2012
DOI: 10.1016/j.mad.2012.08.001
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Age-associated alterations in retinal arteriole reactivity to endothelin-1 differ between the sexes

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Cited by 9 publications
(7 citation statements)
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“…In the cerebrovasculature, sex differences have been described with respect to vascular anatomy [21] and also pharmacology [60]. In the brain, arteriolar responses to vasoactive compounds, including angiotensin [19, 114] and endothelin-1 [29, 71], and nitric oxide synthase activity [88, 115], are sexually dimorphic.…”
Section: Vascular Reactivity (Vsm Dilation/constriction)mentioning
confidence: 99%
See 1 more Smart Citation
“…In the cerebrovasculature, sex differences have been described with respect to vascular anatomy [21] and also pharmacology [60]. In the brain, arteriolar responses to vasoactive compounds, including angiotensin [19, 114] and endothelin-1 [29, 71], and nitric oxide synthase activity [88, 115], are sexually dimorphic.…”
Section: Vascular Reactivity (Vsm Dilation/constriction)mentioning
confidence: 99%
“…As females age, coronary arteriolar constriction to ET-1 increases, while in males with aging reduction in the constrictor response to ET-1 is observed [66]. In retinal arterioles, ET-1 sensitivity declines with age, especially in females, while expression levels of the two receptors, ETA and ETB, displayed no differences with either age or sex [71]. It was determined using a pharmacological approach that the age-related reduction in ET-1 response in males was mediated by ETA signaling pathways, while in females it was the ETB signaling pathways that mediated the attenuated ET-1 contractility with age.…”
Section: Vascular Reactivity (Vsm Dilation/constriction)mentioning
confidence: 99%
“…The sensitivity of ET A receptors to endothelin‐1 is much stronger in men than in women, which may explain the observed sex difference in the association between OSA and retinal arteriolar narrowing. Additionally, an animal study suggested that the sensitivity to endothelin‐1 may decline with age, especially in females . On the other hand, men but not women with severe OSA have been reported with higher risk of cardiac remodeling such as congestive heart failure, which elevates pulmonary wedge pressure and may affect retinal venular widening …”
Section: Discussionmentioning
confidence: 99%
“…Additionally, an animal study suggested that the sensitivity to endothelin-1 may decline with age, especially in females. 44 On the other hand, men but not women with severe OSA have been reported with higher risk of cardiac remodeling such as congestive heart failure, which elevates pulmonary wedge pressure and may affect retinal venular widening. 23 Systemic inflammation and hyperglycemia, which are related to severe OSA, may cause diabetic retinopathy.…”
Section: Discussionmentioning
confidence: 99%
“…These findings could be due to the heterogeneity observed in the microcirculation in vivo , where several physiological mechanisms are involved simultaneously and may reveal different results. Additionally, there are controversial studies concerning the action of endothelin-1, with some researchers observing reduced vasoconstriction in males (30) and other researchers observing it in females (32). In our study, the vasoconstriction elicited by endothelin-1 was not significantly different between males and females.…”
Section: Discussionmentioning
confidence: 99%