Age- and Occupation-Based Public Health Considerations Related to Osteoarthritis of the Knee Joint: A Cadaveric Study

Immonen, Jessica; Siefring, Chris

doi:10.1177/1947603517752432

Cited by 5 publications

(4 citation statements)

References 42 publications

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“…Osteoarthritis is a common degenerative joint disease, and the knee is the most common joint affected ( 16 ). Quantifying both incidence rates and burden is important ( 17 ).…”

Section: Discussionmentioning

confidence: 99%

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Global burden and socioeconomic impact of knee osteoarthritis: a comprehensive analysis

Li,

Tan,

et al. 2024

Front. Med.

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ObjectiveTo report the trend changes of the prevalence, incidence, and disability-adjusted life years (DALYs) of knee osteoarthritis (KOA) according to age, sex, sociodemographic index (SDI), and income.MethodsThis analysis used estimates from the broader Global Burden of Disease (GBD) study 2019, which covered 201 countries from 1990 to 2019. National prevalence, incidence, and DALYs were shown by using ggplot2 and maps packages. Five-year intervals were used for age groupings. The Commonwealth and the World Bank income classifications were used for income grouping.ResultsGlobally, there were ~364.58 million prevalent cases (females: 225.16 million), 29.51 million incident cases (females: 17.53 million), and 11.53 million DALYs (females: 7.09 million) due to KOA in 2019. The Western Pacific Region had a high endemicity of ~7,319.87 cases per 100,000 people (7.64%). Japan's prevalence rate (12,610.12 cases per 100,000 population) was 10 times that of Somalia (1,178.23) in 2019. In 200 countries (except the United Arab Emirates), the prevalence, incidence, and DALY rates of KOA in 2019 were higher among females than among males and increased with age up to the oldest age group. The prevalence was highest in the high-middle SDI countries, and the incidence and DALYs were highest in the middle SDI countries.ConclusionThere was a large burden of KOA worldwide, with some notable intercountry variation. Some countries had 10 times the burden of other countries. Increasing population awareness regarding the prevalence, incidence, and DALYs of KOA with a focus on the population in the Western Pacific Region is needed, particularly for older females. informs health policy development, and contributes to improving the efficiency, equity, and effectiveness of healthcare systems.

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“…Osteoarthritis is a common degenerative joint disease, and the knee is the most common joint affected ( 16 ). Quantifying both incidence rates and burden is important ( 17 ).…”

Section: Discussionmentioning

confidence: 99%

“…These data highlight the significant but underrecognized global burden of KOA. Osteoarthritis is a common degenerative joint disease, and the knee is the most common joint affected (16). Quantifying both incidence rates and burden is important (17).…”

Section: Discussionmentioning

confidence: 99%

Global burden and socioeconomic impact of knee osteoarthritis: a comprehensive analysis

Li,

Tan,

et al. 2024

Front. Med.

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“…It has been documented in previous morphometric studies that the ACL grossly thins with aging. 7,31 It was not determined in individual specimens if thinning of the ACL leads to shearing or if shearing participates in the mechanical stretch of the ACL. This is an important determination as corrective measures and public health advisory could be improved with this information.…”

Section: Discussionmentioning

confidence: 99%

“…This is an important determination as corrective measures and public health advisory could be improved with this information. 31 If shearing stretches the ACL, maintenance and ideally hypertrophy of musculature supporting the joint becomes critical. If histological changes to the ACL produce stretch, then other metabolic and signaling systems needs to be investigated to reduce the propensity for patients to experience ACL degeneration.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Degree of Osteoarthritis in Aging Male and Female Femoral Condyles: A Cadaveric Study

et al. 2020

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Objective Determine if femoral chondral cartilage degeneration on cadaveric knee joints exacerbate differently with aging between the sexes. Methods A total of 85 cadaveric femurs were assessed for macroscopic femoral condyle pathology using a scale for gross signs of osteoarthritis. Raters scored specimens and raters’ scores were averaged to provide each specimen a Disease Severity Score (DSS). Results The DSS for the 80+-year-old population was greater than the DSS of the 70- to 79-year-old population (* P < 0.05) and the <70-year-old population (** P < 0.01). Specimens that scored a DSS of 2 and higher were assessed for their specific site of most severe degeneration. The most severe degeneration on the articular cartilage was most regularly on the patellar fossa. The second most degenerated region varied by age and biomechanical alterations. There were no significant changes in DSS between the sexes within the age groups. Conclusions No difference was shown between the sexes in the severity or location of degeneration indicating that men and women are likely affected by the same biomechanical changes that spur on osteoarthritis in their eighth decade of life (70s) and later. Lateral femoral degeneration predominates in younger populations. When patients approach their 70s, medial degeneration begins to predominate likely based on an increase in shearing at the knee joint.

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Retention of peptide-based vesicles in murine knee joints after intra-articular injection

Dunshee

McDonough

Price

et al. 2022

Journal of Drug Delivery Science and Technology

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Age- and Occupation-Based Public Health Considerations Related to Osteoarthritis of the Knee Joint: A Cadaveric Study

Cited by 5 publications

References 42 publications

Global burden and socioeconomic impact of knee osteoarthritis: a comprehensive analysis

Global burden and socioeconomic impact of knee osteoarthritis: a comprehensive analysis

Assessment of the Degree of Osteoarthritis in Aging Male and Female Femoral Condyles: A Cadaveric Study

Retention of peptide-based vesicles in murine knee joints after intra-articular injection

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