Age and surgical outcome of low-grade glioma in Sweden

Corell, Alba; Carstam, Louise; Smits, Anja; Henriksson, Roger; Jakola, Asgeir Store

doi:10.1111/ane.12973

Cited by 29 publications

(18 citation statements)

References 51 publications

(86 reference statements)

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“…The clinical features of glioma are also important factors in uencing the prognosis of patients. We found that the risk score of older patients was higher than the youth, which means a worse prognosis in older patients, and the phenomenon was consistent with the existing research conclusions (32). Compared with the low-risk group, the high-risk group was mainly composed of GBM and lower-grade glioma (G2/G3) with poor prognosis.…”

Section: Discussionsupporting

confidence: 89%

Systematic analysis of 4-gene prognostic signature in patients with diffuse gliomas based on gene expression profiles

Huang

Xiong

Li³

2020

Preprint

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Background: Diffuse gliomas are a group of diseases that contain different degrees of malignancy and complex heterogeneity. Previous studies proposed biomarkers for certain grades of gliomas, but few of them have conducted a systematic analysis of different grades to search for molecular markers.Methods: WGCNA was used to find significant genes associated with malignant progression of diffuse glioma in TCGA glioma sequencing expression data and the GEO expression profile-merge meta dataset. Lasso regression was used for potential model building and the best model was selected by CPE, IDI and C_index. Risk score model was used to evaluate the gene signature prognostic power.Multi-omics data, including CNV, methylation, clinical traits and mutation, were used for model evaluation.Results: We find out 67 genes significantly associated with malignant progression of diffuse glioma by WGCNA. Next, we establish a new 4 gene molecular marker (KDELR2, EMP3, TIMP1, and TAGLN2).Multivariate cox analysis identified the risk score of the 4 genes as an independent predictor of prognosis in patients with diffuse gliomas, and its predictive power was independent of the histopathological grades of glioma. Further, we had confirmed in five independent test datasets and the risk score remained good predictive power. The combination of the prognosis model with specific molecular characteristics possessed better predictive power than risk score solely and we divided the low-risk group into three subtypes: LowRisk_IDH1wt, LowRisk_IDH1mut/ATRXmut, and LowRisk_IDH1mut/ATRXwt by combining IDH1 mutation with ATRX mutation, which possessed obvious survival difference. In further analysis, we found that the 4 gene prognosis model possessed multiomics features.Conclusion: we established a malignant-related 4-gene molecular marker by glioma expression profile data from multiple microarrays and sequencing data. The four markers had good predictive power on the overall survival of glioma patients and were associated with gliomas' clinical and genetic backgrounds, including clinical features, gene mutation, methylation, CNV, signal pathways.

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Section: Discussionsupporting

confidence: 89%

Systematic analysis of 4-gene prognostic signature in patients with diffuse gliomas based on gene expression profiles

Huang

Xiong

Li³

2020

Preprint

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“…In one study, age has been shown to be a risk factor for postoperative ND. 12 However, in our study, age was not seen as a significant factor affecting the NDs.…”

Section: Postoperative New Neurological Deficitscontrasting

confidence: 72%

Postoperative Neurological Complications after a Cranial Surgery: A Multicentre Prospective Observational Study

