Age and sex differences in hearing loss association with depressive symptoms: analyses of NHANES 2011–2012

Scinicariello, Franco; Przybyla, Jennifer; Carroll, Yulia; Eichwald, John; Decker, John; Breysse, Patrick N.

doi:10.1017/s0033291718001617

Cited by 40 publications

(40 citation statements)

References 37 publications

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“…In a community sample of 5832 subjects from Korea, self‐reported hearing loss was associated with significantly higher prevalence of depression and this association was magnified among those with dual hearing and visual impairment [65]. The United States National Health And Nutrition Examination Survey (NHANES) survey data showed that hearing loss was associated with increased frequency of depression using the PHQ‐9 measurement [66]. Another investigation based on clinical interviews with parents in Austria showed that the point and lifetime prevalence of depression were higher in a representative sample of deaf schoolchildren than in children without hearing loss [34].…”

Section: Discussionmentioning

confidence: 99%

The relationship between mental health conditions and hearing loss in low‐ and middle‐income countries

Jiang

Kubwimana

Eaton

et al. 2020

Tropical Med Int Health

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objective Hearing loss can have far-reaching effects on social, emotional and cognitive development, but few studies have addressed the link with mental health conditions. We conducted a systematic review of the association between hearing loss and mental health conditions in low-and middle-income countries (LMICs).methods We searched six electronic databases using predetermined criteria to retrieve original research reporting mental health in people with hearing loss. We considered quantitative studies measuring any type of mental health conditions according to the ICD10 classifications of 'Mental and behavioural disorders' in relation to any measure of hearing loss. We assessed risk of bias using a set of criteria according to the SIGN50 guidelines.results We included 12 studies evaluating 35 604 people with hearing loss in 10 countries. Poorer mental health (measured as stress and anxiety, depression, and/or behavioural and emotional disorders) was more common among people with hearing loss compared to those without in 10 studies. One study found no difference in mental health outcomes between people with hearing, visual and no impairment. Another study reported that after hearing aids, those with severe hearing loss had significant improvement in psychosocial function, compared to no change among those without hearing loss. Overall, one study was judged to be high quality, seven medium quality and four low quality.conclusions Included studies showed a trend towards poorer mental health outcomes for people with hearing loss than for those without. However, our findings indicate that very few high-quality studies have been conducted in LMICs.keywords hearing loss, mental health, low-and middle-income countries Sustainable Development Goals (SDGs): SDG 3 (good health and well-being), SDG 10 (reduced inequalities), SDG 17 (partnerships for the goals)

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Section: Discussionmentioning

confidence: 99%

The relationship between mental health conditions and hearing loss in low‐ and middle‐income countries

Jiang

Kubwimana

Eaton

et al. 2020

Tropical Med Int Health

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“…In patients, it has been shown that auditory cortex activation and auditory perception and processing are impaired in depression (Zwanzger et al, 2012; Bonetti et al, 2017; Zweerings et al, 2019). Moreover, age-related hearing loss has been associated with late life depression (Husain et al, 2014; Rutherford et al, 2018; Scinicariello et al, 2019), and in animals, chronic restraint stress decreased glucose metabolism in the auditory cortex (Wei et al, 2018). It would be relevant to know whether antidepressant medication reverts auditory dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Chronic Fluoxetine Treatment Induces Maturation-Compatible Changes in the Dendritic Arbor and in Synaptic Responses in the Auditory Cortex

et al. 2019

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Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) used to treat mood and anxiety disorders. Chronic treatment with this antidepressant drug is thought to favor functional recovery by promoting structural and molecular changes in several forebrain areas. At the synaptic level, chronic fluoxetine induces an increased size and density of dendritic spines and an increased ratio of GluN2A over GluN2B N-methyl-D-aspartate (NMDA) receptor subunits. The “maturation”-promoting molecular changes observed after chronic fluoxetine should also induce structural remodeling of the neuronal dendritic arbor and changes in the synaptic responses. We treated adult rats with fluoxetine (0.7 mg/kg i.p. for 28 days) and performed a morphometric analysis using Golgi stain in limbic and nonlimbic cortical areas. Then, we focused especially on the auditory cortex, where we evaluated the dendritic morphology of pyramidal neurons using a 3-dimensional reconstruction of neurons expressing mRFP after in utero electroporation. With both methodologies, a shortening and decreased complexity of the dendritic arbors was observed, which is compatible with an increased GluN2A over GluN2B ratio. Recordings of extracellular excitatory postsynaptic potentials in the auditory cortex revealed an increased synaptic response after fluoxetine and were consistent with an enrichment of GluN2A-containing NMDA receptors. Our results confirm that fluoxetine favors maturation and refinement of extensive cortical networks, including the auditory cortex. The fluoxetine-induced receptor switch may decrease GluN2B-dependent toxicity and thus could be applied in the future to treat neurodegenerative brain disorders characterized by glutamate toxicity and/or by an aberrant network connectivity.

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“…At year 5, individuals with increased depressive symptoms had greater hearing loss measured by audiometric threshold for low-frequency and mid-frequency sounds compared with those with lower levels of depressive symptoms. In a study of NHANES data, both speech-frequency hearing loss and high-frequency hearing loss were associated with increased frequency of depression using the PHQ-9 (Scinicariello et al ., 2018).…”

Section: Hearing Loss and Psychiatric Disordersmentioning

confidence: 99%

Hearing loss and psychiatric disorders: a review

Blazer

Tucci

2018

Psychol. Med.

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Hearing loss is one of the most common yet unrecognized impairments experienced by adults, especially as they age. Mental health investigators and practitioners require better understanding of hearing loss, its association with psychiatric disorders, and the treatment of these disorders in the presence of hearing loss as well as the treatment of hearing loss itself. In this review, the authors briefly explore the global burden of hearing loss. Next we provide an overview of the extant literature on hearing loss associated with cognitive impairment, depression, anxiety disorders, psychoses, and quality of life with attention focused on the strength of the association, possible mechanisms explaining the association, data on treatment options specific to these disorders, and future research opportunities for these disorders. Current approaches to the treatment of hearing loss are presented, including hearing aids, rehabilitation including psychotherapies, surgical procedures (specifically cochlear implants), and induction loops connected to telecoils. Finally, cutting edge research into the pathophysiology and potential biological treatments of hearing loss is described.

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Age and sex differences in hearing loss association with depressive symptoms: analyses of NHANES 2011–2012

Cited by 40 publications

References 37 publications

The relationship between mental health conditions and hearing loss in low‐ and middle‐income countries

The relationship between mental health conditions and hearing loss in low‐ and middle‐income countries

Chronic Fluoxetine Treatment Induces Maturation-Compatible Changes in the Dendritic Arbor and in Synaptic Responses in the Auditory Cortex

Hearing loss and psychiatric disorders: a review

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