Age- and genotype-related neurophysiologic reactivity to oxidative stress in healthy adults

Ponomareva, Natalia; Goltsov, Alexei A.; Scheglova, Nadejda; Malina, Daria; Mitrofanov, Andrey; Boikova, Tatiana I.; Rogaev, Evgeny I.

doi:10.1016/j.neurobiolaging.2011.11.013

Cited by 7 publications

(6 citation statements)

References 54 publications

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“…Babiloni et al [19] found that MCI and AD patients carrying the 4 allele showed lower alpha 1 and alpha 2 amplitudes in occipital, temporal, and limbic areas. Ponomareva et al [56] investigated EEG patterns in AD patients and their unaffected relatives who were divided into carriers and non-carriers of the 4 allele. During the resting state condition, AD-4 carriers showed lower alpha power, and no differences were found in the relatives group.…”

Section: Discussionmentioning

confidence: 99%

Source Analysis of Spontaneous Magnetoencephalograpic Activity in Healthy Aging and Mild Cognitive Impairment: Influence of Apolipoprotein E Polymorphism

Cuesta

Barabash

Aurtenetxe

et al. 2014

JAD

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The apolipoprotein E (APOE) ε4 allele is a genetic risk factor for the development of late-onset Alzheimer's disease (AD), which affects cholinergic system functioning. The association between reduced cholinergic levels and increase of magnetoencephalographic (MEG) low-frequency has been used to explain spectral changes found in AD patients. However, the investigation in predementia stages is scarce. We obtained MEG recordings from 25 aged controls and 36 mild cognitive impairment (MCI) patients during a resting-state condition. According to their APOE genotype, MCIs and controls were subdivided in carriers and non-carriers of the ε4 allele. Sources of spectral variations in these groups were calculated through beamforming. MCI patients exhibited a significant increase of relative power within the low-frequency domain, accompanied by a power decrease within the high-frequency range. APOEε4 carriers showed an increased relative power in the 4.5-6.5 Hz frequency range over frontal lobes. The power increase observed in controls carrying ε4 was significantly higher as compared with MCI non-carriers, while MCI carriers exhibited the highest relative power within the 4.5-6.5 Hz range. Higher power values within the low-frequency ranges correlated with a poorer cognitive performance in MCIs and controls. Our investigation demonstrates that APOEε4 affects resting-state activity to an extent that makes it more proximate to the pattern observed in early stages of AD. Therefore, a combination of genetic and neurophysiological information might help to detect MCI patients at higher risk of conversion to AD, and asymptomatic subjects at higher risk of developing a manifest cognitive deterioration.

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Section: Discussionmentioning

confidence: 99%

Source Analysis of Spontaneous Magnetoencephalograpic Activity in Healthy Aging and Mild Cognitive Impairment: Influence of Apolipoprotein E Polymorphism

Cuesta

Barabash

Aurtenetxe

et al. 2014

JAD

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“…The effect of aging on EEG is modulated by genetic factors (Babiloni et al, 2006b; Ponomareva et al, 2012). Several lines of evidence imply that the effect of CLU genotype on brain function may be observed before the onset of cognitive impairment.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have demonstrated the association between the AD genetic risk variant ApoE ε4 and EEG in patients with AD, MCI, and healthy subjects (Jelic et al, 1997; Lehtovirta et al, 2000; Babiloni et al, 2006b; Ponomareva et al, 2008, 2012; Lee et al, 2012). It was shown that AD patients carrying the ApoE ε4 genotype have lower alpha power and lower alpha coherence as compared to non-carriers (Jelic et al, 1997; Lehtovirta et al, 2000; Ponomareva et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Age-dependent effect of Alzheimer’s risk variant of CLU on EEG alpha rhythm in non-demented adults

Ponomareva

Andreeva

Protasova

et al. 2013

Front. Aging Neurosci.

