Age‐dependency of glycosaminoglycan content in lumbar discs: A 3t gagcEST study

Müller‐Lutz, Anja; Schleich, Christoph; Pentang, Gael; Schmitt, Benjamin; Lanzman, Rotem S.; Matuschke, Felix; Wittsack, Hans‐Jörg; Miese, Falk

doi:10.1002/jmri.24945

Cited by 37 publications

(40 citation statements)

References 30 publications

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“…The residual signal normalized to the reference image as a function of the offset frequencies (z-spectrum) can be utilized for the evaluation of GAG CEST effect 17 . GagCEST values were determined using the MTR asym value in the frequency range from 0.9 to 1.9 ppm, which comprises the chemical exchange resonances of GAG hydroxyl protons 14 .…”

Section: Data Analysis and Measurementsmentioning

confidence: 99%

“…Data analysis methods and calculations of gagCEST measurements were used according the work of Müller-Lutz et al 17 For reliability assessment, the analysis was repeated by the latter and by a second observer (AML) (medical physicist with four years of segmenting experience in musculoskeletal imaging).…”

Section: Data Analysis and Measurementsmentioning

confidence: 99%

“…The detailed parameters of biochemical and morphological sequences were selected according to the study of Müller-Lutz et al (Table I) 17 .…”

Section: Mr Hardware Sequence Protocol and Gagcest Imagingmentioning

confidence: 99%

“…WASSR and CEST images were motion-corrected using a diffeomorphic image registration approach incorporated in the prototype software fMRLung (Siemens Healthcare, Erlangen, Germany) 20 . A reduction of image noise was performed using an in-plane 3 Â 3 Gaussian filter 17 . B0 field inhomogeneities were corrected using the WASSR maximum symmetry algorithm 21 .…”

Section: Data Analysis and Measurementsmentioning

confidence: 99%

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Facet tropism and facet joint orientation: risk factors for the development of early biochemical alterations of lumbar intervertebral discs

Schleich

Blum

Boos

et al. 2016

Osteoarthritis and Cartilage

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show abstract

Section: Data Analysis and Measurementsmentioning

confidence: 99%

Section: Data Analysis and Measurementsmentioning

confidence: 99%

“…The detailed parameters of biochemical and morphological sequences were selected according to the study of Müller-Lutz et al (Table I) 17 .…”

Section: Mr Hardware Sequence Protocol and Gagcest Imagingmentioning

confidence: 99%

Section: Data Analysis and Measurementsmentioning

confidence: 99%

See 2 more Smart Citations

Facet tropism and facet joint orientation: risk factors for the development of early biochemical alterations of lumbar intervertebral discs

Schleich

Blum

Boos

et al. 2016

Osteoarthritis and Cartilage

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show abstract

“…179,181 GagCEST has also been applied to study nondegenerative lumbar intervertebral discs 182 and may differentiate between the nucleus pulyposus (NP) and annulus fibrosus (AF) of these discs. [183][184][185][186] GagCEST technology, similar to the APTw approach, is based on MTR asym analysis and optimization of the process, especially with respect to the correction of B 0 and B 1 inhomogeneities and removal of interference by NOEs, is still ongoing. Applications to larger study cohorts are needed to convert this into a clinically viable technique.…”

Section: Glycosaminoglycan Cest (Gagcest)mentioning

confidence: 99%

Proton Chemical Exchange Saturation Transfer (CEST) MRS and MRI

Zijl

Sehgal

2016

eMagRes

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Proton magnetic resonance spectroscopy ( 1 H MRS) of biological systems has higher specificity than MRI because resonances of multiple metabolites can be distinguished, reflecting chemistry and physiology in situ. Unfortunately, this approach has very low sensitivity as the metabolites are typically at millimolar concentrations compared to the molar signal strength of water-based MRI. As a consequence, even though 1 H MRS is a powerful and common research tool, its inroad into daily clinical practice has been limited. Until very recently, 1 H MRS applications have focused on the resonances upfield (i.e., at lower frequency) of the water resonance. This article deals with protons that are generally not observed in a typical water-suppressed spectrum, namely, the exchangeable protons found predominantly downfield from water. These can usually be detected by MRS only if the transfer of water proton saturation (established during water suppression) is not a confounding factor, or by using water exchange (WEX) spectroscopy, in which RF labeling of the water protons is transferred to the exchangeable protons and subsequently detected. More importantly, it has recently become clear that the presence of such exchangeable protons on low concentration solute molecules can be detected via the water signal by RF labeling of these protons and subsequent transfer of this label to water protons. This process, leading to saturation of the water signal and enhancement of the effect through repeated exchange, can be used for the imaging of metabolite signals or exchangeable-proton-based contrast agents with enhanced sensitivity. This has given rise to the field of chemical exchange saturation transfer (CEST) MRI, which has greatly increased the potential for translating spectroscopic methods to the clinic. Examples include the measurement of pH, temperature, and enzyme activity as well as detection of cellular metabolites, ions, and proteins and peptides. In addition, bio-organic compounds can now be used for contrast agents, cell and nanoparticle labeling, and reporter genes.

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Progress toward quantitative in vivo chemical exchange saturation transfer (CEST) MRI

Zhou

Qiu

et al. 2017

Israel Journal of Chemistry

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Chemical exchange saturation transfer (CEST) MRI provides a sensitive detection mechanism for imaging dilute labile protons, complementing the routine radiological exams. Enormous progress has been achieved in CEST MRI and image analysis, from the mathematical modeling, CEST agent design, and most importantly, increasing adoption of CEST imaging in the clinical setting. Therefore, CEST imaging represents an emerging field that involves multiple disciplines and together made a remarkable transition from the simplistic CEST‐weighted MRI to quantitative CEST (qCEST) analysis. This review focuses on the recent advancements in CEST quantification techniques and findings of in vivo CEST imaging in representative disorders of ischemia, tumor, and epilepsy. In addition, limitations of current CEST methodologies are examined that should help guide future development of more sensitive and quantitative CEST imaging techniques and ultimately, facilitate their adoption in the clinical setting.

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Age‐dependency of glycosaminoglycan content in lumbar discs: A 3t gagcEST study

Abstract: We show a decreased gagCEST effect likely corresponding to decreasing glycosaminoglycans with aging. Hence, age-matched analysis of gagCEST imaging may be necessary in future studies.

Cited by 37 publications

References 30 publications

Facet tropism and facet joint orientation: risk factors for the development of early biochemical alterations of lumbar intervertebral discs

Facet tropism and facet joint orientation: risk factors for the development of early biochemical alterations of lumbar intervertebral discs

Proton Chemical Exchange Saturation Transfer (CEST) MRS and MRI

Progress toward quantitative in vivo chemical exchange saturation transfer (CEST) MRI

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