Age at menopause, body mass index, and risk of type 2 diabetes mellitus in postmenopausal Chinese women: The Henan Rural Cohort study

Zhang, Lulu; Bao, Lei; Li, Yuqian; Wang, Chongjian; Dong, Xiaokang; Abdulai, Tanko; Yang, Xiu; Fan, Mingxia; Cui, Songyang; Zhou, Wen; Mao, Zhenxing; Huo, Wenqian; Wei, Dandan; Li, Linlin

doi:10.1016/j.numecd.2020.04.003

Cited by 13 publications

(17 citation statements)

References 32 publications

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“…The mean BMI of the menopausal women was 24.44 ± 3.15 kg/m 2 in the overweight group according to the WHO classification for adults in Asia [16]. This index is like the results of other studies of 25.1 ± 3.6 kg/m 2 [21] and 24.2 ± 3.2 kg/m 2 [22], respectively. The central obesity rate was the majority in the group of menopausal women, specifically in Yong Sang Son's study 54.61%, and in our study, up to 87.5% [22].…”

Section: Characteristics Of the Research Objectsupporting

confidence: 76%

Characteristics of Rheoencephalography and some associated factors on menopausal women

Nguyen

Tran

et al. 2022

Journal of Electrical Bioimpedance

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The significant drop in estrogen levels during menopause increases the cardiovascular risks, one of which is cerebrovascular atherosclerosis. Research on rheoencephalography (REG) parameters for the early diagnosis of cerebrovascular atherosclerotic lesions is of great interest to scientists because of its ease of implementation, low cost, and non-invasiveness. The objectives of study are to evaluate the vascular tone, cerebral circulation flow in each hemisphere of the brain of menopausal women, and some associated factors through waveform characteristics and parameters in REG. A controlled cross-sectional descriptive study was conducted on a group of patients including 80 menopausal women and a control group of 46 menstruating women. All patients were measured REG in the frontal-occipital leads by VasoScreen 5000 impedance REG meter. In menopausal women, the percentage of sharp waves, the percentage of clear side waves, and the average REG were all lower than in the control group (p<0.01). The mean conduction time and mean slope ratio was lower than the control group (p<0.001). The mean peak time was higher than the control group (p<0.01). The mean elasticity index (alpha/T) was higher than the control group (p<0.001). Menopausal women have increased vascular tone, the highest in the group of women 50-60 years old, menopause <5 years, having a habit of eating red meat; and decreased blood flow intensity, the highest in the group of women <50 years old. However, the difference was statistically significant only in the left hemisphere (p<0.05). Vascular hypertonia in menopausal women with central obesity was higher than in the non-obese group in both hemispheres (p<0.05). In conclusion, menopausal women had atherosclerosis in both hemispheres of the brain, which was clearly shown in the rate of increased vascular tone. Central obesity may increase the risk of vascular hypertonia 3.75 times in the right and 5.44 times in the left hemisphere.

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Section: Characteristics Of the Research Objectsupporting

confidence: 76%

Characteristics of Rheoencephalography and some associated factors on menopausal women

Nguyen

Tran

et al. 2022

Journal of Electrical Bioimpedance

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“…Zhang et al . reported that the mean age at natural menopause was 48.8 years in Chinese women [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Association of age at menopause with type 2 diabetes mellitus in postmenopausal women in the United States: National Health and Nutrition Examination Survey 2011–2018

