Age- and Sex-Specific Genomic Profiles in Non–Small Cell Lung Cancer

Mostertz, William

doi:10.1001/jama.2010.80

Cited by 57 publications

(39 citation statements)

References 39 publications

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“…Moreover association with sex of some phosphatidylcholines and sphingomyelins became nominally significant in both the univariate and the multivariate regression analysis only after including HDL cholesterol (Supplementary Table Men 2 High alcohol intake was defined as consuming more than 4 C2-units for men and 2 C2-units for women 3 Number of prevalent diseases including cancer, chronic disease, any form of diabetes, gallstones, heart attack, inflammatory bowel disease and neuropathy P values and regression coefficients (ß) derived from a linear regression analysis of log-transformed metabolite concentrations measured in 165 study participants (101 men, 64 women). All models were also additionally adjusted for age, waist-to-hip ratio, HDL cholesterol and smoking status 1 p adj denotes the p value adjusted for multiple testing by the Westfall and Young Step-Down MaxT procedure with 10,000 permutations 2 Δ denotes relative sex difference, defined as the difference in mean concentration between men and women, divided by the mean concentration in men …”

Section: Single-metabolite Analysismentioning

confidence: 99%

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Sex Dependency of Human Metabolic Profiles Revisited

Siegert¹

2012

Metabolomics

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Background: Human metabolic profiles based on the four compound classes acylcarnitines, amino acids, hexoses and phospho and sphingolipids were found to exhibit a significant sex difference in a previous study. We set out to verify this result in a geographically distinct cohort with an adequately sized sample by analyzing the same set of biomarkers and various additional biogenic amines not hitherto considered in such studies.

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Section: Single-metabolite Analysismentioning

confidence: 99%

“…Sex is known to influence the manifestation of many phenotypes in humans, including diseases [1][2][3]. Correspondingly, either sex stratification or sex adjustment is commonly advised in the epidemiological and molecular analysis of such traits [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Sex Dependency of Human Metabolic Profiles Revisited

Siegert¹

2012

Metabolomics

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“…Microarray studies of human tumor samples and bioinformatics meta-analyses continue to provide a wealth of information regarding genes differentially expressed in various types of cancer [12], [13], [14], [15], [16]. For liver cancer, more than 300 microarray studies have been published [17] identifying genes deregulated in HCC, although some of the published studies provide more transparent data than others.…”

Section: Introductionmentioning

confidence: 99%

Gene signatures in hepatocellular carcinoma (HCC)

Andrisani

Studach

Merle

2011

Seminars in Cancer Biology

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Primary hepatocellular carcinoma (HCC) is a significant human cancer globally, with poor prognosis. New and efficacious therapy strategies are needed as well as new biomarkers for early detection of at-risk patients. In this review, we discuss select microarray studies of human HCCs, and propose a gene signature that has promise for clinical/translational application. This gene signature combines the proliferation cluster of genes and the hepatic cancer initiating/stem cell gene cluster for identification of HCCs with poor prognosis. Evidence from cell-based assays identifies the existence of a mechanistic link between these two gene clusters, involving the proliferation cluster gene Polo-like kinase 1 (PLK1). We propose that PLK1 is a promising therapy target for HCC.

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“…For example, systemic lupus erythematosus (SLE), myasthenia gravis (MG), and rheumatoid arthritis (RA) are more common in women than men[36]. Gender specific differences in gene profiles of tumor samples from lung cancer patients have also been reported[37]. Also, IFN-γ secretion from mouse NKT cells is influenced by estradiol[38].…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Ex Vivo Functional Analysis of Human NKT Cells Reveals Production of MIP1-α and MIP1-β, a Lack of IL-17, and a Th1-Bias in Males

Snyder‐Cappione

Tincati²,

Eccles-James³

et al. 2010

PLoS ONE

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NKT cells contribute to the modulation of immune responses and are believed to be important in the pathogenesis of autoimmune and infectious diseases, as well as cancer. Variations in the composite NKT cytokine response may determine individual disease susceptibility or severity. Due to low frequencies in peripheral blood, knowledge of the breadth of ex vivo human NKT cell functions has been limited. To bridge this gap, we studied highly purified NKT cells from PBMC of healthy donors and assessed the production of 27 effector functions using sensitive Elispot and multiplex bead assays. We found the ex vivo human NKT cell response is predominantly comprised of the chemokines MIP1-α, and MIP1-β as well as the Th1 cytokines IFN-γ and TNF-α. Although lower in magnitude, there was also significant production of IL-2, IL-4, and perforin after mitogen stimulation. Surprisingly, little/no IL-5, IL-6, IL-10, or IL-13 was detected, and no subjects' NKT cells produced IL-17. Comparison of the NKT functional profiles between age-matched male and female subjects revealed similar IL-4 responses, but higher frequencies of cells producing IFN-γ and MIP1-α, from males. There were no gender differences in the circulating NKT subset distribution. These findings implicate chemokines as a major mechanism by which NKT cells control responses in humans. In addition, the panoply of Th2 and Th17 cytokine secretion by NKT cells from healthy donors may not be as pronounced as previously believed. NKT cells may therefore contribute to the gender bias found in many diseases.

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Age- and Sex-Specific Genomic Profiles in Non–Small Cell Lung Cancer

Abstract: Among a cohort of patients with NSCLC, subgroups defined by oncogenic pathway activation profiles were associated with recurrence-free survival. These findings require validation in independent patient data sets.

Cited by 57 publications

References 39 publications

Sex Dependency of Human Metabolic Profiles Revisited

Sex Dependency of Human Metabolic Profiles Revisited

Gene signatures in hepatocellular carcinoma (HCC)

A Comprehensive Ex Vivo Functional Analysis of Human NKT Cells Reveals Production of MIP1-α and MIP1-β, a Lack of IL-17, and a Th1-Bias in Males

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