Age, alcohol metabolism and liver disease

Meier, Patrick; Seitz, Helmut K.

doi:10.1097/mco.0b013e3282f30564

Cited by 175 publications

(134 citation statements)

References 34 publications

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“…Having qualifications may therefore be particularly associated with economic resources in older age groups, and this in turn correlates with happiness (Bowling et al, 2007). Older people are also less likely to abuse alcohol, possibly because heavy drinkers die young, and they are more vulnerable to its negative effects (Meier and Seitz, 2008).…”

Section: Introductionmentioning

confidence: 99%

Happiness across age groups: results from the 2007 National Psychiatric Morbidity Survey

Cooper¹,

Bebbington²,

King³

et al. 2010

Int. J. Geriat. Psychiatry

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Section: Introductionmentioning

confidence: 99%

Happiness across age groups: results from the 2007 National Psychiatric Morbidity Survey

Cooper¹,

Bebbington²,

King³

et al. 2010

Int. J. Geriat. Psychiatry

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“…Aldehyde dehydrogenases (ALDHs) then oxidize acetaldehyde to acetate and water (Crabb et al, 2004). Acetaldehyde, the intermediate metabolite of ethanol, is toxic and its accumulation contributes significantly to ethanol-induced tissue damage (Eriksson, 2001;Meier and Seitz, 2008). The toxicity of acetaldehyde is caused by it covalently binding biological macromolecules, such as proteins and nucleic acids and forming adducts that impair their functions (Niemelä, 2007).…”

Section: Introductionmentioning

confidence: 99%

Aldehyde Dehydrogenase 1B1: Molecular Cloning and Characterization of a Novel Mitochondrial Acetaldehyde-Metabolizing Enzyme

Stagos¹,

Chen²,

Brocker³

et al. 2010

Drug Metab Dispos

121

114

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ABSTRACT:Ethanol-induced damage is largely attributed to its toxic metabolite, acetaldehyde. Clearance of acetaldehyde is achieved by its oxidation, primarily catalyzed by the mitochondrial class II aldehyde dehydrogenase (ALDH2). ALDH1B1 is another mitochondrial aldehyde dehydrogenase (ALDH) that shares 75% peptide sequence homology with ALDH2. Recent population studies in whites suggest a role for ALDH1B1 in ethanol metabolism. However, to date, no formal documentation of the biochemical properties of ALDH1B1 has been forthcoming. In this current study, we cloned and expressed human recombinant ALDH1B1 in Sf9 insect cells. The resultant enzyme was purified by affinity chromatography to homogeneity. The kinetic properties of purified human ALDH1B1 were assessed using a wide range of aldehyde substrates. Human ALDH1B1 had an exclusive preference for NAD ؉ as the cofactor and was catalytically active toward short-and medium-chain aliphatic aldehydes, aromatic aldehydes, and the products of lipid peroxidation, 4-hydroxynonenal and malondialdehyde. Most importantly, human ALDH1B1 exhibited an apparent K m of 55 M for acetaldehyde, making it the second low K m ALDH for metabolism of this substrate. The dehydrogenase activity of ALDH1B1 was sensitive to disulfiram inhibition, a feature also shared with ALDH2. The tissue distribution of ALDH1B1 in C57BL/6J mice and humans was examined by quantitative polymerase chain reaction, Western blotting, and immunohistochemical analysis. The highest expression occurred in the liver, followed by the intestinal tract, implying a potential physiological role for ALDH1B1 in these tissues. The current study is the first report on the expression, purification, and biochemical characterization of human ALDH1B1 protein.

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“…Specifically, regarding sedative-hypnotic drugs use, older persons may be more susceptible to addictive central nervous system effects than younger persons because of physiologic changes in psychotropic drug and alcohol metabolism [42] so it should be important to consider patients' alcohol consumption patterns before prescribing potential interfering drugs. High alcohol consumption is linked to liver disease [43] and produces detrimental effects on executive function (for example, the ability to form concepts, organize thoughts and activities, prioritize tasks, and think abstractly).…”

Section: Stop Smoking and Reduce Alcohol Usementioning

confidence: 99%