Age and Serum-Alkaline-Phosphatase

Liver disease in rheumatoid arthritis and Sjogren's syndrome. Prospective study using biochemical and serological markers of hepatic dysfunction.

“…Certainly this may account for raised serum alkaline phosphatase levels during youth (Clark and Beck, 1950), and for this reason we excluded patients with juvenile 78 Annals of the Rheumatic Diseases rheumatoid arthritis from the study. Minimal rises of serum alkaline phosphatase levels have also been reported in some normal persons over 60 years of age (Klaassen, 1966), but in view of their negligible magnitude we doubt the relevance of this in the present context.…”

Fever of Unknown Origin in the Elderly

“…For example, healthy older persons have lower hemoglobin and hematocrit levels than do younger persons and their total leukocyte and differential counts range more widely (24). Similarly, to the long list of processes such as Hodgkin's disease (26) and giant‐cell arteritis (27) which nonspecifically elevate serum alkaline phosphatase activity must be added age (28). In this series an abnormal alkaline phosphatase value was frequently noted, and invasive procedures such as liver biopsy apparently were performed on the basis of that finding alone.…”

Alkaline Phosphatases in Biology and Medicine

“…In the third trimester of gestation, maternal placental AP represents a significant propor tion of the total plasma AP [53]. In adult males the AP in plasma is slightly higher than in females [54,55].…”