Age dependence of ocular biometric measurements under cycloplegia with tropicamide and cyclopentolate

Comparison of tropicamide and cyclopentolate for cycloplegic refractions in myopic adult refractive surgery patients

“…12,13 Several studies have compared cyclopentolate to tropicamide in children. [1][2][3][4][5][6] These studies found cyclopentolate to be slightly more efficacious than tropicamide but noted that the differences between the 2 were small and would not significantly influence a prescription for treatment of the refractive error. In adults, there have been few studies comparing various cycloplegic agents.…”

“…Studies in children have suggested that cyclopentolate and tropicamide might be equally efficacious for cycloplegic refractions. [1][2][3][4][5][6] There have been only 2 studies comparing cyclopentolate and tropicamide in adult populations. The first, published in 1961, showed that both medications decreased accommodation to a similar degree but that accommodation returned much more quickly with tropicamide.…”

Cycloplegic Refraction in Hyperopic Children: Effectiveness of a 0.5% Tropicamide and 0.5% Phenylephrine Addition to 1% Cyclopentolate Regimen

“…Early studies [1011] report that the cycloplegic effect of tropicamide is much less than that of atropine or cyclopentolate, and that it is insufficient for cycloplegic refraction in children. In contrast, more recent studies have suggested that cyclopentolate and tropicamide may be equally efficacious for refractive measurements [6121314]. Hyperopic children generally have greater accommodative efforts in comparison to myopic children with relatively lower accommodation requirements [1516].…”

Cycloplegia in refraction: age and cycloplegics

“…The purpose of the article was to investigate the appropriate age cut-off for cycloplegia in refraction, but the comparison should have been made with drugs that offer the same cycloplegic potential. Several studies have shown that cyclopentolate has more cycloplegic effect than tropicamide and it reduces the accommodative amplitude in adults (Mutti et al 1994;Owens et al 1998;Hofmeister et al 2005). The authors concluded that cycloplegia is not required to provide an estimation of refractive error for adults; we believe that one cannot come to this conclusion being as tropicamide was used in the adult group.…”

“…However, what is much less clear is whether these differences translate to meaningful clinical effects -a reflection of the importance of interpreting effect size in statistical analysis. Accordingly, there are several studies that would suggest tropicamide is a useful cycloplegic agent in many circumstances (Egashira et al 1993;Mutti et al 1994;Owens et al 1998;Manny et al 2001;Nawrot et al 2012). It is interesting to note that the largest genomewide association study of myopia utilized a participant reported rather than clinically based phenotype (Kiefer et al 2013).…”