Age and pain differences in non-verbal fluency performance: Associations with cortical thickness and subcortical volumes

Lysne, P.; Cohen, Ronald A.; Hoyos, Lorraine; Fillingim, Roger B.; Riley, Joseph L.; Cruz-Almeida, Yenisel

doi:10.1016/j.exger.2019.110708

Cited by 12 publications

(5 citation statements)

References 43 publications

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“…We have previously reported on various aspects of the NEPAL study participants and its detailed methodology. 5 , 8 , 9 , 31 To address the aims of this study, we included assessments of self-reported pain, depressive symptoms, a quantitative sensory testing battery, and MRS neuroimaging obtained from 3 separate laboratory visits.…”

Section: Methodsmentioning

confidence: 99%

Brain gamma-aminobutyric acid, but not glutamine and glutamate levels are lower in older adults with chronic musculoskeletal pain: considerations by sex and brain location

Cruz-Almeida

Forbes

Cohen

et al. 2021

PR9

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Section: Methodsmentioning

confidence: 99%

Brain gamma-aminobutyric acid, but not glutamine and glutamate levels are lower in older adults with chronic musculoskeletal pain: considerations by sex and brain location

Cruz-Almeida

Forbes

Cohen

et al. 2021

PR9

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“…Detailed information about the NEPAL participants have been previously reported. [24][25][26][27] Table 1 summarizes demographic characteristics of the study participants (n ¼ 31). Chronic pain participants experienced musculoskeletal pain of at least 3 months duration that significantly impacted their life on most days; pain was most commonly reported on the back and the knee/leg region.…”

Section: Resultsmentioning

confidence: 99%

Chronic Pain is Associated With Reduced Sympathetic Nervous System Reactivity During Simple and Complex Walking Tasks: Potential Cerebral Mechanisms

et al. 2021

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Background Autonomic dysregulation may lead to blunted sympathetic reactivity in chronic pain states. Autonomic responses are controlled by the central autonomic network (CAN). Little research has examined sympathetic reactivity and associations with brain CAN structures in the presence of chronic pain; thus, the present study aims to investigate how chronic pain influences sympathetic reactivity and associations with CAN brain region volumes. Methods Sympathetic reactivity was measured as change in skin conductance level (ΔSCL) between a resting reference period and walking periods for typical and complex walking tasks (obstacle and dual-task). Participants included 31 people with (n = 19) and without (n = 12) chronic musculoskeletal pain. Structural 3 T MRI was used to determine gray matter volume associations with ΔSCL in regions of the CAN (i.e., brainstem, amygdala, insula, and anterior cingulate cortex). Results ΔSCL varied across walking tasks (main effect p = 0.036), with lower ΔSCL in chronic pain participants compared to controls across trials 2 and 3 under the obstacle walking condition. ΔSCL during typical walking was associated with multiple CAN gray matter volumes, including brainstem, bilateral insula, amygdala, and right caudal anterior cingulate cortex (p’s < 0.05). The difference in ΔSCL from typical-to-obstacle walking were associated with volumes of the midbrain segment of the brainstem and anterior segment of the circular sulcus of the insula (p’s < 0.05), with no other significant associations. The difference in ΔSCL from typical-to-dual task walking was associated with the bilateral caudal anterior cingulate cortex, and left rostral cingulate cortex (p’s < 0.05). Conclusions Sympathetic reactivity is blunted during typical and complex walking tasks in persons with chronic pain. Additionally, blunted sympathetic reactivity is associated with CAN brain structure, with direction of association dependent on brain region. These results support the idea that chronic pain may negatively impact typical autonomic responses needed for walking performance via its potential impact on the brain.

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“…This is a secondary data analysis as we have previously reported detailed information from our Nepal participants. 30,31 Health Assessment Session A clinical research coordinator obtained written informed consent followed by demographic and general health and pain history information containing non-pathological personal history (ie, diet, exercise and toxic habits like smoking, alcohol, and caffeine use) and personal pathological history (ie, existing systemic diseases, existing sleep disorders like obstructive sleep apnea, restless legs syndrome, narcolepsy and insomnia; previous surgeries or hospitalizations and all medications taken). For the present study, participants that reported any medical condition in the health history questionnaire related to any sleep disorder were excluded.…”

Section: Materials and Methods Participantsmentioning

confidence: 99%

“…As previously reported, 30,31 all QST procedures were performed in a quiet room (temperature 21°C-23°C) with subjects seated in a comfortable chair with armrests and a semi-reclining back. An overview of the testing procedures was explained to the subject and for each different modality, specific instructions were delivered immediately before beginning the test.…”

Section: Quantitative Sensory Testing (Qst) Sessionmentioning

confidence: 99%

<p>Cortical Thickness Mediates the Association Between Self-Reported Pain and Sleep Quality in Community-Dwelling Older Adults</p>

Montesino-Goicolea

Valdés-Hernández

Hoyos

et al. 2020

JPR

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Introduction: Musculoskeletal pain is prevalent in older adults representing the leading cause of disability in this population. Similarly, nearly half of older adults complain of difficulty sleeping. We aimed to explore the relationship between sleep quality with selfreported musculoskeletal pain, somatosensory and pain thresholds in community-dwelling older adults and further explore brain regions that may contribute to this association. Methods: Older adults (>60 years old, n=69) from the NEPAL study completed demographic, pain and sleep assessments followed by a quantitative sensory testing battery. A subset (n=49) also underwent a 3T high-resolution, T1-weighted anatomical scan. Results: Poorer sleep quality using the Pittsburgh Sleep Quality Index was positively associated with self-reported pain measures (all p's >0.05), but not somatosensory and pain thresholds (all p's >0.05). Using a non-parametric threshold-free cluster enhancement (TFCE) approach, worse sleep quality was significantly associated with lower cortical thickness in the precentral, postcentral, precuneus, superior parietal, and lateral occipital regions (TFCE-FWE-corrected at p < 0.05). Further, only postcentral cortical thickness significantly mediated the association between sleep quality and self-reported pain intensity using bootstrapped mediation methods. Conclusion: Our findings in older adults are similar to previous studies in younger individuals where sleep is significantly associated with self-reported pain. Specifically, our study implicates brain structure as a significant mediator of this association in aging. Future larger studies are needed to replicate our findings and to further understand if the brain can be a therapeutic target for both improved sleep and pain relief in older individuals.

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Age and pain differences in non-verbal fluency performance: Associations with cortical thickness and subcortical volumes

Cited by 12 publications

References 43 publications

Brain gamma-aminobutyric acid, but not glutamine and glutamate levels are lower in older adults with chronic musculoskeletal pain: considerations by sex and brain location

Brain gamma-aminobutyric acid, but not glutamine and glutamate levels are lower in older adults with chronic musculoskeletal pain: considerations by sex and brain location

Chronic Pain is Associated With Reduced Sympathetic Nervous System Reactivity During Simple and Complex Walking Tasks: Potential Cerebral Mechanisms

<p>Cortical Thickness Mediates the Association Between Self-Reported Pain and Sleep Quality in Community-Dwelling Older Adults</p>

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