Age and Sex Influence the Use of Modular Femoral Components in Total Hip Arthroplasty Performed for Primary Osteoarthritis

Castagnini, Francesco; Bordini, Barbara; Cosentino, Monica; Liddo, Michele Di; Tella, Giuseppe; Masetti, Claudio; Traina, Francesco

doi:10.3390/jcm12030984

Cited by 6 publications

(3 citation statements)

References 21 publications

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“…Anthropometric variables such as height, weight, and foot length have been identified as potential indicators of the size of acetabular prostheses used in THA. Previous research has demonstrated a correlation between shoe size, height, weight, gender, and age with the size of knee and hip prostheses [ 12 , 13 ]. However, it is worth noting that no study to date has incorporated foot length as a variable in the prediction model.…”

Section: Discussionmentioning

confidence: 99%

Development and validation of multiple linear regression models for predicting total hip arthroplasty acetabular prosthesis

Zou,

Liu,

et al. 2024

J Orthop Surg Res

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Purpose To establish a multivariate linear equation to predict the diameter (outer diameter) of the acetabular prosthesis used in total hip arthroplasty. Methods A cohort of 258 individuals who underwent THA at our medical facility were included in this study. The independent variables encompassed the patients' height, weight, foot length, gender, age, and surgical access. The dependent variable in this study was the diameter of the acetabular prosthesis utilized during the surgical procedure. The entire cohort dataset was randomly partitioned into a training cohort and a validation cohort, with a ratio of 7:3, employing the SPSS 26.0 software. Pearson correlation analysis was conducted to examine the relationships between the patients' height, weight, foot length, gender, age, surgical access, and the diameter of the acetabular prosthesis in the training cohort. Additionally, a multiple linear regression equation was developed using the independent variables from the training cohort and the diameter of the acetabular prosthesis as the dependent variable. This equation aimed to predict the diameter of the acetabular prosthesis based on the patients' characteristics. The accuracy of the equation was evaluated by substituting the data of the validation cohort into the multiple linear equation. The predicted acetabular prosthesis diameters were then compared with the actual diameters used in the operation. Results The correlation analysis conducted on the training cohort revealed that surgical access (r = 0.054) and age (r = −0.120) exhibited no significant correlation with the diameter of the acetabular prosthesis utilized during the intraoperative procedure. Conversely, height (r = 0.687), weight (r = 0.654), foot length (r = 0.687), and sex (r = 0.354) demonstrated a significant correlation with the diameter of the acetabular prosthesis used intraoperatively. Furthermore, a predictive equation, denoted as Y (acetabular prosthesis diameter in mm) = 20.592 + 0.548 × foot length (cm) + 0.083 × height (cm) + 0.077 × weight (kg), was derived. This equation accurately predicted the diameter within one size with an accuracy rate of 64.94% and within two sizes with an accuracy rate of 94.81%. Conclusion Anthropometric data can accurately predict the diameter of acetabular prosthesis during total hip arthroplasty.

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Section: Discussionmentioning

confidence: 99%

Development and validation of multiple linear regression models for predicting total hip arthroplasty acetabular prosthesis

Zou,

Liu,

et al. 2024

J Orthop Surg Res

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“…Regarding the use of version-controlled neck and sex-based differences, Castagnini et al 19 reported that a version-controlled necks were prevalent in younger males and older females ( p < 0.001). Meanwhile, Gofton et al 9 reported no significant difference in neck selectivity as a sex-based function.…”

Section: Discussionmentioning

confidence: 99%

Sex-based differences in neck selectivity in total hip arthroplasty using a modular femoral neck system

