Age-Associated Reduction in Nocturnal Pineal Melatonin Levels in Female Rats1

Reíter, Russel J.; Craft, Cheryl M.; Johnson, John E.; King, Thomas S.; Richardson, Bruce A.; Vaughan, George M.; Vaughan, Mary K.

doi:10.1210/endo-109-4-1295

Cited by 217 publications

(122 citation statements)

References 10 publications

Supporting

Mentioning

105

Contrasting

Unclassified

Order By: Relevance

“…), sex and light regimen have to be considered, too. The pineal MEL levels in middle-aged female rats (12-month-old) range between levels of young adult and old rats (Reiter et al 1981), whereas in the male rats of the same age a loss of night MEL plasma peak was found (Rasmussen et al 2001).…”

Section: Discussionmentioning

confidence: 95%

Effect of Prolonged Melatonin Application on Metabolic Parameters and Organ Weights in Young Male and Female Sprague-Dawley rats

Marková¹,

Adámeková²,

Kubatka³

et al. 2003

Acta Vet. Brno

View full text Add to dashboard Cite

Marková M., E. Adámeková, P. Kubatka, B. Bojková, E. Ahlersová, I. Ahlers: Effect of Prolonged Melatonin Administration on Metabolic Parameters and Organ Weights inYoung Male and Female Sprague-Dawley rats. Acta Vet. Brno 2003, 72: 163-173.The question of the introduction of melatonin as a drug remains still open. Especially the long term melatonin administration have to be analysed and discussed. The aim of present study was to analyze the effect of low doses of melatonin (4 µg/ml of tap water) administered for 70 days, daily from 15.00 to 08.00 h (from 08.00 to15.00 h animals were drinking tap water) on selected metabolic parameters in male and female Sprague-Dawley rats. In addition to concentration/content of triacylglycerols, phospholipids, cholesterol, malondialdehyde, glucose and glycogen in the serum and tissues, serum corticosterone and insulin, weights of selected organs, periovarial and epididymal fat and body weight were recordered. Melatonin was not administered to control groups. Oral glucose tolerance tests were carried out before melatonin administration and 9 weeks thereafter.Male and female rats aged 5 weeks were adapted to standard vivarium conditions and artificial light regimen L:D-12:12 h. The animals were fed MP diet containing 2.5 % fat at least and drank tap water or melatonin solution ad libitum. The rats were weighed twice a week and food and water intake was recorded. After 10 weeks they were sacrificed, organs and tissues were weighed and the aforementioned metabolic parameters were determined in the serum, liver, heart muscle and bone marrow (femur).Melatonin administration decreased significantly the serum triacylglycerol concentration and liver glycogen content in male rats, and it increased liver the phospholipid content in females. Melatonin did not acutely modify the values of other metabolic parameters. Prolonged melatonin administration significantly increased the weight of heart muscle and periovarial fat in females, in males significantly reduced the weight of adrenals, liver, heart muscle and epididymal fat as well as their body weight from day 19 to the end of experiment. Body weight in MEL-drinking females was similar to that in controls. Water and food intake in MEL-drinking males did not differ from controls, in females was temporarily increased in week 6.Prolonged melatonin administration did not significantly influence the glycemia level. The oral glucose tolerance test curves were normal before melatonin administration; one abnormal curve (out of 9 individuals) in the female group and 2 abnormal curves in the male group (out of 9 individuals) were recorded 9 weeks after melatonin administration. Prolonged melatonin treatment resulted in sexual differences in body weight, epididymal and periovarial fat, and heart muscle weight. Melatonin, metabolic and hormone responses, body and organ weightsAlthough pineal gland is the main site of melatonin (MEL) synthesis in mammals its synthesis has been proved in the retina, extraorbital lacrimal glands, Harder's glands...

show abstract

Section: Discussionmentioning

confidence: 95%

Effect of Prolonged Melatonin Application on Metabolic Parameters and Organ Weights in Young Male and Female Sprague-Dawley rats

Marková¹,

Adámeková²,

Kubatka³

et al. 2003

Acta Vet. Brno

View full text Add to dashboard Cite

show abstract

“…Other groups have also confirmed that oestrogen treatments were able to enhance neurogenesis in the dentate gyrus of the hippocampus in adult animals (Brinton 2009;Pawluski et al 2009). Reiter et al (1981) reported a marked decline in nocturnal pineal melatonin levels with ageing in female rats. Okatani et al (2000) observed that although nocturnal serum melatonin levels in premenopausal women declined moderately from 17 to 45 years of age, it showed an increase during the period from 46 to 50 years of age.…”

mentioning

confidence: 99%

Melatonin and oestrogen treatments were able to improve neuroinflammation and apoptotic processes in dentate gyrus of old ovariectomized female rats

