Age and Bladder Outlet Obstruction Are Independently Associated with Detrusor Overactivity in Patients with Benign Prostatic Hyperplasia

Oelke, Matthias; Baard, Joyce; Wijkstra, Hessel; Rosette, Jean J. de la; Jonas, Udo; Höfner, K.

doi:10.1016/j.eururo.2008.02.017

Cited by 175 publications

(117 citation statements)

References 28 publications

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“…This finding was in accordance with our previous study which revealed a positive correlation between the presence of IDO and BOOI. 8 There was an increasing probability of IDO with increasing BOOI as shown in linear-by-linear association test (P50.041), confirmed by a recent report by Oelke et al 9 They demonstrated that with increasing BOO grade, there was an increasing probability of detusor overactivity and tendency toward an earlier appearance and higher amplitude of detusor overactivity.…”

Section: Discussionsupporting

confidence: 68%

Is there a correlation between the outcome of transurethral resection of prostate and preoperative degree of bladder outlet obstruction?

Oh¹,

Kim²,

Kim³

et al. 2011

Asian J Androl

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To compare the impact of transurethral resection of prostate (TURP) on symptom scores and maximal flow rates (Qmax) in patients with equivocal bladder outlet obstruction (BOO) and definite BOO and to assess the relationship between the surgical outcomes and degree of preoperative BOO, we prospectively evaluated men with lower urinary tract symptoms and bladder outlet obstruction index (BOOI) greater than 20, who were refractory to conventional medical treatment and underwent TURP. Urodynamic evaluation, International Prostate Symptom Score (IPSS), uroflowmetry, post-void residual volume (PVR) check and transrectal ultrasound were performed. 20,BOOI,40 was defined as equivocal BOO and BOOIo40 as definite BOO. Changes of IPSS, Qmax, PVR and correlation analysis was performed between the degree of improvement of Qmax, subdomains of IPSS and BOOI. Fifty-four patients showed equivocal BOO and 80 patients showed definite BOO. Preoperatively equivocal BOO group and definite BOO group showed significant differences in maximal bladder capacity and prevalence of detrusor overactivity, whereas no difference was noted in prostate volume. Postoperatively both groups showed improvements in Qmax, obstructive (IPSSO) and irritative (IPSSI) subdomain of IPSS, but the degree of improvement in Qmax and IPSSI subdomain was statistically significantly greater in definite BOO group. The degree of improvement of Qmax and IPSSI showed weak correlation with preoperative BOOI. As a weak correlation was identified between preoperative degree of BOO and outcome of TURP, other factors other than BOOI such as severity of patients' symptoms should be considered in deciding treatment modality.

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Section: Discussionsupporting

confidence: 68%

Is there a correlation between the outcome of transurethral resection of prostate and preoperative degree of bladder outlet obstruction?

Oh¹,

Kim²,

Kim³

et al. 2011

Asian J Androl

View full text Add to dashboard Cite

show abstract

“…In addition, no correlation was found between amplitude of involuntary detrusor contractions and subjective report of urgency in patients with OAB symptoms (Romanzi et al, 2001). DO is a common (50-75%) urodynamic occurrence in patients with bladder outflow obstruction due to benign prostatic hyperplasia (Robertson, 1999;Nordling, 2002;Oelke et al, 2008). It is still not completely understood which particular changes in contractile activity of the bladder during urine storage phase could be responsible for OAB symptoms in patients with bladder outflow obstruction.…”

Section: Introductionmentioning

confidence: 92%

“…non-voiding involuntary detrusor contractions during urine storage phase) is usually responsible for OAB with urge incontinence. In males, bladder outlet obstruction is the most likely cause of DO (Nordling, 2002;Mirone et al, 2007;Oelke et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Conscious voiding during bladder obstruction in guinea pigs correlates with contractile activity of isolated bladders

Nicholas

Keightley

Brookes

et al. 2015

Autonomic Neuroscience

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Purpose: There are many hypotheses accounting for detrusor overactivity, however the exact mechanisms are still incompletely understood. We used a model of bladder outlet obstruction in male guinea pigs as a way to produce detrusor overactivity. The objective was to determine whether changes in voiding of obstructed guinea pigs correlates with specific changes in contractile activity of their isolated bladders in vitro. Material and methods: Conscious voiding activity of sham-operated and obstructed animals was measured in metabolic cages. Contractile activity (spontaneous or evoked by distension, electrical field stimulation or cholinergic agonists) was recorded via a pressure transducer in the isolated bladders in vitro. Results: The frequency of conscious voiding increased (while voiding volume decreased) in the obstructed group, compared with the sham-operated group, 4 weeks after surgical intervention. In comparison to the sham-operated animals, the bladders from the obstructed guinea pigs were enlarged and inflamed, their frequency of spontaneous contractions was higher, while the amplitudes of electrical field stimulation (EFS)-induced contractions and bladder compliance were lower. Changes in conscious voiding during obstruction were significantly associated with alterations in structural parameters (bladder weight, thickness and histological damage score) and functional contractile parameters (frequency of spontaneous contractions, amplitude of EFS-induced contractions and bladder compliance) of their isolated bladders. Conclusions: Our findings revealed significant association between conscious voiding and structural and contractile activity changes of the isolated bladders in obstruction. The data suggest that change in contractile activity of the bladder itself is a major contributor to obstruction-induced bladder overactivity.

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“…Risikofaktoren für eine Detrusorüberaktivität sind neben steigendem Alter, Miktionsbeschwerden und zunehmende Prostatagrösse [16]. Nach transurethraler Resektion der Prostata (TUR-P) kann die Überaktivität in 25% der Fälle persistieren [17].…”

Section: Ursachenunclassified

Urininkontinenz beim Mann – ein Tabuthema

Kozomara-Hocke

Hermanns

Poyet

2016

Praxis

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Male urinary incontinence is an underestimated and frequently not broached issue. The urinary incontinence is divided into stress-, urge incontinence and hybrid forms as well as overflow incontinence. The fact that there are increasingly more men over 60 means that the prevalence of the urinary incontinence is up to 40%, and urinary incontinence will increasingly gain importance in daily routine practice. Many investigations and therapies can be realized by the general practitioner. Already simple therapy approaches can lead to a considerable clinical improvement of male urinary incontinence. If the initial therapy fails or pathological results (i. e. microhaematuria, recurrent urinary tract infections, raised residual urine and so on) are found, the patient should be referred to a urologist. Si la thérapie primaire ne réussit pas à résoudre l'incontinence urinaire ou on trouve des résultats pathologique (hématurie microscopique, infection urinaire récidivé, urine résiduelle augmenté etc.) le patient doit être envoyé chez le spécialiste d'urologie.4

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Age and Bladder Outlet Obstruction Are Independently Associated with Detrusor Overactivity in Patients with Benign Prostatic Hyperplasia

Cited by 175 publications

References 28 publications

Is there a correlation between the outcome of transurethral resection of prostate and preoperative degree of bladder outlet obstruction?

Is there a correlation between the outcome of transurethral resection of prostate and preoperative degree of bladder outlet obstruction?

Conscious voiding during bladder obstruction in guinea pigs correlates with contractile activity of isolated bladders

Urininkontinenz beim Mann – ein Tabuthema

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