Age- and menopause-related differences in physiological factors of health quality in women aged 35–60

Wiącek, Magdalena; Jegal, Bo Seul; Hagner, Wojciech; Hagner‐Derengowska, Magdalena; Zubrzycki, Igor Z.

doi:10.1016/j.archger.2011.04.011

Cited by 10 publications

(8 citation statements)

References 48 publications

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“…In the 1999–2002 NHANES datasets, serum FSH and LH concentrations (mIU/mL) were measured by a microparticle enzyme immunoassay technology (IMx FSH assay, IMx LH assay, Abbott Laboratories)(25, 26). This study relied on FSH and LH measurements to compute the LH/FSH ratio, the exposure of interest.…”

Section: Methodsmentioning

confidence: 99%

Relationship of obesity-related disturbances with LH/FSH ratio among post-menopausal women in the United States

Beydoun

Wiggins

et al. 2012

Maturitas

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Objectives Although luteinizing hormone to follicular stimulating hormone (LH/FSH) ratio is a controversial criterion for identifying a sub-group of infertile women with polycystic ovary syndrome (PCOS) and abnormalities at the level of the hypothalamic-pituitary-ovarian axis, an elevated LH/FSH ratio is frequently observed in PCOS cases. Obesity and insulin resistance are highly prevalent among PCOS women. To date, no studies have examined the associations of LH/FSH ratio with these co-morbid conditions outside the context of pre- and peri-menopausal PCOS women. The objective of this study is to evaluate whether the LH/FSH ratio is associated with obesity, insulin resistance, metabolic disturbances and chronic inflammation among post-menopausal U.S. women, 35 to 60 years of age. Study Design Cross-sectional study of 693 women who participated in the 1999–2002 National Health and Nutrition Examination Survey. Main Outcome Measures body mass index, waist circumference, triglycerides, high-density lipoprotein (HDL) cholesterol, systolic and diastolic blood pressures, fasting glucose, metabolic syndrome, Homeostasis Model Assessment for Insulin Resistance and C-reactive protein (CRP). Results Age- and hysterectomy-adjusted regression models suggest that CRP level is positively associated with LH/FSH ratio and LH/FSH >1, high glucose level and LH/FSH>2 are inversely related and HDL<50 mg/dL is positively associated with both LH/FSH>1 and LH/FSH>2. Conclusions In a nationally representative sample of post-menopausal women, markers of chronic inflammation and dyslipidemia which are characteristics of PCOS-associated morbidities were also significantly associated with LH/FSH ratio, meriting further investigation.

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Section: Methodsmentioning

confidence: 99%

Relationship of obesity-related disturbances with LH/FSH ratio among post-menopausal women in the United States

Beydoun

Wiggins

et al. 2012

Maturitas

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“…About 45.8% women in Chandigarh (Ahlawat, Singh, Kumar, Kumari, & Sharma, 2002) and 37.5% women in Jaipur (Gupta et al, 2002) were found to be hypertensive. Various factors such as aging (Wiacek, Jegal, Hagner, Hagner-Derengowsk, & Zubrzycki, 2012) and fatness have been found to be some of the leading factors for physiological variability in blood pressure. Blood pressure was found to increase with fatness and advancing age (Tyagi & Kapoor, 1999, 2010).…”

Section: Introductionmentioning

confidence: 99%

Bio-Social Predictors of Hypertension Among Premenopausal and Postmenopausal Women

Tyagi¹,

Dhall

Kapoor

2015

Sage Open

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In the present study, the contribution of various biological and lifestyle factors toward progression to hypertension are examined among menopausal and postmenopausal women. A cross-sectional study among 245 women of 20 to 65 years was conducted. Besides blood pressure, fat percentage using bio-electric impedance analyzer and adiposity indices such as body mass index (BMI), waist-hip ratio (WHR), and waist-height ratio (WHtR) were taken. Mean, standard deviation, ANOVA, and multinomial logistic were used to analyze the data. Statistically significant differences (p< .001) for blood pressure among postmenopausal and premenopausal women were found. Among both premenopausal and postmenopausal women, the prehypertensive and hypertensive group showed significant differences with the normotensive women for body weight (p< .005), regional obesity, and general obesity. Low educational level, working status of women, socioeconomic status, nuclear family setup, postmenopausal status, and obesity were found to be the likely risk factors for prehypertension or hypertension among women.

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“…Some studies have found a signi fi cant [ 12,34 ] and progressive [ 45 ] increase in levels of the protective serum high-density lipoprotein cholesterol during the menopausal process, though one study [ 46 ] found a decrease during the 2 years preceding menopause and some [ 5 ] have found no change. After the fi nal menstrual period, the level of HDL-C usually begins to decline, often reaching the perimenopausal level [ 11 ] .…”

Section: 2 )mentioning

confidence: 99%

“…An analysis of the current literature reveals slight inconsistencies regarding changes in TC level as a function of the menopausal transition. The vast majority of reports [ 33,34 ] indicate that the transition between perimenopause and postmenopause is associated with an increase in TC levels. However, Franklin et al [ 33 ] reported a lack of menopause-induced changes in TC level.…”

Section: Total Cholesterolmentioning

confidence: 99%

Menopause-Related Physiological Changes and Their Possible Control Through Diet and Exercise

Zubrzycki

Wiącek

Greiner

2013

Nutrition and Diet in Menopause

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Age- and menopause-related differences in physiological factors of health quality in women aged 35–60

Cited by 10 publications

References 48 publications

Relationship of obesity-related disturbances with LH/FSH ratio among post-menopausal women in the United States

Relationship of obesity-related disturbances with LH/FSH ratio among post-menopausal women in the United States

Bio-Social Predictors of Hypertension Among Premenopausal and Postmenopausal Women

Menopause-Related Physiological Changes and Their Possible Control Through Diet and Exercise

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