Age-dependence of risk factors for carotid stenosis: an observational study among candidates for coronary arteriography

Zimarino, Marco; Cappelletti, L; Venarucci, Vincenzo; Gallina, Sabina; Scarpignato, Maurizio; Acciai, N; Calafiore, Antonio M.; Barsotti, Antonio; Caterina, Raffaele De

doi:10.1016/s0021-9150(01)00477-4

Cited by 37 publications

(19 citation statements)

References 29 publications

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“…47 Moreover, the role of CRFs in influencing not only the protective effects of PIA but also, in general, the pathogenesis of atherosclerotic disease, is now well known. 48 In our study, we expanded these previous observations by showing that, specifically, CRFs may modulate the PIA-mediated reduction in the MVO rate. In particular, we show that this modulation is significant for hypertension, smoking habit, dyslipidemia and familiar history of cardiovascular disease.…”

Section: Discussionsupporting

confidence: 56%

Protective Effect of Pre-Infarction Angina on Microvascular Obstruction After Primary Percutaneous Coronary Intervention Is Blunted in Humans by Cardiovascular Risk Factors

Niccoli

Scalone

Cosentino

et al. 2014

Circ J

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Section: Discussionsupporting

confidence: 56%

Protective Effect of Pre-Infarction Angina on Microvascular Obstruction After Primary Percutaneous Coronary Intervention Is Blunted in Humans by Cardiovascular Risk Factors

Niccoli

Scalone

Cosentino

et al. 2014

Circ J

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“…In a population study of Ͼ16 000 people, 90% of subjects affected with severe carotid lesions were Ͼ55 years of age. 4 Age is the primary risk factor for carotid artery disease, 5 and examining an elderly patient group may mask the effects of risk factors of early atherosclerosis. Therefore, in the present study, we tried to identify the role of several potential risk factors of early atherosclerosis in a case-control study in subjects Ͻ55 years of age.…”

mentioning

confidence: 99%

Early-Onset Carotid Atherosclerosis Is Associated With Increased Intima-Media Thickness and Elevated Serum Levels of Inflammatory Markers

Magyar

Szikszai

Balla

et al. 2003

Stroke

132

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Background and Purpose-Several factors have been held responsible for the development of atherosclerosis. To avoid the masking effect of age, we evaluated correlates of carotid atherosclerosis in patients Ͻ55 years of age. Methods-Plasma lipids, oxidative resistance of low-density lipoprotein, homocysteine, inflammatory markers, plasma viscosity, and red cell deformability were measured in fasting blood samples of 100 subjects: 45 patients with Ͼ30% stenosis of the internal carotid artery, 20 patients with carotid occlusion, and 35 control subjects. Stenosis and intima-media thickness (IMT) of the carotid artery were evaluated by duplex ultrasound. Results-White blood cell (WBC) count, plasma fibrinogen, C-reactive protein (CRP), and lipoprotein(a) levels were significantly higher in patients than in control subjects, and patients had increased IMT (PϽ0.01 for all comparisons). There was a tendency for higher homocysteine levels in patients. Smokers had higher WBC, fibrinogen, and CRP levels. After the effect of smoking was controlled for, WBC count, natural logarithmic transform of homocysteine, and online-measured IMT remained significantly higher in patients than in control subjects. WBC, fibrinogen, and CRP levels were highest in the highest IMT quartile (Pϭ0.012, Pϭ0.007, and Pϭ0.036, respectively). Conclusions-Inflammatory markers and homocysteine have a more important role than lipid factors in early-onset carotid atherosclerosis. We cannot recommend the measurement of low-density lipoprotein peroxidation as a routine screening test to identify high-risk patients for early-onset carotid atherosclerosis. The confounding effect of smoking on inflammatory markers should be considered in studies on atherosclerosis.

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“…Recent studies demonstrated a significantly faster annual growth rate in diabetic patients compared with in other men presenting with lower urinary tract symptoms [15], and that diabetes is associated with greater BPH symptom severity even after age adjustment [6]. Long-lasting diabetes mellitus has repeatedly been shown to be an indicator disease for arteriosclerosis and to represent an independent predictor of significant arteriosclerosis [16,17], as diabetes is significantly and positively associated with intima media thickness [18][19][20]. Up to now, however, the causal association of vascular damage and BPH remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Vascular damage induced by type 2 diabetes mellitus as a risk factor for benign prostatic hyperplasia

et al. 2005

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Aims/hypothesis: The aim of this study was to evaluate the relationship between benign prostatic hyperplasia (BPH) and arteriosclerosis shown in a model of type 2 diabetes in a trans-sectional population study using contrast-enhanced colour Doppler ultrasound for exact assessment of prostatic blood flow. Methods: Contrast-enhanced transrectal colour Doppler ultrasound was performed using a microbubble-based ultrasound enhancer SonoVue for evaluating prostate vascularity (transitional zone [TZ] and peripheral zone [PZ]) in diabetic BPH patients, non-diabetic BPH patients and healthy subjects. Computer-assisted quantification of colour pixel intensity (CPI) was used to objectively evaluate the prostate vascularity. Resistive index measurements were obtained in the TZ and the PZ. Findings were compared between these three groups. Results: TZ-CPI was significantly lower in diabetic patients than in non-diabetic BPH men (p=0.001), whereas the CPI of the PZ showed no difference between these two groups (p=0.978). TZ-CPI of patients with diabetic and non-diabetic BPH were significantly lower than in controls (p<0.001), but no difference was found between diabetic and healthy patients in the PZ (p=0.022) and borderline significance was seen when comparing patients of the BPH group with the control patients (p=0.019). Resistive index values of the TZ in diabetic patients showed significantly higher values (p<0.001) than the BPH and control groups. Conclusions/interpretation: The significantly lower CPI and higher resistive index values of the TZ in diabetic patients compared with patients with nondiabetic BPH and healthy subjects indicate considerable vascular damage in the TZ of these patients. Diabetic vascular damage may cause hypoxia and may contribute to the pathogenesis of BPH.

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Age-dependence of risk factors for carotid stenosis: an observational study among candidates for coronary arteriography

Cited by 37 publications

References 29 publications

Protective Effect of Pre-Infarction Angina on Microvascular Obstruction After Primary Percutaneous Coronary Intervention Is Blunted in Humans by Cardiovascular Risk Factors

Protective Effect of Pre-Infarction Angina on Microvascular Obstruction After Primary Percutaneous Coronary Intervention Is Blunted in Humans by Cardiovascular Risk Factors

Early-Onset Carotid Atherosclerosis Is Associated With Increased Intima-Media Thickness and Elevated Serum Levels of Inflammatory Markers

Vascular damage induced by type 2 diabetes mellitus as a risk factor for benign prostatic hyperplasia

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