Venkatapura

Dubey

Panda

et al. 2020

Journal of Neuroanaesthesiology and Critical Care

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Background Cranial surgery is associated with multiple postoperative complications varying from simple nausea and vomiting to devastating complications such as stroke and death. This multicentre collaborative effort was envisioned to collect observational data regarding postoperative complications in cranial surgeries among the Indian population. The aim of this study was to describe the postoperative neurological complications occurring within the first 24 hours after surgery and to identify the predictive factors. Methods Data was collected from three participating tertiary care academic institutions. The study was prospective, observational, multicentre design with data collected over a period of two months or 100 cases, whichever is earlier, from each participating institute. A predesigned Microsoft excel sheet was distributed among all three centers to maintain uniformity. All patients aged 18 years and above of both sexes undergoing elective or emergency craniotomies were included in the study. The postoperative neurological complications (within 24 hours) assessed were: (1) Neurological deficit (ND) defined as new focal neurological motor deficit relative to preoperative status. (2) Sensorium deterioration (SD) defined as reduction in Glasgow coma score (GCS) by 2 or more points compared with preoperative GCS. (4) Postoperative seizures (SZs) defined as any seizure activity. All possible variables associated with the above neurological complications were tested using Chi-square/Fisher exact test or Mann–Whitney U test. The predictors, which were statistically significant at p < 0.2, were entered into a multiple logistic regression model. Alpha error of 5% was taken as significant. Results Data from three institutions was collected with a total of 279 cases. In total, there were 53 (19%) neurological complications. There were 28 patients with new postoperative NDs (10.04%), 24 patients had SD (8.6%), and 17 patients had seizures (6.1%). Neurological deficits were significantly less in institution 2. Diagnosis of traumatic brain injury (TBI) was associated with very low risk of ND, and vascular pathology was associated with higher chance of a ND. The duration of anesthesia was found to be significantly predictive of SD (OR/CI = 1.01 / 1–1.02). None of the factors were predictive of PS. Conclusion The incidences of postoperative ND, SD and postoperative seizures were 10%, 8.6%, and 6.1%, respectively. Studies with a much larger sample size are required for a better and detailed analysis of these complications.

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“…Patients with sGBM and new neurological impairments had worse OS than those without neurological de cits and primary low-grade glioma and GBM. [27] Our ndings indicated that new neurological impairments were a detrimental factor for the OS of patients with sGBM. In addition, for patients in group F, GTR and a consistent or increased postoperative KPS score were favorable independent factors for OS.…”

Section: The Value Of New Neurological Impairments In Patients With Sgbmmentioning

confidence: 66%

Clinical characteristics and survival outcomes of secondary glioblastoma

Sun¹,

Li²,

Wang³

et al. 2020

Preprint

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Background Secondary glioblastoma (sGBM) is a specific, and prognostic factors of sGBM are still unclear. This study retrospectively investigated clinical prognosis factors of survival outcomes of sGBM.Methods All of 125 patients were recruited in this study. Clinical characteristics and survival outcomes were acquired from inpatient records and follow-ups. Kaplan‑Meier survival analysis and Cox survival analysis were applied to identifying prognostic factors.Results The median overall survival (OS) were 301 days. Gross total resection (GTR) (HR = 0.613, 95% confident interval (CI) = 0.408-0.923, p = 0.019), diagnosed sGBM without newly occurring symptoms when regular re-examination (DR) (HR= 0.481, 95% CI = 0.308-0.750, p = 0.001), higher postoperative Karnofsky Performance Status (KPS) score (HR = 0.977, 95% CI = 0.961-0.993, p = 0.006) were independently favorable prognosis factors for OS. GTR was the favorable factor for OS of sGBM patients of DR (HR = 0.238, 95% CI = 0.100-0.570, p = 0.001) and with new functional impairments (HR = 0.410, 95% CI = 0.205-0.821, p = 0.012). Additionally, postoperative KPS score not decreasing was the favorable factor for OS of sGBM patients with new functional impairments (HR = 0.401, 95% CI = 0.202-0.795, p = 0.009) and with new occurring epilepsy (HR = 0.295, 95% CI from 0.092 to 0.950, p = 0.041).Conclusions For patients with sGBM, GTR, higher postoperative KPS score, and diagnosed without newly occurring symptoms were favorable factors for the OS. The GTR was recommended for sGBM patients to improve survival outcomes.

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Age and surgical outcome of low-grade glioma in Sweden

Cited by 29 publications

References 51 publications

Systematic analysis of 4-gene prognostic signature in patients with diffuse gliomas based on gene expression profiles

Systematic analysis of 4-gene prognostic signature in patients with diffuse gliomas based on gene expression profiles

Postoperative Neurological Complications after a Cranial Surgery: A Multicentre Prospective Observational Study

Clinical characteristics and survival outcomes of secondary glioblastoma

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