Age- and hormone-related changes in vaginal smear patterns in the gray-tailed vole, Microtus canicaudus

Petersen, Sandra L.

doi:10.1530/jrf.0.0780049

Cited by 6 publications

(6 citation statements)

References 29 publications

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“…Therefore, both the incidence of vaginal oestrus and the rate of reproductive success increase with age. These results are consistent with the hypothesis that the changes in vaginal smear patterns previously reported in gray-tailed voles represent maturational changes (Petersen, 1986).…”

Section: Discussionsupporting

confidence: 93%

“…Previous studies demonstrated that female gray-tailed voles isolated from males after weaning experience age-related increases in the incidence of vaginal cornification (Petersen, 1986). The results of the present studies demonstrate that isolated females also experience age-related increases in plasma oestrogen concentrations, behavioural receptivity, and the incidence of fertile matings.…”

Section: Discussionmentioning

confidence: 99%

“…Radioimmunoassay s for oestrogen and progesterone. Plasma samples were assayed for oestrogen as previously described (Korenman et al, 1974;Petersen, 1986). The sensitivity of the assay was 2-5 pg per tube or 25 pg/ml when 100 µ samples were used.…”

Section: Methodsmentioning

confidence: 99%

“…Progesterone was assayed in 25 µ duplicate aliquants of plasma using general procedures previously described (Koligian & Stormshak, 1977;Petersen, 1986). The sensitivity of the assay was 7-8 pg/tube or 312 pg/ml in 25 µ samples.…”

Section: Methodsmentioning

confidence: 99%

“…Female gray-tailed voles, M. canicaudus, show age-related changes in vaginal smear patterns (Petersen, 1986). At 30-50 days of age, females generally exhibit persistently leucocytic vaginal smears; cornified smears are rarely seen.…”

Section: Introductionmentioning

confidence: 99%

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Age-related changes in plasma oestrogen concentration, behavioural responsiveness to oestrogen, and reproductive success in female gray-tailed voles, Microtus canicaudus

Petersen¹

1986

Reproduction

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Age-related increases in the incidence of vaginal cornification were associated with increases in the reproductive success of female gray-tailed voles previously isolated from males. The pregnancy rate of females first paired with males at 30-50 days of age was significantly lower than that of females first paired at 90-120 or 150-200 days of age. The improvement was due to increases in propensities to display receptive behaviours and decreases in the incidence of sterile matings. Although plasma oestrogen concentrations increased with age and were higher in receptive than unreceptive females, plasma oestrogen values alone did not account completely for differences in receptive behaviours amongst females of different ages. Females ovariectomized at 30-50 days of age rarely displayed receptive behaviours when treated with large doses of oestradiol benzoate, whereas nearly all females similarly treated were receptive if ovariectomies were performed between 150 and 200 days of age. The receptivity rate of females ovariectomized between 90 and 150 days was intermediate between the rates of the other two groups.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations