Age and gender specific pediatric reference intervals for aldolase, amylase, ceruloplasmin, creatine kinase, pancreatic amylase, prealbumin, and uric acid

Pediatric Within-Day Biological Variation and Quality Specifications for 38 Biochemical Markers in the CALIPER Cohort

“…Previous studies have determined that measurements made 24 h apart had smaller CV I values than those taken at intervals of 4 days or longer (17 ). Additionally, an increased CV G for pediatric vs adult populations was observed for 5 analytes, which may indicate a need for further age and/or sex partitioning, as previously demonstrated by reference interval studies (18 ). Only 4 analytes, CRP, GGT, ceruloplasmin, and glucose, showed marked differences in both within-and between-person variation in the pediatric vs the adult populations (Table 2).…”

Closing the Gaps in Pediatric Laboratory Reference Intervals: A CALIPER Database of 40 Biochemical Markers in a Healthy and Multiethnic Population of Children

“…Some of these studies used samples from hospital clinic patients (30 ), and others determined reference intervals from small sample sizes (31,32 ) or a homogeneous population (33 ). Although several pediatric reference interval studies have recruited healthy children, many of these studies have focused on only a few analytes (34 ) or were conducted many years ago on outdated instrumentation (31,32 ).…”

Important considerations for interpreting biochemical tests in children

“…- Resources for paediatric reference intervals include data from the KiGGS study in Germany,3 the CHILDx study in the United States,4 Australian Harmonised Reference Intervals for Paediatrics (AHRIP),5 the Nordic paediatric reference interval study,6 the Tietz textbook,7 and the CALIPER study in Canada 8…”

“…This could lead to missed diagnosis, misdiagnosis, or unnecessary follow-up 14. Several initiatives have begun to establish accurate paediatric reference intervals,34681415 providing important lessons for practising clinicians on interpreting blood tests. The authors have worked on a nationwide paediatric reference interval project, the Canadian Laboratory Initiative on Paediatric Reference Intervals (CALIPER), which highlights the requirement of several age- and sex-specific reference interval partitions 8…”