Xing¹,

Kirby²,

Alman³

2022

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Introduction The present study aimed to examine the impact of age at menopause on the type 2 diabetes mellitus (T2DM) risk in postmenopausal women. Material and methods We included 4,968 postmenopausal women from the National Health and Nutrition Examination Survey 2011–2018. Age at menopause was measured by single year and categorically (< 40 years, 40–44 years, 45–54 years, 55 years and above). The outcome variable T2DM was measured with self-report and fasting blood glucose level. We performed logistic regression to estimate the odds ratio (OR) (95% confidence interval [CI]). Linear regression was used to examine the correlation between age at menopause and age at T2DM. Results Of the 4,968 postmenopausal women, 796 (16.0%) had T2DM after menopause. The mean age at menopause was 44.2 years. The mean age at T2DM was 57.2 years. Adjusting for potential confounders, the ORs for the association between age at menopause of < 40 years, 40–44 years and ≥ 55 years and T2DM were 1.97 (95% CI: 1.47–2.63), 1.27 (95% CI: 0.90–1.79) and 0.98 (95% CI: 0.66–1.45), respectively, compared to women having menopause at age 45 to 54 years. Each increase by 1 year in age at menopause was associated with a 3% reduction in the prevalence of T2DM (95% CI: 2–5). Age at menopause was significantly correlated with age at T2DM. Each 1-year increase in age at menopause might lead to a decrease of 0.39 years in age at T2DM. Conclusions Premature menopause was associated with increased T2DM risk in women. The earlier menopause occurs, the younger is the age at which T2DM may occur.

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“…Previous studies on the association between age at menopause and diabetes differ in their results, finding that either early or late menopause was associated with increased risk of diabetes 17–20 . Several studies have used BMI stratification to estimate the role of obesity in the association between age at menopause and odds of diabetes, finding that earlier age at menopause with obesity increases the odds of diabetes 21,22 . Few studies considered the interaction of hypertension and dyslipidemia with age at menarche and menopause on the risk of diabetes.…”

Section: Introductionmentioning

confidence: 99%

“…[17][18][19][20] Several studies have used BMI stratification to estimate the role of obesity in the association between age at menopause and odds of diabetes, finding that earlier age at menopause with obesity increases the odds of diabetes. 21,22 Few studies considered the interaction of hypertension and dyslipidemia with age at menarche and menopause on the risk of diabetes. Research is also still lacking on the association of age at menarche and age at menopause with diabetes in Southwestern China.…”

Section: Introductionmentioning

confidence: 99%

Associations of age at menarche and age at menopause with diabetes among postmenopausal women in Chongqing, China

Yuan

Xiao

et al. 2022

J of Obstet and Gynaecol

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Background: Existing studies on the association of age at menarche and age at natural menopause with diabetes are conflicting. Objective: To explore the associations of age at menarche and age at natural menopause with diabetes, and to estimate whether body mass index, abdominal obesity, hypertension, and dyslipidemia would influence the relationships. Methods: In this cross-sectional study, 5090 postmenopausal women were included from the China Multi-Ethnic Cohort Study (CMEC) baseline in Chongqing province. Questionnaires, physical examinations, and biological samples testing were conducted. Logistic regression was used to generate odds ratios (ORs) and 95% confidence intervals (CIs). And restricted cubic splines were performed to evaluate the pattern of association between ages at menarche and menopause with diabetes. Results: The adjusted ORs for diabetes grouped by age at menarche (<12, 12-17, >17 years) were 0.76 (95%CI: 0.42-1.40), 1.00 (reference), and 0.73 (95%CI: 0.57-0.94). Similarly, the adjusted ORs for diabetes grouped by age at menopause (<44, 44-52, >52 years) were 1.38 (95%CI: 1.04-1.82), 1.00 (reference), and 1.11 (95%CI: 0.89-1.39). No significant interaction of age at menarche and menopause with body mass index, abdominal obesity, hypertension, and dyslipidemia in odds of diabetes was observed. Conclusion: Late menarche is associated with a lower prevalence of diabetes, while early natural menopause is associated with a higher prevalence of diabetes. No significant effect modification was observed by body mass index, abdominal obesity, hypertension, or dyslipidemia.

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Age at menopause, body mass index, and risk of type 2 diabetes mellitus in postmenopausal Chinese women: The Henan Rural Cohort study

Cited by 13 publications

References 32 publications

Characteristics of Rheoencephalography and some associated factors on menopausal women

Characteristics of Rheoencephalography and some associated factors on menopausal women

Association of age at menopause with type 2 diabetes mellitus in postmenopausal women in the United States: National Health and Nutrition Examination Survey 2011–2018

Associations of age at menarche and age at menopause with diabetes among postmenopausal women in Chongqing, China

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