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Polymorphism in the genomic region harboring the CLU gene (rs11136000) has been associated with the risk for Alzheimer’s disease (AD). CLU C allele is assumed to confer risk for AD and the allele T may have a protective effect. We investigated the influence of the AD-associated CLU genotype on a common neurophysiological trait of brain activity (resting-state alpha-rhythm activity) in non-demented adults and elucidated whether this influence is modified over the course of aging. We examined quantitative electroencephalography (EEG) in a cohort of non-demented individuals (age range 20–80) divided into young (age range 20–50) and old (age range 51–80) cohorts and stratified by CLU polymorphism. To rule out the effect of the apolipoprotein E (ApoE) genotype on EEG characteristics, only subjects without the ApoE ε4 allele were included in the study. The homozygous presence of the AD risk variant CLU CC in non-demented subjects was associated with an increase of alpha3 absolute power. Moreover, the influence of CLU genotype on alpha3 was found to be higher in the subjects older than 50 years of age. The study also showed age-dependent alterations of alpha topographic distribution that occur independently of the CLU genotype. The increase of upper alpha power has been associated with hippocampal atrophy in patients with mild cognitive impairment (Moretti etal., 2012a). In our study, the CLU CC-dependent increase in upper alpha rhythm, particularly enhanced in elderly non-demented individuals, may imply that the genotype is related to preclinical dysregulation of hippocampal neurophysiology in aging and that this factor may contribute to the pathogenesis of AD.

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“…There are promising EEG candidate biomarkers of preclinical AD including reduction of functional cortical connectivity (Babiloni et al, 2018). Recent studies have shown an association between EEG alpha rhythm alterations and AD risk variant in the ApoE gene in AD, MCI patients and even in healthy adults (Lizio et al, 2011, review;Ponomareva et al, 2008Ponomareva et al, , 2012.…”

Section: Discussionmentioning

confidence: 99%

Genetic Association Between Alzheimer’s Disease Risk Variant of the PICALM Gene and EEG Functional Connectivity in Non-demented Adults

et al. 2020

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Genome wide association studies (GWAS) have identified and validated the association of the PICALM genotype with Alzheimer's disease (AD). The PICALM rs3851179 A allele is thought to have a protective effect, whereas the G allele appears to confer risk for AD. The influence of the PICALM genotype on brain functional connectivity in non-demented subjects remains largely unknown. We examined the association of the PICALM rs3851179 genotype with the characteristics of lagged linear connectivity (LLC) of resting EEG sources in 104 non-demented adults younger than 60 years of age. The EEG analysis was performed using exact low-resolution brain electromagnetic tomography (eLORETA) freeware (Pascual-Marqui et al., 2011). We found that the carriers of the A PICALM allele (PICALM AA and AG genotypes) had higher widespread interhemispheric LLC of alpha sources compared to the carriers of the GG PICALM allele. An exploratory correlation analysis showed a moderate positive association between the alpha LLC interhemispheric characteristics and the corpus callosum size and between the alpha interhemispheric LLC characteristics and the Luria word memory scores. These results suggest that the PICALM rs3851179 A allele provides protection against cognitive decline by facilitating neurophysiological reserve capacities in nondemented adults. In contrast, lower functional connectivity in carriers of the AD risk variant, PICALM GG, suggests early functional alterations in alpha rhythm networks.

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Age- and genotype-related neurophysiologic reactivity to oxidative stress in healthy adults

Cited by 7 publications

References 54 publications

Source Analysis of Spontaneous Magnetoencephalograpic Activity in Healthy Aging and Mild Cognitive Impairment: Influence of Apolipoprotein E Polymorphism

Source Analysis of Spontaneous Magnetoencephalograpic Activity in Healthy Aging and Mild Cognitive Impairment: Influence of Apolipoprotein E Polymorphism

Age-dependent effect of Alzheimer’s risk variant of CLU on EEG alpha rhythm in non-demented adults

Genetic Association Between Alzheimer’s Disease Risk Variant of the PICALM Gene and EEG Functional Connectivity in Non-demented Adults

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