Age at menarche and age at natural menopause as predictors of glycemic control in type 2 diabetic patients

Shen, Chong; Wen, Jinbo; Pan, Xiaoqun; Su, Jian; Du, Wei‐Dong; Pan, Enchun; Zhang, Qin; Zhang, Ning; Sheng, Hongyan; Liu, Chunlan; Wang, Hui; Wu, Ming; Qin, Yu

doi:10.1016/j.jdiacomp.2018.04.012

Cited by 12 publications

(14 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study by Shen et al indicated that Chinese women with T2DM with early and late menopause had worse glycemic control. 15 We found no direct correlation between age at the onset of menopause and overall glycemic control, but women who were diagnosed with diabetes before menopause had higher overall HbA1c, although there were no differences between BMIs. This may imply that poorer glycemic control was not mediated by body adiposity, and other factors may have a role.…”

Section: Discussioncontrasting

confidence: 65%

“…Contrary to our findings, a large study from China has indicated that early age at menarche was associated with worse metabolic control (HbA1c >7%). 15 However, the thresholds for menarche age used to separate the subgroups in that study were different (<15 years old, 15-18 years old, and >18 years old, respectively). 15 Moreover, the mean HbA1c in these subgroups were similar (p = 0.37), which is in concordance with our study.…”

Section: Discussionmentioning

confidence: 88%

See 1 more Smart Citation

Reproductive Health and Metabolic Parameters in Women with Type 2 Diabetes

Onea¹,

Máté

2020

Journal of Interdisciplinary Medicine

View full text Add to dashboard Cite

Aim: This study evaluated the correlations between metabolic parameters and reproductive health data in women with type 2 diabetes mellitus (T2DM).Material and methods: In this observational retrospective study, data from the medical records of 324 adult women with T2DM attending their regular diabetes check-ups were collected and analyzed (i.e., anthropometric parameters at first outpatient visit and yearly thereafter, first recorded HbA1c and all HbA1c for the entire follow-up duration, as well as obstetrical/gynecological information).Results: Age at the diagnosis of T2DM correlated positively with age at menarche (r = 0.21, [95% CI: 0.09, 0.31], p = 0.0002) and age at menopause (r = 0.18 [95% CI: 0.07, 0.29], p <0.01). Age at menarche correlated negatively with mean weight (r = –0.21 [95% CI: –0.31, –0.10], p: 0.0002) and mean BMI (–0.22 [–0.32, –0.11], p <0.0001) over the follow-up time. Patients with shorter time difference between age at menarche and age at onset of T2DM (≤45 years) had higher mean weight (83.8 ± 14.5 kg vs. 78.4 ± 16.0 kg, p = 0.0001), BMI (33.2 ± 5.6 kg/m2 vs. 31.8 ± 5.7 kg/m2, p <0.05), and HbA1c over time (6.9 ± 0.8% vs. 6.6 ± 0.9%, p <0.0001). Women with T2DM with earlier menarche (<12 years old), with irregular menses during their reproductive life, and ≥3 pregnancies had higher overall BMI, but mean HbA1c were not significantly different. However, women diagnosed with T2DM before menopause had a higher mean HbA1c over time (7.1 ± 0.8% vs. 6.7 ± 0.9%, p <0.01).Conclusion: The BMI correlated with several indicators of reproductive health (earlier menarche, irregular menses, and higher number of pregnancies), while earlier onset of T2DM influenced metabolic control in women with T2DM.

show abstract

Section: Discussioncontrasting

confidence: 65%

Section: Discussionmentioning

confidence: 88%

Reproductive Health and Metabolic Parameters in Women with Type 2 Diabetes

Onea¹,

Máté

2020

Journal of Interdisciplinary Medicine

View full text Add to dashboard Cite

show abstract

“…Whether menopausal status is associated with T2DM independently of age and other confounding factors remains controversial [16][17][18]. A Dutch study found that postmenopausal women had a higher risk of T2DM, even after adjustments for important covariates Prevalence ratios (solid line) and 95% confidence intervals (dashed lines) of the reproductive period for type 2 diabetes mellitus (T2DM) (reference: 17 years).…”

Section: Discussionmentioning

confidence: 99%

Association between Reproductive Factors and Type 2 Diabetes: A Cross-Sectional Study

