Age-associated prognosis following curative resection for colorectal cancer

BackgroundSerum carcinoembryonic antigen (sCEA) level might be an indicator of disease. Indeed, an elevated sCEA level is a prognostic factor in colorectal cancer (CRC) patients. However, the genetic determinants of sCEA level in healthy and CRC population remains unclear. Thus we investigated the genetic markers associated with elevated serum sCEA level in these two populations and its clinical implications.Methods and FindingsGenome-wide association study (GWAS) was conducted in a cohort study with 4,346 healthy male adults using the Illumina Omni 1 M chip. Candidate SNPs associated with elevated sCEA levels were validated in 194 CRC patients on ABI Taqman platform. Eight candidate SNPs were validated in CRC patients. The rs1047781 (chr19- FUT2) (A/T) was associated with elevated sCEA levels, and rs8176746 (chr9- ABO) was associated with the regional lymph metastasis in the CRC patients. The preoperative sCEA level was a risk factor for tumor recurrence in 5 years after operation (OR = 1.427, 95% CI: 1.005∼1.843, P = 0.006). It was also one of the risk factors for regional lymph node metastasis (OR = 2.266, 95% CI: 1.196∼4.293, P = 0.012). The sCEA level in rs1047781-T carriers was higher than that in the A carriers in CRC patients without lymph node metastasis (P = 0.006). The regional lymph node metastasis in patients with homozygote AA of rs8176746 was more common than that in the heterozygote AG carriers (P = 0.022). In addition, rs1047781-AT and TT CRC patients exhibited a worse disease-free survival than AA genotype carriers (P = 0.023).ConclusionsWe found candidate SNPs associated with elevated sCEA levels in both healthy males and CRC population. Rs1047781 (chr19- FUT2) may be the susceptible locus for recurrence of CRC in a population from Southern China.

show abstract

“…was also worse than the younger (25∼75 yrs) [46]. However, we did not find this association in our population.…”

Section: Discussioncontrasting

confidence: 82%

Genetic Variations Affecting Serum Carcinoembryonic Antigen Levels and Status of Regional Lymph Nodes in Patients with Sporadic Colorectal Cancer from Southern China

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Köhler and his friends reported that there was no significant difference between the survival times of the young group and the older individuals. Common belief is that CRC is more aggressive in younger individuals [8,9]. Dukes and Bussey reported that most of the old CRC patients do not represent an aggressive nature.…”

Section: Discussionmentioning

confidence: 97%

Negative prognostic factors in colorectal carcinoma: An analysis of 448 patients

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Colonic anastomotic dehiscence is a much feared complication in the immediate postoperative period of colonic resections. Such leakages significantly increase the rates of morbidity and mortality after large bowel resections [25]. The rates of dehiscence in experimental studies on animal models vary between 3% and 30% [25][26][27][28].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Irinotecan on the Healing of Colonic Anastomoses in Rats

Pramateftakis¹,

Kanellos²,

Demetriades³

et al. 2007

TOSJ

View full text Add to dashboard Cite

Aim: The aim of this experimental study was to investigate the effects of intraperitoneally injected irinotecan on the healing of colonic anastomoses after colon resection.Methods: Thirty male Wistar rats were used. The rats were randomized into two groups of 15 rats each. Immediately after colonic anastomoses were performed, the rats were injected intraperitoneally with either 3 ml of 0.9% NaCl solution or irinotecan (3 mg/kg body weight) depending on their group. All rats were sacrificed on the eighth postoperative day. The anastomoses were examined macroscopically and histologically. The anastomotic bursting pressures were recorded.Results: Anastomotic dehiscence was noted in 3 rats of the irinotecan group. All anastomoses of the control group remained intact until sacrifice. The adhesion formation at the anastomotic sites and the average inflammatory cell infiltration scores were significantly higher in the irinotecan group compared to the control group. The bursting pressures, the hydroxyproline tissue content, the fibroblast activity and the collagen deposition were significantly lower in the irinotecan group. Neoangiogenesis did not differ significantly between the groups.Conclusion: Irinotecan, when injected intraperitoneally, affects the healing of colonic anastomoses in rats.

show abstract

Age-associated prognosis following curative resection for colorectal cancer

Abstract: This aged-grouped study indicates that prognosis is comparable between younger and middle-aged patients whereas in elderly patients it is worsening but not statistically significantly.

Cited by 12 publications

References 2 publications

Genetic Variations Affecting Serum Carcinoembryonic Antigen Levels and Status of Regional Lymph Nodes in Patients with Sporadic Colorectal Cancer from Southern China

Genetic Variations Affecting Serum Carcinoembryonic Antigen Levels and Status of Regional Lymph Nodes in Patients with Sporadic Colorectal Cancer from Southern China

Negative prognostic factors in colorectal carcinoma: An analysis of 448 patients

The Effects of Irinotecan on the Healing of Colonic Anastomoses in Rats

Contact Info

Product

Resources

About