Age and the ovarian follicle pool assessed with transvaginal ultrasonography

Reuss, Mary Lynne; Kline, Jennie; Santos, R.; Levin, Bruce; Timor‐Tritsch, Ilan E.

doi:10.1016/s0002-9378(96)70439-8

Cited by 132 publications

(75 citation statements)

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“…The following quality characteristics of each study were registered: [1] sampling (consecutive vs. other), [2] data collection (prospective vs. retrospective), [3] study design (cohort study vs. case-control study), [4] blinding (present or absent), [5] selection bias, and [6] verification bias (9). The definition of poor response or pregnancy was documented, as well as whether an included study reported on only one cycle per couple or on multiple cycles.…”

Section: Search Strategymentioning

confidence: 99%

“…In the field of quantitative ultrasonography, achievements in the development of tests that assess ovarian reserve have also been reported. After the initial reports by Reuss et al (5) and Scheffer et al (6) that transvaginal ultrasonography could detect age-related decreases in follicle counts, Tomas et al (7) and Chang et al (8) introduced the antral follicle count (AFC) as an easy-to-perform and noninvasive method to provide essential information on ovarian responsiveness before initiation of gonadotropin stimulation in IVF.…”

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confidence: 99%

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Antral follicle count in the prediction of poor ovarian response and pregnancy after in vitro fertilization: A meta-analysis and comparison with basal follicle-stimulating hormone level

Hendriks

Mol

Bancsi

et al. 2005

Fertility and Sterility

344

191

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Result(s):We identified 11 studies on AFC and an updated total of 32 studies on basal FSH from the literature on the basis of preset criteria. The estimated summary receiver operating characteristic (ROC) curves showed AFC to perform well in the prediction of poor ovarian response. Also, prediction of poor ovarian response seemed to be more accurate with AFC compared with basal FSH. The estimated summary ROC curves for the prediction of nonpregnancy indicated a poor performance for both AFC and basal FSH. Conclusion(s):Transvaginal ultrasonography is an easy-to-perform and noninvasive method that provides essential predictive information on ovarian responsiveness. The predictive performance of AFC toward poor response is significantly better than that of basal FSH. Therefore, AFC might be considered the test of first choice in the assessment of ovarian reserve prior to IVF. (Fertil Steril 2005;83:291-301 Reproductive aging is associated with a reduction of the primordial follicle pool and loss of oocyte quality (1). The number of follicles leaving the pool of resting follicles to enter the growth phase toward the antral stages of development decreases with increasing age (2).In an IVF program, ovarian aging is characterized by decreased ovarian responsiveness to gonadotropin administration and lowered pregnancy rates. Correct identification of patients at risk of poor ovarian response by assessment of ovarian reserve before entering an IVF program is important.It can help physicians to tailor their advice to individual couples and help patients to decide whether to proceed with a costly and often demanding and disappointing IVF treatment.A recent meta-analysis on the performance of basal FSH level in the prediction of poor ovarian response and failure to become pregnant after IVF showed that a possible clinical application of basal FSH refers to only a minority of patients with extremely high basal FSH levels (3). However, to date basal FSH is still widely used in many fertility centers.Several other endocrine ovarian reserve tests have been proposed as predictors for IVF outcome in the past decade (4). In the field of quantitative ultrasonography, achievements in the development of tests that assess ovarian reserve have also been reported. After the initial reports by Reuss et al. (5) and Scheffer et al. (6) that transvaginal ultrasonography could detect age-related decreases in follicle counts,

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confidence: 99%

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confidence: 99%

Antral follicle count in the prediction of poor ovarian response and pregnancy after in vitro fertilization: A meta-analysis and comparison with basal follicle-stimulating hormone level

Hendriks

Mol

Bancsi

et al. 2005

Fertility and Sterility

344

191

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“…There is also evidence that a direct relation exists between decreased ovarian volume, antral follicle counts and diminished ovarian reserve (17,18). Previous studies have assessed the relations of basal FSH with ovarian antral follicle counts and ovarian volume as well as basal FSH with basal inhibin B to predict ovarian reserve (18)(19)(20)(21).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Basal and Clomiphene Citrate Induced FSH and Inhibin B, Ovarian Volume and Antral Follicle Counts as Ovarian Reserve Tests and Predictors of Poor Ovarian Response in IVF