Kireev

Vara

Viña

et al. 2014

AGE

View full text Add to dashboard Cite

The aim of this study was to determine the outcomes of oestrogen and melatonin treatments following long-term ovarian hormone depletion on neuroinflammation and apoptotic processes in dentate gyrus of hippocampi. Forty-six female Wistar rats of 22 months of age were used. Twelve of them remained intact, and the other 34 were ovariectomized at 12 months of age. Ovariectomized animals were divided into three groups and treated for 10 weeks with oestrogens, melatonin or saline. All rats were killed by decapitation at 24 months of age, and dentate gyri were collected. A group of 2 month-old intact female rats was used as young control. The levels of pro-inflammatory cytokines and heat shock protein 70 (HSP 70) were analysed by ELISA. The expressions of TNFα, IL1β, GFAP, nNOS, iNOS, HO-1, NFκB, Bax, Bad, AIF, Bcl2 and SIRT1 genes were detected by real-time (RT)-PCR. Western blots were used to measure the protein expression of NFκB p65, NFκB p50/105, IκBα, IκBβ, p38 MAPK, MAP-2 and synapsin I. We have assessed the ability of 17β-oestradiol and melatonin administration to downregulate markers of neuroinflammation in the dentate gyrus of ovariectomized female rats. Results indicated that 17β-oestradiol and melatonin treatments were able to significantly decrease expression of pro-inflammatory cytokines, iNOS and HO-1 in the hippocampus when compared to non-treated animals. A similar age-and long-term ovarian hormone depletion-related increase in GFAP was also attenuated after both melatonin and oestradiol treatments. In a similar way to oestradiol, melatonin decreased the activation of p38 MAPK and NFκB pathways. The treatments enhanced the levels of synaptic molecules synapsin I and MAP-2 and have been shown to modulate the pro-antiapoptotic ratio favouring the second and to increase SIRT1 expression. These findings support the potential therapeutic role of melatonin and oestradiol as protective antiinflammatory agents for the central nervous system during menopause.

show abstract

“…The amount of melatonin and its main urinary metabolite, 6-sulphatoxymelatonin decreases with the advancing age [14,15]. In humans, melatonin production not only diminishes with age, but it is also significantly lower in many age-related diseases such as cardiovascular disease [16,17].…”

Section: Discussionmentioning

confidence: 99%

Association of Endogenous Melatonin with Uric Acid and Traditional Cardiovascular Risk Factors in Healthy Young Male

Yıldız¹,

Şahin²,

Aladağ³

et al. 2015

Adv Clin Exp Med

View full text Add to dashboard Cite

Background. Uric acid may act as an antioxidant; high serum uric acid levels are often associated with cardiovascular disease, such as coronary artery disease. Melatonin plays a role as a direct free radical scavenger and indirect antioxidant. No study has examined the relationships between endogenous melatonin and uric acid in order to predict the risk of future cardiovascular disease in male so far. To better characterize a possible relationship, we studied the association of endogenous melatonin with uric acid and traditional cardiovascular risk factors such as plasma lipids, and glucose in healthy young male. Material and Methods. Twenty-one male participants [mean age: 22.6 2.5 (18-26) year], non-smoking; their medication or alcohol consumption history were studied. Blood samples for measuring melatonin concentrations were collected in the supine position between 13:30-14:30 hours. After centrifugation, plasma samples were immediately frozen at -20°C until analysis. Results. Although we found a significant negative correlation between the levels of endogeneous melatonin and uric acid (p = 0.01, r = -0.51), we did not find any correlation among the melatonin and other antropometric, hemodynamic and biochemical parameters in male subjects (p > 0.41).Conclusions. The present study demonstrated that a significant negative correlation between the levels of endogeneous melatonin and uric acid in healthy young male (Adv Clin Exp Med 2015, 24, 2, 233-237).

show abstract

Age-Associated Reduction in Nocturnal Pineal Melatonin Levels in Female Rats1

Cited by 217 publications

References 10 publications

Effect of Prolonged Melatonin Application on Metabolic Parameters and Organ Weights in Young Male and Female Sprague-Dawley rats

Effect of Prolonged Melatonin Application on Metabolic Parameters and Organ Weights in Young Male and Female Sprague-Dawley rats

Melatonin and oestrogen treatments were able to improve neuroinflammation and apoptotic processes in dentate gyrus of old ovariectomized female rats

Association of Endogenous Melatonin with Uric Acid and Traditional Cardiovascular Risk Factors in Healthy Young Male

Contact Info

Product

Resources

About