Age, alcohol, sex, and metabolic factors as risk factors for colonic diverticulosis

Yan, Yizhong; Wu, Jiansheng; Pan, Shuang

doi:10.12998/wjcc.v10.i1.136

Cited by 8 publications

(10 citation statements)

References 30 publications

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“…Recent literature has focused on exploring the association between MetS and CD. Yan et al discovered risk factors, such as age over 60 years, obesity, hypertension, and hypertriglyceridemia, were associated with an increased risk of CD [25]. Teixeira et al found bidirectional links between CD and MetS, with central obesity, hypertension, and insulin resistance correlating individually with CD risk [26].…”

Section: Discussionmentioning

confidence: 99%

Association of Metabolic Syndrome Components and Colonic Diverticulosis in the Very Elderly: A Tertiary Health Network Study

Liaquat,

Harmouch,

Patel

et al. 2024

Cureus

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IntroductionThere is scarce data about the association of metabolic syndrome (MetS) or its components with the development of colonic diverticulosis (CD) in the elderly. We aim to determine the association of MetS and its components with CD in the elderly aged ≥75 years. MethodsWe conducted a retrospective chart review at St. Luke's University Health Network to identify patients who underwent a colonoscopy between 2011 and 2020. We collected data on patient demographics, comorbidities, and colonoscopy findings. Statistical analyses were conducted to compute means and frequencies of patient characteristics and rates of CD, as well as to test for associations between potential risk factors and the presence of CD. ResultsA total of 1239 patients were included with a median age of 80 years, 57.6% females, 89.5% Caucasians, 72.9% with CD, and 66.7% having a left-sided disease. On bivariate analysis, the older age group (p=0.02), Caucasian ethnicity (p=0.01), and hypertension (p=0.04) were found to be significant risk factors for developing CD. Multivariate regression analysis showed older age group and hypertension (OR=1.47, 95% CI: 1.66-2.02, p=0.02) were major risk factors. A significant proportion of patients with left-sided disease had Caucasian ethnicity (p<0.001), while female gender, obesity, and iron deficiency anemia were also seen more frequently, although without statistical significance. ConclusionIn the elderly (>75 years old), our study found hypertension to be associated with an increased risk of CD, while impaired fasting glucose (IFG) was protective. Most patients exhibited isolated left-sided diverticulosis, with pan-diverticulosis associated with higher proportions of adverse health indicators, including American Society of Anesthesiologists (ASA) score ≥3, IFG, hypertriglyceridemia, hypertension, and hypothyroidism. Further research with larger sample sizes in similar age groups is needed to expand upon these findings.

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Section: Discussionmentioning

confidence: 99%

Association of Metabolic Syndrome Components and Colonic Diverticulosis in the Very Elderly: A Tertiary Health Network Study

Liaquat,

Harmouch,

Patel

et al. 2024

Cureus

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“…Left colonic diverticular is more prevalent in the West, while Asians have a predominance of diverticula in the right colon [52,66]. Studies conducted in Asia found a right-sided diverticulosis distribution in up to 88.4% of the cases [60,67]. Right colonic diverticulosis has a multifactorial etiology including genetic predisposition and structural colonic wall changes with mixed process of congenital outpouching of the full thickness of colonic wall and an acquired partial wall thickness [67].…”

Section: Discussionmentioning

confidence: 99%

Colonic Diverticulosis at Colonoscopy in Africa: A Systematic Review and Meta-Analysis of Pooled Estimates

Ray-Offor,

Egboh,

Ijah

et al. 2024

Dig Surg

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Background: There is need to ascertain any epidemiologic shift of diverticulosis among Africans with traditionally high fiber diet consumption patterns and rare diverticulosis prevalence. Methods: We systematically searched PubMed, Scopus, Cochrane Library, African Journal Online (AJOL) and Google Scholar. Eligibility criteria included full text observational and experimental human colonoscopy studies on asymptomatic and symptomatic African population from 1985-2022. Case reports, conference abstracts, dissertations, systematic reviews, and studies lacking colonoscopy findings were excluded. NIH quality assessment tool for observational cohort and cross-sectional studies was used to assess risk of bias. Meta-analysis was performed using the random-effect model. Heterogeneity was assessed using inconsistency (I2) statistics. Results: Thirty studies were included. Pooled prevalence rate of colonic diverticulosis was 9.1% (95%CI 7.1-11.2; I2=96.3%) with highest regional prevalence rate in West African studies at 11.3% (95%CI 7.6-14.9; I2=96.2%). Proportion of individuals with diverticulosis ≥50 years and male sex were 86.9 % (95%CI 80.5-92.1) and 65.2% (95%CI 55.0-74.8), respectively. Left colon had the highest diverticulosis frequency [37% (148/400)]. Bleeding/inflammation complications were sparingly detected [OR 0.2 (95%CI 0.03-0.75;p<0.0001)]. Conclusion: Colonic diverticulosis was most common in males aged >50. Left was colon predominantly affected. Regional variation in detection of diverticulosis was reported across Africa.

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“…Reduced rectosigmoid motility caused by alcohol consumption may be an important pathogenic factor of diverticula formation. Alcohol inhibits colonic motility through activation of the nuclear factor-κB pathway and the subsequent upregulation of inducible nitric oxide synthase expression, thus resulting in increased intracolonic pressure and colonic diverticulosis [ 33 ]. Some studies have also analyzed the influence of alcohol overuse on the probability of diverticular complications such as diverticular bleeding.…”

Section: Discussionmentioning

confidence: 99%

Concomitant diverticulosis among patients undergoing liver transplantation. Does it influence the length of hospitalization after the procedure?

Menżyk,

Skladany,

Adamcova-Selcanova

et al. 2023

ceh

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Aim of the study We tried to assess the influence of concomitant diverticulosis and other factors, e.g., Child-Pugh (C-P) and MELD scores, viral etiology, and presence of alcoholic disease, on short-term results of liver transplantation (LT) with an emphasis on duration of patient’s hospitalization. Material and methods This prospective study was performed on 206 cirrhotic patients who were selected for LT. In order to assess the presence of diverticculosis we performed colonoscopy. Results The duration of hospitalization after LT did not differ significantly between patients with and without diverticulosis (27.5 [21.0-33.5] vs. 24.0 [18.0-32.0] days, p = 0.28). Patients with C-P class C were hospitalized longer in comparison to the class B patients. It is reflected in the positive correlation between C-P score and days of hospitalization ( r = 0.22, p = 0.002). Patients with diverticulosis were significantly older (59.6 [51.1-63.3] vs. 52.9 [43.8-59.2] years, p = 0.03). Alcoholic liver disease (ALD) was associated with a greater risk of diverticulosis (OR = 3.89, 95% CI [1.13-15.87], p = 0.04). Conclusions Presence of diverticulosis among subjects undergoing LT did not influence the duration of hospitalization after the procedure. Significantly longer hospitalization was observed in patients with the most advanced liver disease according to C-P score. To determine the exact impact of diverticulosis on short-term results of LT additional studies are required.

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Age, alcohol, sex, and metabolic factors as risk factors for colonic diverticulosis

Cited by 8 publications

References 30 publications

Association of Metabolic Syndrome Components and Colonic Diverticulosis in the Very Elderly: A Tertiary Health Network Study

Association of Metabolic Syndrome Components and Colonic Diverticulosis in the Very Elderly: A Tertiary Health Network Study

Colonic Diverticulosis at Colonoscopy in Africa: A Systematic Review and Meta-Analysis of Pooled Estimates

Concomitant diverticulosis among patients undergoing liver transplantation. Does it influence the length of hospitalization after the procedure?

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