Age at primary infection with Salmonella enterica serovar Typhimurium in the chicken influences persistence of infection and subsequent immunity to re-challenge

Beal, Richard K.; Wigley, Paul; Powers, Claire; Hulme, Scott; Barrow, Paul; Smith, Adrian L.

doi:10.1016/j.vetimm.2004.04.005

Cited by 150 publications

(128 citation statements)

References 43 publications

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“…This result confirms that, with ageing, the development and maturity of the bird lymphoid tissue associated to the intestine and the establishment of the normal microbiota was possible (Beal et al, 2004;Andrade et al, 2007).…”

Section: Resultssupporting

confidence: 77%

“…This fact can be related to a natural age-based immune resistance to enteropathogens, which are related to the development of the gut-associated lymphoid tissue (GALT), and the establishment of the beneficial intestinal microbiota, in the first weeks of age (Bohórquez et al, 2011). At 24 days of age, no statistical difference was observed in the frequency of Salmonella Typhimurium excretion between the treatments (Table 5).…”

Section: Resultsmentioning

confidence: 99%

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Performance of broilers experimentally inoculated with Salmonella Typhimurium and fed diets with addition of lactulosis

et al. 2012

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-The objective of this experiment was to evaluate the influence of lactulose on performance as well as its ability to prevent colonization by Salmonella Typhimurium in broilers orally inoculated with this pathogen. The design adopted was completely randomized, with 630 one-day-old male chicks distributed into six treatments, with seven replications and 15 birds per experimental unit. The treatments comprised the following procedures: T1 (control group) -no S.Typhimurium inoculation or supply of lactulosis; T2 -only inoculation of S. Typhimurium; T3 -only lactulosis supply; T4 -supply of lactulosis and S. Typhimurium inoculation on the first day of life; T5 -supply of lactulosis 48 hours before S.Typhimurium inoculation; and T6 -supply of lactulosis 48 hours after inoculation of S. Typhimurium. Performance variables were evaluated on the seventh, 14th, 21st and 28th days of age; fragments of the duodenum and jejunum were collected and sent to histomorphometric assessment at 14 days of age, and S. Typhimurium excretion was verified in cloacal swabs on the 10th, 24th and 35th days of age. Performance data were analyzed by ANOVA and Tukey's test (5%) and fecal excretion data were assessed by non-parametric chi-square test. Better weight gain and feed conversion were observed in groups fed lactulosis with or without challenge of S. Typhimurium up to 21 days of age. Reduced duodenum villous height was verified on the 14th day in groups challenged with the pathogen. Reduction of S. Typhimurium fecal excretion was verified in broilers fed lactulosis from the first day of life on and 48 hours before receiving S. Typhimurium directly into the crop. Lactulosis increases broiler performance up to one week after its inoculation, influences duodenum villous height and reduces the fecal excretion of Salmonella Typhimurium.

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Section: Resultssupporting

confidence: 77%

Section: Resultsmentioning

confidence: 99%

Performance of broilers experimentally inoculated with Salmonella Typhimurium and fed diets with addition of lactulosis

et al. 2012

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“…Desmidt et al (1997) reported that, by aging, the specific and non-specific immunological defense mechanisms are capable of impairing Salmonella infection, which can be attributed to the development of the cellular and humoral immune system on the first days of life. Beal et al (2004) orally challenged chicks at one, three and six weeks of age with 10 8 CFU of Salmonella Typhimurium and verified that older birds, with a welldeveloped immune system, showed a faster response to eliminate the inoculated agents. Barrow (2000) confirmed that the invasion mechanism and capacity of Salmonella depends on the age of bird and the way the agent contaminates the organs.…”

Section: Resultsmentioning

confidence: 74%

Performance and intestinal health of broilers inoculated with nalidixic acid-resistant Salmonella Typhimurium and treated with organic acids

et al. 2011

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-An experiment with 630 one-day-old chicks experimentally inoculated with Salmonella Typhimurium was performed to evaluate the effects of an organic acid blend (benzoic, fumaric and 2-hydroxi-4-methylltio-butanoicHMTBa) on intestinal health and performance. The experimental challenge with Salmonella Typhimurium occurred in two different routes of administration: via crop on the first day after hatching, and via feed, offered from seven to 14 days of age. These groups were treated with organic acids in a 3 × 2 (agent versus acid) factorial arrangement. Chicks treated with organic acids had higher weight gain, mean live weight and better feed conversion at 14 days of age, and higher weight gain at 28 days of age. Chicks treated with organic acids inoculated via crop had higher duodenum villi height than animals of the control group.Jejunum villi were higher in chicks of the negative control group compared with birds supplemented with organic acids. Small intestine pH in chicks of the inoculated group was lower compared with control group throughout the trial period. HMTBa acid in the dosage of 0.4% improves intestinal health and performance when nalidixic acid resistant Salmonella Typhimurium is experimentally inoculated.

