Age at onset predicts good seizure outcome in sporadic non-lesional and mesial temporal sclerosis based temporal lobe epilepsy

Abstract

Results. At univariate analysis, patients achieving 24-month seizure freedom had significantly older age at onset of epilepsy (33.5 +19.9 vs. 17.2 +14.4 years), lower occurrence of febrile seizures (11.0% vs 24.4%) and MTS (19.0% vs. 35.6%). The chance of remission was directly correlated to the age at onset of seizures and inversely correlated to a history of febrile seizures and to the presence of MTS. At multivariate analysis, age at onset of epilepsy was the only significant prognostic predictor. Conclusion.Older age at onset predicts better prognosis in sporadic, non-lesional TLE.Aguglia, 4

Age at onset in patients with medically refractory temporal lobe epilepsy and mesial temporal sclerosis: Impact on clinical manifestations and postsurgical outcome

“…In a previous study of surgery for temporal lobe epilepsy with hippocampal involvement in preadolescent children [11], outcomes at the last follow-up examination were categorized as Engel Class I-II in 20 (76.9%) of 26 children with confirmed MTS, which is comparable to adult studies. This finding is in contrast with the findings in a previous study, in which 190 patients with TLE were analyzed and older age at onset predicted better postsurgical prognosis [8]. However, their inclusion criteria were different from ours, as they included patients with normal MRI in addition to those with MTS.…”

“…Besides, even in many adults with MTS-TLE a detailed clinical history will clarify that the age at onset of the habitual seizures was in childhood [7]. It has been previously reported that, older age at onset of epilepsy predicts better prognosis in patients with TLE [8].…”

T2 hyperintense signal in patients with temporal lobe epilepsy with MRI signs of hippocampal sclerosis and in patients with temporal lobe epilepsy with normal MRI

“…Another study found differences in the hippocampal histopathology of patients with TLE with or without family history of epilepsy, with more pronounced mossy fiber sprouting in the fascia dentate of sporadic TLE [19]. However, no difference in the surgical outcome has been observed in patients with TLE with or without family history of epilepsy [20].…”

Epilepsy associated with Leukoaraiosis mainly affects temporal lobe: a casual or causal relationship?

“…In PSE group, the abnormal EEG findings were probably caused by damage due to well-evident cerebral infarction. However, the high proportion of temporal lobe epilepsy, especially with a deep, mesial focus, in EAL group could account for a significant proportion of normal interictal EEGs, as described elsewhere (Aguglia et al, 2011;Labate et al, 2011).…”