Age at first febrile seizure correlates with perinatal maternal emotional symptoms

Thébault-Dagher, Fanny; Herba, Catherine M.; Séguin, Jean R.; Muckle, Gina; Lupien, Sonia J.; Carmant, Lionel; Simard, Marie-Noëlle; Shapiro, Gabriel D.; Fraser, William D.; Lippé, Sarah

doi:10.1016/j.eplepsyres.2017.06.001

Cited by 10 publications

(22 citation statements)

References 45 publications

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“… 25 , 60 Prenatal or perinatal stress can have programming effects on the developing brain that enhance neuronal excitability resulting in lower seizure threshold. 61 , 62 Residential exposure to traffic noise and air pollution are other risk factors. 63 …”

Section: Etiology and Pathogenesismentioning

confidence: 99%

Febrile seizures: an overview

Leung¹,

Hon²,

Leung³

2018

DIC

190

186

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BackgroundFebrile seizures are the most common neurologic disorder in childhood. Physicians should be familiar with the proper evaluation and management of this common condition.ObjectiveTo provide an update on the current understanding, evaluation, and management of febrile seizures.MethodsA PubMed search was completed in Clinical Queries using the key terms ‘febrile convulsions’ and ‘febrile seizures’. The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews.ResultsFebrile seizures, with a peak incidence between 12 and 18 months of age, likely result from a vulnerability of the developing central nervous system to the effects of fever, in combination with an underlying genetic predisposition and environmental factors. The majority of febrile seizures occur within 24 hours of the onset of the fever. Febrile seizures can be simple or complex. Clinical judgment based on variable presentations must direct the diagnostic studies which are usually not necessary in the majority of cases. A lumbar puncture should be considered in children younger than 12 months of age or with suspected meningitis. Children with complex febrile seizures are at risk of subsequent epilepsy. Approximately 30–40% of children with a febrile seizure will have a recurrence during early childhood. The prognosis is favorable as the condition is usually benign and self-limiting. Intervention to stop the seizure often is unnecessary.ConclusionContinuous preventative antiepileptic therapy for the prevention of recurrent febrile seizures is not recommended. The use of intermittent anticonvulsant therapy is not routinely indicated. Antipyretics have no role in the prevention of febrile seizures.

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Section: Etiology and Pathogenesismentioning

confidence: 99%

Febrile seizures: an overview

Leung¹,

Hon²,

Leung³

2018

DIC

190

186

View full text Add to dashboard Cite

show abstract

“…Perinatal stress and exposure to nicotine and/or alcohol may potentiate FS due to increase in cortisol level in the offspring. [48][49][50] Approximately 80% of cases of FS are related with viral infection and the most frequent infections are middle ear infections, tonsillitis, sinusitis, pneumonia, bronchiolitis, tooth infections, and gastroenteritis. [51][52][53] Although vaccine is generally well-tolerated, transient adverse events such as FS are rarely experienced after vaccination.…”

Section: Etiology and Pathogenesismentioning

confidence: 99%

“…[5] Box 1: Cause and factors associated with febrile seizures. [35,[48][49][50][51][52][53] Familial: Genetics [ [80,100] 1. Open the airway, aspirate secretions, maintain adequate ventilation, and ensure perfusion 2.…”

Section: Prevention Of Further Attackmentioning

confidence: 99%

Clinical review of febrile seizure and updates

Hossain

Saha

2021

KPJ

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Febrile seizure (FS) is one of the most common seizures seen in infant and pre-school age. There are two types of FSs, simple and complex. Simple FS are commonly benign, but complex FS have long-term effects. Most children with FS have normal growth and development after the attack; however, recent evidences suggest that a small group of children presenting fever with seizure may subsequently develop epilepsy or recurrent seizures. Diagnosis is mainly based on clinical presentation, electroencephalogram, lumbar puncture, and neuroimaging, which can be applied based on clinical scenario, but not routinely. Treatment is principally acute management of seizure along with address of underlying etiology and intermediate prophylaxis for preventing further attack. Pediatrician should be familiar with the proper diagnosis and management of this condition. This review will highlight an update on the current diagnostic and management issues of FS.

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“…Notably, associations between maternal prenatal stress (MPS) and FS have been shown in animal 2 and human studies. 3,4 Animal models have indicated several mechanisms to be responsible for this link, such as altered neurogenesis and long-term changes in stress hormones levels, which have a known excitatory effect. 2 In humans, self-reported MPS has been associated with increased FS severity and younger age at first occurrence.…”

Section: Introductionmentioning

confidence: 99%

Febrile seizure incidence and age at first occurrence are associated with changes in placental normalized gene expression: the ‘3D’ pregnancy cohort study

Thébault-Dagher

Robles

Herba

et al. 2021

J Neuroendocrinology

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Self‐reported maternal prenatal stress (MPS) has been associated with earlier febrile seizure (FS) age of onset in offspring. Studies are needed to understand how the biological systems associated with exposure to psychological MPS are linked to seizure disorders in children. The present study aimed to investigate whether placental markers of MPS are linked to FS incidence and age at first occurrence. A subsample of children with FS (n = 28) and matched controls (n = 84), were drawn from the longitudinal 3D pregnancy cohort (N = 2366 mother–child dyads). Expression of placental genes associated with glucocorticoids, serotonin and fetal/placental growth were analysed from placental tissues, compared between groups and associated with age at first FS. Overall placental normalized gene expression was statistically different (p < .001). Children with FS showed overexpression of the serotonin transporter (mean difference = 0.61, 95% confidence interval [CI] = 0.9–1.13), connexin 43 (mean difference = 0.69, 95% CI = 0.30–1.09), zonula occludens‐1 (mean difference = 0.84, 95% CI = 0.42–1.26) and underexpression of glucocorticoid receptor β (mean difference = 0.84, 95% CI = −1.49 to 0.19) and serotonin receptor 2B (mean difference = 1.57, 95% CI = −2.35 to 0.78) compared to controls. Increased expression of the serotonin transporter predicted 37.2% in variation of age at first FS. The correlation matrix showed pregnancy‐specific anxiety during the second trimester was moderately associated with age at first FS (r = −0.38) but was not a significant predictor in the regression model. Although our current results do not display a significant effect of self‐reported MPS on FS, the present study is the first to show that placental gene biomarkers usually known to be associated with MPS display different expressions in children with FS. Specifically, our results suggest that placental genes associated with the glucocorticoid, serotonergic and fetal/placental growth systems may be candidate mechanisms leading to increased vulnerability offspring in FS. Because self‐reported MPS was not found as a significant predictor in our statistical models, future studies are needed to investigate the mechanisms causing the observed changes in placental genes and their association with seizure disorders.

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Age at first febrile seizure correlates with perinatal maternal emotional symptoms

Cited by 10 publications

References 45 publications

Febrile seizures: an overview

Febrile seizures: an overview

Clinical review of febrile seizure and updates

Febrile seizure incidence and age at first occurrence are associated with changes in placental normalized gene expression: the ‘3D’ pregnancy cohort study

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