Age and experience-related improvements in gap detection in the rat

Friedman, Jennifer T.; Peiffer, Ann M.; Clark, Matthew G.; Benasich, April A.; Fitch, R. Holly

doi:10.1016/j.devbrainres.2004.06.007

Cited by 53 publications

(71 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The auditory deficits have been shown in affected males using a variety of approaches, which include operant conditioning paradigms, oddball paradigms using startle responses, and auditory evoked potentials (Friedman et al, 2004;McClure, Peiffer, Rosen, & Fitch, 2005;Peiffer et al, 2001;Peiffer, Friedman, Rosen, & Fitch, 2004a;Peiffer, McClure, Threlkeld, Rosen, & Fitch, 2004b;Peiffer, Rosen, & Fitch, 2002a, 2002b, 2004c. It remains to be shown whether cortical malformations in the dyslexic brain, which are associated with thalamic changes in the same brains, lead to auditory processing problems, some of which resolve with maturation, and whether these auditory processing problems are fundamentally related causally to the phonological deficits typical of phonological dyslexia.…”

Section: Neuronal Migration Anomalies and Behavior: Animal Studiesmentioning

confidence: 94%

Dyslexia—A molecular disorder of neuronal migration

Galaburda

2005

Ann. of Dyslexia

View full text Add to dashboard Cite

For 25 years now, there has been a serious attempt to get at the fundamental cause(s) of dyslexia in our laboratory. A great deal of research has been carried out on the psychological and brain underpinnings of the linguistic dysfunctions seen in dyslexia, but attempts to get at its cause have been limited. Initially, observations were made on the brains of persons with dyslexia who had died and their brains donated for research. These observations were modeled in animal models in order to better understand the full extent of anatomical and developmental brain characteristics. More recently, models have begun to employ genetic manipulations in order to close the gap between genes, brain, and behavior. In this article based on a lecture given in memory of Dr. Norman Geschwind to the International Dyslexia Association assembly in Philadelphia in 2004, I outline the history of the research leading up to the most recent findings. These findings consist of experiments using methods that interfere with the function of DNA, using as constructs genes that have been implicated in dyslexia, which cause developmental problems of neuronal migration in rats, secondary brain changes in response to the migration problems, and abnormal processing of sounds.

show abstract

Section: Neuronal Migration Anomalies and Behavior: Animal Studiesmentioning

confidence: 94%

Dyslexia—A molecular disorder of neuronal migration

Galaburda

2005

Ann. of Dyslexia

View full text Add to dashboard Cite

show abstract

“…For example, clinical behavioral profiles frequently reflect pathology in multiple processing and learning domains that vary depending upon the stage of development (Conklin, et al, 2008, Hagberg, et al, 2002, Luu, et al, 2011, McClure, et al, 2006, Ortiz-Mantilla, et al, 2008, Woodward, et al, 2005). In addition, neurobehavioral outcomes after brain injury in humans and animal models can vary depending on injury progression, timing of behavioral assessment after initial injury, and the behavioral domains examined ( e.g ., motor, working memory, spatial learning, non-spatial learning and/or sensory processing (Back, et al, 2002, Ferriero, 2004, Fitch, et al, 2013, Friedman, et al, 2004, Threlkeld, et al, 2009, Threlkeld, et al, 2006)). In order to understand the extent of possible neuroprotection afforded by IAIPs, comprehensive assessments across multiple learning domains, brain regions and ages post-insult are essential for understanding the short and long-term effects of these molecules following developmental brain injury (Fitch, et al, 2013, Friedman, et al, 2004, Threlkeld, et al, 2009, Threlkeld, et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Effects of inter-alpha inhibitor proteins on neonatal brain injury: Age, task and treatment dependent neurobehavioral outcomes

Threlkeld

Gaudet

Rue

et al. 2014

Experimental Neurology

View full text Add to dashboard Cite

Hypoxic-ischemic (HI) brain injury is frequently associated with premature and/or full term birth related complications. HI injury often results in learning and processing deficits that reflect widespread damage to an extensive range of cortical and sub-cortical brain structures. Further, inflammation has been implicated in the long-term progression and severity of HI injury. Recently, Inter-alpha Inhibitor Proteins (IAIPs) have been shown to attenuate inflammation in models of systemic infection. Importantly, preclinical studies of neonatal HI injury and neuroprotection often focus on single time windows of assessment or single behavioral domains. This approach limits translational validity, given evidence for a diverse spectrum of neurobehavioral deficits that may change across developmental windows following neonatal brain injury. Therefore, the aims of this research were to assess the effects of human IAIPs on early neocortical cell death (72 hours post insult), adult regional brain volume measurements (cerebral cortex, hippocampus, striatum, corpus callosum) and long-term behavioral outcomes in juvenile (P38-50) and adult (P80+) periods across two independent learning domains (spatial and non-spatial learning), after postnatal day 7 HI injury in rats. Here, for the first time, we show that IAIPs reduce acute neocortical neuronal cell death and improve brain weight outcome 72 hours following HI injury in the neonatal rat. Further, these longitudinal studies are the first to show age, task and treatment dependent improvements in behavioral outcome for both spatial and non-spatial learning following systemic administration of IAIPs in neonatal HI injured rats. Finally, results also show sparing of brain regions critical for spatial and non-spatial learning in adult animals treated with IAIPs at the time of injury onset. These data support the proposal that Inter-alpha Inhibitor Proteins may serve as novel therapeutics for brain injury associated with premature birth and/or neonatal brain injury and highlight the importance of assessing multiple ages, brain regions and behavioral domains when investigating experimental treatment efficacy.

show abstract

“…Processing of rapid, successive auditory stimuli has also been studied in rodents using both electrophysiological and behavioural paradigms (Fitch et al, 1994;Frenkel et al, 2000;Friedman et al 2004;Peiffer et al, 2004). Of course, animal models enable researchers to investigate the effects of induced lesions and malformations in a manner not possible with humans.…”

Section: Animal Studiesmentioning

confidence: 99%

Development of structure and function in the infant brain: Implications for cognition, language and social behaviour

Paterson

Heim

Friedman

et al. 2006

Neuroscience & Biobehavioral Reviews

View full text Add to dashboard Cite

Recent advances in cognitive neuroscience have allowed us to begin investigating the development of both structure and function in the infant brain. However, despite the rapid evolution of technology, surprisingly few studies have examined the intersection between brain and behaviour over the first years of life. Even fewer have done so in the context of a particular research question. This paper aims to provide an overview of four domains that have been studied using techniques amenable to elucidating the brain/behaviour interface: language, face processing, object permanence, and joint attention, with particular emphasis on studies focusing on early development. The importance of the unique role of development and the interplay between structure and function is stressed throughout. It is hoped that this review will serve as a catalyst for further thinking about the substantial gaps in our understanding of the relationship between brain and behaviour across development. Further, our aim is to provide ideas about candidate brain areas that are likely to be implicated in particular behaviours or cognitive domains.

show abstract

Age and experience-related improvements in gap detection in the rat

Cited by 53 publications

References 34 publications

Dyslexia—A molecular disorder of neuronal migration

Dyslexia—A molecular disorder of neuronal migration

Effects of inter-alpha inhibitor proteins on neonatal brain injury: Age, task and treatment dependent neurobehavioral outcomes

Development of structure and function in the infant brain: Implications for cognition, language and social behaviour

Contact Info

Product

Resources

About