“…Many factors may contribute to the increased differences between sexes in fracture rates with ageing, including differences in bone strength [29,30], propensity to fall [26], and the load placed on the bone [31]. The gradient of fracture risk by age varies not only by sex, but also by skeletal site [28,32]. Of note, we used a composite outcome combining fractures occurring at different skeletal sites, and as such, we cannot comment on the relationships between age, sex and skeletal site.…”