Age dependence of ultraviolet light‐induced erythema following narrow‐band UVB exposure

Gloor, M.; Scherotzke, A.

doi:10.1034/j.1600-0781.2002.00756.x

Cited by 28 publications

(19 citation statements)

References 19 publications

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“…However, a significant degree of apoptosis was already observed at the doses of about 800–1000 mJ/cm 2 depending on studied cell types and conditions of irradiation [20,22]. Importantly, an apoptotic dose of NB-UVB is very similar to the minimal erythema dose (MED) of NB-UVB observed by Gloor and Scherotzke [32] in Caucasian subjects, indicating that indeed UV-induced erythema might be an inflammatory response to the appearance of “sunburn cells” ( i.e ., apoptotic cells) in native human epidermis. Broad-band UVB and NB-UVB at equivalent MED doses were equally potent in inducing p53 and p16 expression as well as apoptosis in healthy volunteers [33].…”

Section: Narrow Band Uvb (311 Nm) and Apoptosis Of Keratinocytesmentioning

confidence: 68%

Effects of Narrow Band UVB (311 nm) Irradiation on Epidermal Cells

Reich

Mędrek

2013

IJMS

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Ultraviolet radiation (UVR) is known to be one of the most important environmental hazards acting on the skin. It was revealed that chronic exposure to UVR accelerates skin aging, induces immunosuppression and may lead to the development of skin cancers. On the other hand, UVR has been shown to be effective in the treatment of numerous skin diseases and thus, various phototherapy modalities have been developed to date. Narrow-band ultraviolet B (NB-UVB) emitting a light with a peak around 311 nm has been demonstrated to be effective in the treatment of various skin disorders; currently it is one of the most commonly used phototherapy devices. Despite NB-UVB has been developed more than 30 years ago, the exact mechanism of its therapeutic action remains poorly understood. To date, most of NB-UVB effects were attributed to its influence on immune cells; however, nearly 90% of NB-UVB irradiation is absorbed by epidermis and keratinocytes seem to be important players in mediating NB-UVB biological activity. Here, we have reviewed the current data about the influence of NB-UVB on epidermal cells, with a special emphasis on cell proliferation and death.

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Section: Narrow Band Uvb (311 Nm) and Apoptosis Of Keratinocytesmentioning

confidence: 68%

Effects of Narrow Band UVB (311 nm) Irradiation on Epidermal Cells

Reich

Mędrek

2013

IJMS

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“…The subjects' ages in the present study range from 15 to 50 years. It has been shown that UVB radiation causes more intensive erythema in older subjects [41] and induces a more dramatic increase in TEWL in younger mice (27 weeks old) than in older ones, which shows a minimum increase (90 weeks old) [42] . Although suberythemal UVB radiation accelerates barrier recovery in the animal model [37] , in the present study no dramatic difference in barrier recovery was observed between control and lower doses of sun exposure.…”

Section: Discussionmentioning

confidence: 99%

Sun-Induced Changes in Stratum Corneum Function Are Gender and Dose Dependent in a Chinese Population

Liu

Fluhr

Shu-min

et al. 2010

Skin Pharmacol Physiol

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Previous studies have demonstrated that UVB radiation changes the epidermal permeability barrier and stratum corneum (SC) hydration. It is well known that sun exposure causes erythema, sunburn and melanoma. However, whether daily sun exposure alters SC integrity and epidermal permeability barrier function is largely unknown, especially in Chinese subjects. In the present study, we assess the SC integrity, SC hydration and epidermal permeability barrier function following various doses of sun exposure. A total of 258 subjects (124 males and 134 females) aged 18–50 years were enrolled. A multifunctional skin physiology monitor (Courage & Khazaka MPA5) was used to measure SC hydration and transepidermal water loss (TEWL) on the forearms. In males, basal TEWL was higher with higher doses of sun exposure than with lower doses and control, whereas in females, basal TEWL was higher with lower doses of sun exposure than with higher doses and control. In the group with higher doses of sun exposure, TEWL in females was significantly lower than that in males. The barrier recovery was faster in females than in males in both control and lower-dose groups. In both males and females, barrier recovery was delayed with higher doses of sun exposure. In males, sun exposure did not alter SC hydration, while in females SC hydration was lower with lower doses of sun exposure as compared with control and higher doses of sun exposure. These results demonstrated that sun-induced changes in SC function and SC hydration vary with gender and the extent of sun exposure.

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“…The maximum erythema occurs 8-24 h after irradiation (125,126). As patients over 70 years show a prolonged nUVB-induced erythema, a more cautious approach to dose increases is recommended in the elderly (127).…”

Section: Early Side Effectsmentioning

confidence: 99%

Phototherapy with Narrowband vs Broadband UVB

Berneburg¹,

Röcken²,

Benedix³

2005

Acta Dermato-Venereologica

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Phototherapy with ultraviolet (UV) radiation of wavelengths between 280 and 320 nm (UVB) is a safe and effective treatment for a variety of diseases. In addition to standard broadband UVB (bUVB), narrowband phototherapy with fluorescent bulbs emitting near monochromatic UV around 311 nm (nUVB) has become an important treatment for diseases such as psoriasis, atopic dermatitis and vitiligo. In addition to these indications, the number of diseases for which nUVB phototherapy is reported to be effective is continuously growing. The differential effects of nUVB phototherapy in comparison to other UV wavelengths as well as established and new indications for this treatment modality are reviewed.

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Age dependence of ultraviolet light‐induced erythema following narrow‐band UVB exposure

Abstract: Narrow-band UVB therapy may, in case of over dosage, produce more intense erythema in the late phase of UVB erythema in old people than in younger individuals.

Cited by 28 publications

References 19 publications

Effects of Narrow Band UVB (311 nm) Irradiation on Epidermal Cells

Effects of Narrow Band UVB (311 nm) Irradiation on Epidermal Cells

Sun-Induced Changes in Stratum Corneum Function Are Gender and Dose Dependent in a Chinese Population

Phototherapy with Narrowband vs Broadband UVB

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