Erdem

Gursoy

et al. 2004

J Assist Reprod Genet

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Purpose : To compare basal and clomiphene citrate (CC) induced follicle-stimulating hormone (FSH), estradiol (E 2 ), and inhibin B levels with ultrasound indices of ovarian reserve in infertile women and to test the prognostic value of these tests on response to ovarian stimulation in in vitro fertilization (IVF). Methods : Fifty-six patients had basal and CC induced serum hormone levels and ultrasound measured mean ovarian volume (MOV) and mean antral follicle counts (MFC). Thirty-two patients were then appropriately selected to have a total of 41 cycles of IVF/ICSI treatment. Results : Women with diminished ovarian reserve had lower MOV, MFC, day 3 and day 10 inhibin B levels ( p < 0.001). Only basal and CC induced FSH and inhibin B correlated with MOV and MFC. Poor responders in IVF/ICSI had higher basal FSH ( p < 0.05), lower basal and induced inhibin B levels ( p < 0.05), and lower MOV and MFC ( p < 0.01) than normal responders. Ovarian volume alone was better than age and basal hormones in predicting poor ovarian response, while abnormal CC test was the only independent significant factor in predicting ovarian response. However, age was the only independent predictor of pregnancy in IVF as compared to hormonal and ultrasound indices of ovarian reserve. Conclusion : CC test and ovarian volume are better than other hormonal and sonographic tests in predicting the response to ovarian stimulation in IVF cycles.

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“…Nivået av antimüllerhormon er i flere studier vist å ha en meget god korrelasjon til antallet antrale follikler som kan påvises ved ultralyd (24,26). Man vet fra tidligere at antallet antrale follikler er en god markør for det totale antallet follikler som er igjen i ovariene til enhver tid (27)(28)(29). …”

Section: Bedre Markør For Ovarial Responsunclassified

Antimüllerhormon ved behandling av ufrivillig barnløshet

Kalra¹

2009

Tidsskriftet

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SammendragBakgrunn. Kvinner i Norge, som i mange andre utviklede land, venter lenger i dag med å få barn enn før. Fruktbarheten hos kvinner synker med alderen, spesielt etter 35 års alder. Det har lenge vaert behov for en bedre markør av ovarial reserve og ovarial respons ved behandling av ufrivillig barnløshet. Denne artikkelen gir en oversikt over fysiologisk utvikling av follikler i eggstokkene og den spesielle plassen antimüllerhormon har i denne prosessen.Materiale og metode. Det ble gjort ikke-systematisk litteratursøk for relevante artikler i PubMed, Athens og Embase.Resultater. Nivået av antimüllerhor-mon er relativt stabilt gjennom menstruasjonssyklusen, og hormonet synes å vaere en pålitelig markør for ovarial respons. Bestemmelse av hormonnivået vil kunne identifisere kvinner med høy risiko for avvikende respons ved ovarial stimulering.Fortolkning. Klinisk bruk av antimül-lerhormon er først og fremst aktuelt ved utredning og behandling av ufrivillig barnløshet.

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Age and the ovarian follicle pool assessed with transvaginal ultrasonography

Cited by 132 publications

References 9 publications

Antral follicle count in the prediction of poor ovarian response and pregnancy after in vitro fertilization: A meta-analysis and comparison with basal follicle-stimulating hormone level

Antral follicle count in the prediction of poor ovarian response and pregnancy after in vitro fertilization: A meta-analysis and comparison with basal follicle-stimulating hormone level

Comparison of Basal and Clomiphene Citrate Induced FSH and Inhibin B, Ovarian Volume and Antral Follicle Counts as Ovarian Reserve Tests and Predictors of Poor Ovarian Response in IVF

Antimüllerhormon ved behandling av ufrivillig barnløshet

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