Age, comorbidity burden and late presentation are significant predictors of hospitalization length and acute respiratory failure in patients with influenza

Miron, Victor Daniel; Săndulescu, Oana; Streinu-Cercel, Anca; Florea, Dragoș; Paraschiv, Simona; Bănică, Leontina; Vlaicu, Ovidiu; Oțelea, Dan; Bilașco, Anuța; Pițigoi, Daniela; Streinu-Cercel, Adrian; Drăgănescu, Anca Cristina

doi:10.1038/s41598-024-66550-8

Cited by 2 publications

References 26 publications

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Gender Differences in Stress and Upper Respiratory Tract Infections: A Closer Look

Rüthrich,

Ascone,

Hammersen

et al. 2024

Preprint

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Background: Infectious diseases are influenced by both sex and gender, with psychosocial stress potentially playing a critical role, particularly in upper respiratory tract infections (URTIs). Despite existing evidence, a comprehensive analysis of the interplay between sex, gender, stress, and RTIs is lacking. Methods: Our monocentric, prospective study included 273 healthy individuals (cohort H) and 194 patients with hematological cancer (cohort P) who had undergone stem cell transplantation, enrolled between 11/2013 and 05/2017. Eligible participants were aged 18 years or older. Data collection encompassed demographics, household composition, smoking behavior, cancer-related characteristics, RTI-symptoms, and perceived stress, measured using the 4-item perceived stress scale (PSS-4). Participants were categorized based on biological sex, without assessing gender identity. For analysis, we assumed that sex and gender were aligned. Results: In cohort H, 50% of the participants were female, with most individuals aged ≤ 30 years. Women experienced notably more moderate to severe URTI symptoms than men (57% vs. 36%, p < .001, φ = 0.210). Additionally, women across all age groups also exhibited higher PSS-4 levels than men [t(271) = 2.84, p < .001, d = -0.636] and the PSS-4 was significantly affected by sex [F(1, 261) = 22.22, p < 0.001, η2 0.078]. In cohort P, 40.5% of the patients were female, with the majority aged ≥ 30 years. The occurrence and severity of RTI symptoms were more pronounced in men than women. The PSS-4 was not affected by sex. Unlike in cohort H, a significant correlation between the PSS-4 and RTI symptoms was found for both sexes in cohort P. In both groups, the lowest stress levels were observed in individuals over 60 years old. Conclusion Perceived stress was higher in younger women, as was the occurrence and severity of URTIs. However, a significant correlation between stress and URTIs was found only in patients with cancer, suggesting a more complex interaction between sex, gender, stress and URTIs in individuals with compromised health as compared to healthy individuals, which deserves further study. Trial registration: Registry: the German Clinical Trials Register

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Gender Differences in Stress and Upper Respiratory Tract Infections: A Closer Look

Rüthrich,

Ascone,

Hammersen

et al. 2024

Preprint

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Antigenic Divergence from the Seasonal Vaccine of the Influenza Virus Strains Circulating in Romania During Three Successive Seasons (2021–2024)

Vlaicu,

Banica,

Hohan

et al. 2024

Microorganisms

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Influenza viruses continue to be an important public health threat. Vaccination is the most effective measure to control the influenza virus circulation. However, these viruses are continuously evolving through antigenic drift/shift, and thus the vaccine efficiency is affected. The aim of this study was to characterize the viral strains circulating in Romania, in a population with declining vaccination coverage, during the last three cold seasons by evaluating the hemagglutinin antigenic relatedness to the vaccine strains. All the available sequences collected between August 2021 and June 2024 were analyzed by using phylogenetic analysis and the Pepitope model to predict vaccine efficacy. The results showed that the 2021/2022 influenza season was dominated by the circulation of highly diverse clades of A(H3N2) viruses with high mutational divergence as compared to the vaccine strain, which might contribute to the reduction in vaccine efficacy. During the 2022/2023 influenza season, both influenza A and B viruses were reported, with few antigenic site mutations. The 2023/2024 influenza season was dominated by the circulation of influenza A viruses: A/H1N1pdm09 clade 6B.1A.5a.2a and A/H3N2 clade 2a.3a.1. The clade 2a.3a.1 also showed high variability when compared to the vaccine strain, presumably leading to reduced vaccine efficacy. This study illustrates the high diversity of influenza viruses circulating in a population with low vaccination coverage during the previous cold seasons. The viral diversity impacted vaccine efficacy, hence the need for public health programs to increase vaccine uptake and improve vaccine formulation in order to limit viral transmission.

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Age, comorbidity burden and late presentation are significant predictors of hospitalization length and acute respiratory failure in patients with influenza

Cited by 2 publications

References 26 publications

Gender Differences in Stress and Upper Respiratory Tract Infections: A Closer Look

Gender Differences in Stress and Upper Respiratory Tract Infections: A Closer Look

Antigenic Divergence from the Seasonal Vaccine of the Influenza Virus Strains Circulating in Romania During Three Successive Seasons (2021–2024)

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