Shigemura,

Kamikawa,

Yamamoto

et al. 2024

Int J Artif Organs

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Background: Dislocation is a major complication of total hip arthroplasty (THA). The modular femoral neck system provides practical advantages by allowing adjustment of neck version and length in the presence of intraoperative instability. Anatomical studies have identified morphological differences in the hip joint between men and women. Despite sex-based differences in hip morphology, it remains unclear whether such differences affect neck selectivity in THA using a modular neck system and whether this approach achieves anatomical reconstruction, thereby reducing complications such as dislocation. This study aimed to investigate gender differences in neck selectivity in THA with the modular neck system and assess the clinical impact of the modular neck system. Methods: A total of 163 THAs using a modular neck system were included in this study. Data on the type of modular neck and intraoperative range of motion (ROM) were retrieved from patient records. Pre- and post-operative leg length differences (LLD) were examined as part of the radiographic assessment. Dislocation was investigated as a postoperative complication. Results: Neck selectivity did not significantly differ between men and women. The comparison of pre- and post-operative LLD revealed a tendency for varus necks to improve LLD more than version-controlled necks. Furthermore, no significant correlation was found between intraoperative ROM and neck selectivity, or postoperative dislocation and neck selectivity. Conclusions: This study on THA with a modular neck system provided valuable insights into sex-based differences in neck selectivity and highlighted the potential benefits of the modular neck system in addressing LLD and preventing postoperative dislocation.

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“…Osteoarthritis (OA) is a chronic joint disorder linked to articular cartilage degeneration that affects numerous populations worldwide, especially the middle-aged and elderly people. [1][2][3] As a highly prevalent type of arthritis, $303 million people worldwide and 61.2 million patients in China had OA in 2017. 4,5 The risk factors of OA involve genetic susceptibility, obesity, severe joint damage, advanced age, and congenital deformities.…”

Section: Introductionmentioning

confidence: 99%

Silenced LASP1 interacts with DNMT1 to promote TJP2 expression and attenuate articular cartilage injury in mice by suppressing TJP2 methylation

Lian

Cheng

Kang

et al. 2023

The Kaohsiung J of Med Scie

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To investigate the regulatory mechanisms and effects of LIM and SH3 protein 1 (LASP1) on osteoarthritis (OA). IL‐1β was used to induce OA in cell models. Viability and apoptosis of chondrocytes were assessed. The expressions of tumor necrsis factor‐α (TNF‐α) and IL‐6 were measured by ELISA kit, and Quantitative reverse transcription polymerase chain reaction (qRT‐PCR) and Western blot were performed to test the expression of related proteins. The STRING database was used to predict the relationship between LASP1 and DNA methyltransferase 1 (DNMT1). The tight junction protein 2 (TJP2) and Gene Expression Omnibus data were analyzed for differential OA genes. Methylation‐specific PCR detected methylation of the TJP2 promoter region, and chromatin immunoprecipitation detected the enrichment of DNMT1 in the TJP2 promoter region. Safranin O‐Fast Green staining and hematoxylin and eosin staining were used to determine the OARSI score and evaluate the pathological conditions of the joint tissues. LASP1 was highly expressed in IL‐1β‐induced cell models. Silencing of LASP1 promoted chondrocyte proliferation and expression of Collagen II and Aggrecan and inhibited chondrocyte apoptosis, inflammatory factors, and matrix metalloprotein expression. TJP2 is weakly expressed in OA models, and LASP1 promotes methylation of the TJP2 promoter region by interacting with DNMT1. Silencing of LASP1 attenuated IL‐1β‐induced chondrocyte degeneration by promoting TJP2 expression. Similarly, silencing LASP1 promotes TJP2 expression to alleviate articular cartilage injury in mice with OA. Silencing of LASP1 inhibited the methylation of the TJP2 promoter region by interacting with DNMT1, thereby alleviating articular cartilage damage in OA mice.

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Age and Sex Influence the Use of Modular Femoral Components in Total Hip Arthroplasty Performed for Primary Osteoarthritis

Cited by 6 publications

References 21 publications

Development and validation of multiple linear regression models for predicting total hip arthroplasty acetabular prosthesis

Development and validation of multiple linear regression models for predicting total hip arthroplasty acetabular prosthesis

Sex-based differences in neck selectivity in total hip arthroplasty using a modular femoral neck system

Silenced LASP1 interacts with DNMT1 to promote TJP2 expression and attenuate articular cartilage injury in mice by suppressing TJP2 methylation

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