Age at menarche and menopause of uterine cancer patients

Graaff, J. de; Stolte, L.A.M.

doi:10.1016/0028-2243(78)90014-x

Cited by 21 publications

(11 citation statements)

References 5 publications

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“…In contrast, later menopause has been related to increased risk of breast cancer, 13,14 endometrial and ovarian cancer. 15,16 We analyzed cause specific mortality, but no significant relationship was seen in any category. That was because the number of deaths in our analysis was too small to draw firm conclusions about specific causes of death.…”

Section: Femalesmentioning

confidence: 99%

“…[6][7][8][9] However, randomized controlled trials [10][11][12] did not show the effect of HRT on cardiovascular disease outcome. On the other hand, some epidemiologic studies reported that later menopause increased the risk of breast cancer 13,14 and endometrial and ovarian cancer, 15,16 and many studies reported that HRT also increased the risk of breast cancer. 12,17 There were some studies examining the relationship between age at menopause and all-cause mortality.…”

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confidence: 99%

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Age at Menopause and Mortality in Japan: the Jichi Medical School Cohort Study

Amagai

Ishikawa

Gotoh

et al. 2006

Journal of Epidemiology

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Communications. The people who moved out of the communities during the observation period were followed up until the date of the emigration. Data on emigration of the study subjects were obtained every year from their municipal governments.Age at menopause was categorized into <40 years, 40-44 years, 45-49 years, 50-54 years, and 55+ years. The reference group was females who were 45-49 years at menopause.Statistical analysis was performed using the SPSS ® software version 11.0. Descriptive parameters are shown as mean, standard deviation or proportion (%). We compared characteristics between the groups by one-way analyses of variance or the chisquare tests. Cox's proportional hazard models were used to calculate hazard ratios of mortality for age at menopause after adjusting for age, SBP, serum total cholesterol level, HDL cholesterol level, history of diabetes mellitus, BMI, smoking habits, alcohol drinking habits, marital status, study area, and type of menopause, which were considered to be potential confounding factors. Among the potential confounding factors that we obtained as the baseline data about blood pressure, we used SBP only in the multivariate analyses to avoid the co-linearity.This study was approved by the Institutional Review Board of Jichi Medical School for ethical issues.

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Section: Femalesmentioning

confidence: 99%

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confidence: 99%

Age at Menopause and Mortality in Japan: the Jichi Medical School Cohort Study

Amagai

Ishikawa

Gotoh

et al. 2006

Journal of Epidemiology

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“…The timing of natural menopause may serve as a marker for the process of reproductive ageing and as an indicator of postmenopausal women health risks. Earlier menopause was reported to increase the risk of several female age-related diseases, such as ovarian cancer [1,2], osteoporosis [3,4], and cardiovascular disease [5], whereas later menopause contributes to the higher risk of breast [6] and endometrial cancer [7]. Thus, knowing the determinants of age at natural menopause (ANM) may help to foreseen possible postmenopausal health complications.…”

Section: Introductionmentioning

confidence: 99%

A polymorphism of apolipoprotein E (APOE) gene is associated with age at natural menopause in Caucasian females

Recker

Deng

et al. 2009

Maturitas

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Objective-The present study aimed to investigate possible association of the apolipoprotein E (APOE) gene polymorphisms with age at natural menopause (ANM) in Caucasian females.Design-Four SNPs (including two replacements, SNP3 Cys112Arg and SNP4 Arg158Cys) were genotyped in 253 randomly selected unrelated Caucasian women having experienced natural menopause. The comprehensive statistical analyses focusing on the association of the APOE gene and some environmental factors with ANM were conducted.Results-Alcohol consumption was a significantly predictor of earlier natural menopause (P < 0.05). One SNP (rs769450) was significantly associated with ANM according to both population based and the transmission disequilibrium test (TDT) analyses (P = 0.007 and 0.046, respectively). However, no association was observed between APOE ε2,ε3, ε4 and ANM.Conclusions-Genetic variation in the APOE gene may influence the variation in ANM in Caucasian women.

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“…1–3 Later age at natural menopause has been associated with: longer overall survival and greater life expectancy 4 and reduced all-cause mortality 5 ;reduced risk of cardiovascular disease 4,6–11 and mortality from cardiovascular 12 and ischemic heart disease, 13 stroke, 14 angina after myocardial infarction, 15 and atherosclerosis 16 ;less loss of bone density, 17 and a reduced risk of osteoporosis 18 and fracture 19 ;but an increased risk of breast, 20,21 endometrial, and ovarian 4,22–25 cancers. In addition, women who have undergone bilateral oophorectomy under the age of 45 years have been observed to be at increased risk of mortality from cardiovascular disease, particularly if they were not treated with estrogen. 26 However, women who underwent natural menopause before age 45 years had an increased risk of ischemic heart disease that was not attenuated by use of hormone therapy.…”

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confidence: 99%