Age-Dependency of Cardiac and Neuromuscular Findings in Adults With Left Ventricular Hypertrabeculation/Noncompaction

Key Questions Relating to Left Ventricular Noncompaction Cardiomyopathy: Is the Emperor Still Wearing Any Clothes?

“…54 Stöllberger and colleagues, furthermore, showed that the presence of excessive trabeculations did not predict clinical outcomes in adults. 55 Further corroboration of these notions is now provided by the recent publications based, on the one hand, on a large cohort of healthy people, and on the other hand a prospective study of 113 individuals positive for "noncompaction". 31,35 How, then, should we assess individuals with excessive trabeculation?…”

Comment on “Ventricular non‐compaction cardiomyopathy: prenatal diagnosis and pathology”

“…What was the clinical indication? NMDs are associated with LVHT in up to 80% of the cases . In how many cases was the family history positive for NMD?…”

“…The higher prevalence of women in fetal LVHT cases is at variance with cohort studies from infants and adults in whom the prevalence of men is higher. 3,4 The cause for this phenomenon is, so far, unknown. Thus, it would be interesting to know the gender of the nine patients.…”

“…NMDs are associated with LVHT in up to 80% of the cases. 4 In how many cases was the family history positive for NMD? Did any of the fetuses develop decrease of movements during pregnancy?…”

Prevent Sudden Death in Carvajal Syndrome With Left Ventricular Hypertrabeculation/Noncompaction

“…Since LVHT is frequently associated with neuromuscular disorders it would be of interest to know if the patient was investigated neurologically and if she had a family history of a neuromuscular disorder ( 9 ).…”