Li²,

Jiang

et al. 2022

IJERPH

View full text Add to dashboard Cite

(1) Introduction: The available studies on the association between type 2 diabetes mellitus (T2DM) and menopause report conflicting results. (2) Objective: This study aimed to investigate the association of menopausal status, age at menopause, and length of the reproductive period with T2DM. (3) Methods: This cross-sectional study is part of the ‘China Eastern Cohort Study’, which is a community-based cohort study. Multistage, stratified, clustered sampling was used to recruit the study participants in Shanghai, China. Age at menarche and menopause was recorded, and reproductive period was calculated. Weighted logistic regression was used to calculate the prevalence ratios (PRs) with 95% confidence intervals (CIs) of T2DM. Restricted cubic splines were used to assess the relationship between age at menopause, reproductive period, and T2DM. (4) Results: A total of 20,128 women were included. The prevalence of T2DM was 13.7%. Postmenopausal women exhibited a higher prevalence of T2DM than premenopausal women (p < 0.001) and an unfavorable metabolic profile, including higher body mass index, hypertension, and hyperlipidemia. A higher risk of T2DM was observed in postmenopausal women (PR2.12, 95%CI: 1.79-2.51, p < 0.001) compared with premenopausal women, independently of confounding factors. After adjustment for confounding factors, age at menopause and reproductive period were not significantly associated with T2DM. (5) Conclusions: Postmenopausal status is associated with T2DM, while menopausal age and reproductive period are not associated with T2DM. Menopausal status should be considered during T2DM screening.

show abstract

“…These studies have reported significant results, which are consistent with our findings. Shen et al also indicate that postmenopausal women show significant association with worse glycemic control, including FPG levels, which is independently associated with 10-year cardiovascular risk [36, 37]. Additionally, diabetes is associated with chronic inflammation, which is characterized by the release of excess pro-inflammatory cytokines, abrupt levels of acute-phase proteins, and other mediators, which are integral to the severity of cardiovascular disorders [38–40].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of cardiovascular risk factors in non-menopausal and postmenopausal inpatients with type 2 diabetes mellitus in China

Zhou

Zhang

et al. 2019

BMC Endocr Disord

View full text Add to dashboard Cite

Background To investigate the prevalence of cardiovascular disease (CVD) risk factors and assess the 10-year risk of CVD in non-menopausal and postmenopausal women with type 2 diabetes mellitus (T2DM). Methods A total of 569 patients with T2DM at a Chinese tertiary hospital were investigated using the Framingham Risk Score (FRS). We evaluated the 10-year risk of CVD, clinical and menopause characteristics in all subjects. Results Among the 569 diabetic patients, the incidence of smoking, dyslipidemia, hypertension, overweight or obesity, and nonalcoholic fatty liver disease (NAFLD) was 0.7, 36.2, 38.1 56.6 and 58.2%, respectively. The usage rate of hypoglycemic agents, antihypertensive agents, lipid modulators and antithrombotic drugs was 88.6, 78.3, 50.0 and 27.1%, respectively. However, only 1.2% of inpatients achieved the three target goals for the control of blood glucose (HbA1c < 7%), blood pressure (systolic blood pressure < 130 mmHg, diastolic blood pressure < 80 mmHg), and blood lipids (total cholesterol < 174 mg/dL). The 10-year risk of CVD was (1.6 ± 1.5%) and tended to increase along with age (F = 27.726, P < 0.001). For all subjects (n = 569), multiple linear regression analysis showed that menopause (β = 0.275, P < 0.001), low-density lipoprotein cholesterol (LDL-C) (β = 0.212, P < 0.001), fasting plasma glucose (FPG) (β = 0.093, P = 0.018) and waist-to-hip-ratio (β = − 0.078, P = 0.047) were risk factors of 10-year risk of CVD, which may explain the variance of 14.3%. In the postmenopausal group (n = 397), LDL-C (β = 0.227, P < 0.001), FPG (β = 0.139, P = 0.003) and time since menopause (β = 0.230, P < 0.001) were found to be associated with CVD, which may explain the variance of 14.6%. Conclusion The incidence of dyslipidmia, hypertension, overweight or obesity and NAFLD is high. The level of control of blood glucose, blood pressure, and blood lipids was found to be extremely low and the treatment status was not ideal. Besides menopause, LDL-C, FPG and time since menopause were found to be independent risk factors for the 10-year risk of CVD. Therefore, it is necessary to focus on comprehensive control of multiple risk factors, such as plasma glucose, blood pressure and serum lipid.

show abstract

Age at menarche and age at natural menopause as predictors of glycemic control in type 2 diabetic patients

Cited by 12 publications

References 36 publications

Reproductive Health and Metabolic Parameters in Women with Type 2 Diabetes

Reproductive Health and Metabolic Parameters in Women with Type 2 Diabetes

Association between Reproductive Factors and Type 2 Diabetes: A Cross-Sectional Study

Prevalence of cardiovascular risk factors in non-menopausal and postmenopausal inpatients with type 2 diabetes mellitus in China

Contact Info

Product

Resources

About