Age changes of motor innervation and acetylcholine receptor distribution on human skeletal muscle fibres

Oda, Kenichiro

doi:10.1016/0022-510x(84)90021-2

Cited by 136 publications

(83 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Aged rats may compensate for this AChR loss by changes in threshold endplate potentials (safety factors) or by increasing their quantal release more efficiently to compensate for the decreased postsynaptic sensitivity resulting from AChR loss [42]. Moreover, differences in susceptibility might be explained by changes at the endplate in aged rats, such as increased length and branching of the postsynaptic membrane and enlargement of the postsynaptic area, or wider spacing of the AChR molecules [43][44][45][46].…”

Section: Discussionmentioning

confidence: 99%

Age- and sex-related resistance to chronic experimental autoimmune myasthenia gravis (EAMG) in Brown Norway rats

Hoedemaekers¹,

Graus²,

Vriesman³

et al. 1997

Clinical and Experimental Immunology

View full text Add to dashboard Cite

SUMMARYThe influence of age and sex on the induction of chronic EAMG was analysed. Aged male rats, immunized with Torpedo acetylcholine receptor (tAChR), showed no clinical signs of disease or AChR loss. Immunization of young male Brown Norway (BN) rats resulted in both clinical signs of disease and 65% AChR loss. In contrast, both young and aged female BN rats showed comparable AChR loss (58% and 50%, respectively), although aged female rats did not develop clinical signs of disease. Differences in antibody titres, isotype distribution, fine specificity or complement activation could not account for the observed resistance. These results suggest that resistance against EAMG in aged rats is due to resistance of the AChR against antibody-mediated degradation, or to mechanisms able to compensate for AChR loss.

show abstract

Section: Discussionmentioning

confidence: 99%

Age- and sex-related resistance to chronic experimental autoimmune myasthenia gravis (EAMG) in Brown Norway rats

Hoedemaekers¹,

Graus²,

Vriesman³

et al. 1997

Clinical and Experimental Immunology

View full text Add to dashboard Cite

show abstract

“…For example, structural alterations at the NMJ correlate with age (329,460), but a correlation neither with sarcopenic muscle nor with NMJ function has been established. Specifically, age-dependent morphological changes include an increase in the length, the branching, and the overall area of the postsynaptic membrane and increased perijunctional AChR labeling near old NMJs (329). Electron microscopy revealed the presence of degenerating synaptic folds that were often not opposed by a presynaptic nerve terminal.…”

Section: Human Studiesmentioning

confidence: 97%

Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting

Tintignac

Brenner

Rüegg

2015

Physiological Reviews

332

341

View full text Add to dashboard Cite

The neuromuscular junction is the chemical synapse between motor neurons and skeletal muscle fibers. It is designed to reliably convert the action potential from the presynaptic motor neuron into the contraction of the postsynaptic muscle fiber. Diseases that affect the neuromuscular junction may cause failure of this conversion and result in loss of ambulation and respiration. The loss of motor input also causes muscle wasting as muscle mass is constantly adapted to contractile needs by the balancing of protein synthesis and protein degradation. Finally, neuromuscular activity and muscle mass have a major impact on metabolic properties of the organisms. This review discusses the mechanisms involved in the development and maintenance of the neuromuscular junction, the consequences of and the mechanisms involved in its dysfunction, and its role in maintaining muscle mass during aging. As life expectancy is increasing, loss of muscle mass during aging, called sarcopenia, has emerged as a field of high medical need. Interestingly, aging is also accompanied by structural changes at the neuromuscular junction, suggesting that the mechanisms involved in neuromuscular junction maintenance might be disturbed during aging. In addition, there is now evidence that behavioral paradigms and signaling pathways that are involved in longevity also affect neuromuscular junction stability and sarcopenia.

show abstract

“…The NMJ plays a critical role in the conduction of action potentials from motor neuron to muscle fiber. Several studies have shown that human aging is associated with the gradual loss of motor neurons and morphological changes in the NMJ and its remodeling (22,23). The changes in NMJ morphology precede a functional impairment in the post-synaptic response of the NMJ, i.e., reduction in motor nerve conduction velocity and the amplitude of compound muscle action potential (24).…”

Section: Discussionmentioning

confidence: 99%

Effects of Nutritional Supplementation with Milk Fat Globule Membrane on Physical and Muscle Function in Healthy Adults Aged 60 and Over with Semiweekly Light Exercise: A Randomized Double-Blind, Placebo-Controlled Pilot Trial

Minegishi

Ota

Soga

et al. 2016

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

View full text Add to dashboard Cite

SummaryThis study aimed to demonstrate the beneficial effects of nutritional supplementation with dietary milk fat globule membrane (MFGM) on physical performance and skeletal muscle function in healthy adults aged 60 and over with semiweekly light exercise. The study was designed as a randomized double-blind controlled trial. Twenty-two Japanese participants (10 men, 12 women) aged 60-73 y were assigned to one of two groups (11 [5 men, 6 women] in each). One group received MFGM tablets (1 g MFGM/d), and the other received placebo tablets daily for 10 wk. Both groups participated in a twice-weekly light exercise program. Physical function tests and surface electromyography (EMG) were conducted at the baseline and after 5 and 10 wk. Chair stand time significantly shortened in both groups after 10 wk compared with that at the baseline. The average time shortened more considerably in the MFGM group than in the placebo group, although the change was not statistically significant. Both knee extension strength and the cross-sectional area of the quadriceps muscles significantly increased from baseline in the MFGM group but not in the placebo group. Surface EMG showed that muscle fiber conduction velocity increased significantly after 10 wk from the baseline only in the MFGM group. The increase from the baseline was significantly greater in the MFGM group than in the placebo group. Daily supplementation with MFGM increased motor unit action potential conduction and improved muscle strength and physical performance in healthy Japanese adults aged 60 y and over paired with semiweekly light exercise.

show abstract

Age changes of motor innervation and acetylcholine receptor distribution on human skeletal muscle fibres

Cited by 136 publications

References 17 publications

Age- and sex-related resistance to chronic experimental autoimmune myasthenia gravis (EAMG) in Brown Norway rats

Age- and sex-related resistance to chronic experimental autoimmune myasthenia gravis (EAMG) in Brown Norway rats

Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting

Effects of Nutritional Supplementation with Milk Fat Globule Membrane on Physical and Muscle Function in Healthy Adults Aged 60 and Over with Semiweekly Light Exercise: A Randomized Double-Blind, Placebo-Controlled Pilot Trial

Contact Info

Product

Resources

About