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“…Beal et al (2004) pointed to the importance of knowing ST excretion frequency, because, they observed, experimentally infected broiler chicks may have intestinal colonization in 90% of the cases and still show no clinical signs of salmonellosis. Although we observed diarrhea in the first three sampling time points, in the fourth and last time point, these signs could not be observed possibly because of the chick immune response.…”

Section: Discussionmentioning

confidence: 99%

Experimental infection of broiler chicks with Salmonella Typhimurium from pigeon (Columba livia)

Albuquerque

Teixeira

Machado

et al. 2016

SCA

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Several cases of animal and human salmonellosis caused by the Salmonella serotype Typhimurium have been reported. In animals, subclinical infection favors pathogen dissemination through feces. In this context, the domestic pigeon (Columba livia) with an asymptomatic condition may play an important role in the transmission of salmonellosis, through the elimination of contaminated feces in commercial aviaries or in poultry feed facilities, causing economic losses to the poultry industry and presenting a risk to public health. This study aimed to evaluate the mortality, clinical signs and the presence of Salmonella Typhimurium in the feces and organs of chicks previously inoculated with bacteria isolated from a pigeon. One-day-old chicks were distributed in two experimental groups (G1 and G2) of 32 birds each, and a control group of six birds. Two inocula of 0.4 and 0.7 mL with 10 5 and 10 6 colony forming units were used in G1 and G2 birds, respectively. At 1, 4, 7 and 14 days post-inoculation (dpi) fecal samples were pooled from each cage and individual cloacal swabs were collected. At 14 dpi, all chicks were euthanized and samples were collected from the liver, spleen, lung, cecum and intestine for microbiological analysis. Mortality was only observed among G2 birds (6.25%). Most birds presented clinical signs of diarrhea at 4 dpi and no symptom as observed at 14 dpi. The results from cloacal swabs demonstrated bacterial elimination in 68.8% and 53.1% of G2 and G1 birds, respectively at 1 dpi. Additionally, fecal samples had elevated bacterial shedding in all four periods of observation , with a higher excretion at 4 dpi (62.5%) for both groups. Among G2 birds, 74.2% were positive for the pathogen in the intestine; G1 birds presented the lowest rate of lung infection (29%), and both groups had more than 50% positivity for liver and caeca. The results revealed that infected chicks with a Salmonella Typhimurium strains isolated from pigeons may host the pathogen in several organs, and simultaneously present diarrheic disorders with significant levels of bacterial excretion in feces. ResumoNa literatura são relatados diversos casos de salmonelose em animais e humanos em vários países ocasionados pelo sorotipo Typhimurium. Em animais, a infeção subclínica favorece a disseminação do patógeno através das fezes. Nesse contexto, o pombo (Columba livia) com quadro assintomático pode desempenhar um importante papel na transmissão de salmonelose, mediante a excreção de fezes contaminadas em aviários comerciais ou em instalações de ração animal causando perdas econômicas para a indústria avícola, e proporcionando risco para a saúde pública. Objetivou-se avaliar a taxa de mortalidade, sinal clínico e a presença de Salmonella Typhimurium nas fezes e nos órgãos de pintinhos previamente inoculados com bactérias oriundas de pombo. Foram utilizados 70 pintos de corte de um dia de idade, os quais foram distribuídos aleatoriamente em dois grupos (G1 e G2) de 32 aves cada. Utilizou-se um grupo controle, constituído por seis...

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Age at primary infection with Salmonella enterica serovar Typhimurium in the chicken influences persistence of infection and subsequent immunity to re-challenge

Cited by 150 publications

References 43 publications

Performance of broilers experimentally inoculated with Salmonella Typhimurium and fed diets with addition of lactulosis

Performance of broilers experimentally inoculated with Salmonella Typhimurium and fed diets with addition of lactulosis

Performance and intestinal health of broilers inoculated with nalidixic acid-resistant Salmonella Typhimurium and treated with organic acids

Experimental infection of broiler chicks with Salmonella Typhimurium from pigeon (Columba livia)

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