increased activity during the resting-sleeping phase of the day and desynchronization with the light-dark cycle. In addition, sleep deprivation successfully induces cognitive deficits in adult mouse lemurs, and the effectiveness of approved cognitive enhancers such as acetylcholinesterase inhibitors or N-methyl-D-aspartate antagonists is demonstrated in sleep–deprived animals. This result supports the translational potential of this animal model, especially for unraveling the mechanisms underlying dementia and for developing novel therapeutics to prevent age-associated cognitive decline. In conclusion, actual knowledge of BPSD/NPS-like symptoms of age-related cognitive deficits in the gray mouse lemur and the recent demonstration of the similarity of these symptoms with those seen in humans offer promising new ways of investigating both the prevention and treatment of pathological aging.

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Age Affects Photoentrainment in a Nocturnal Primate

Cited by 12 publications

References 33 publications

Photoperiodic regime influences onset of lens opacities in a non-human primate

Photoperiodic regime influences onset of lens opacities in a non-human primate

Photoperiodic regime influences onset of lens opacities in a non-human primate

Strengths and Weaknesses of the Gray Mouse Lemur (Microcebus murinus) as a Model for the Behavioral and Psychological Symptoms and Neuropsychiatric Symptoms of Dementia

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