Age-dependent amplitude variation of brain-stem auditory evoked potentials

Psatta, D; Matei, M

doi:10.1016/0168-5597(88)90016-0

Cited by 42 publications

(24 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most, if not all, studies of the effects of aging on ABR amplitudes in humans demonstrate reductions in amplitudes as a function of age (Beagley & Sheldrake, 1978;Costa, Benna, Bianco, Ferrero, & Bergamasco, 1990;Harkins, 1981;Kjaer, 1980;Psatta & Matei, 1988;Sand, 1991). Even when threshold elevation is accounted for, most studies suggest a reduction in ABR amplitudes in older participants.…”

Section: Presbyacusis and Abr Amplitudesmentioning

confidence: 99%

See 1 more Smart Citation

Presbyacusis and the Auditory Brainstem Response

Boettcher

2002

J Speech Lang Hear Res

View full text Add to dashboard Cite

Age-related hearing loss (ARHL or presbyacusis) is an increasingly common form of sensorineural hearing loss (SNHL) as a result of changing demographics, and the auditory brainstem response (ABR) is a common experimental and clinical tool in audiology and neurology. Some of the changes that occur in the aging auditory system may significantly influence the interpretation of the ABR in comparison to the ABRs of younger adults. The approach of this review will be to integrate physiological and histopathological data from human and animal studies to provide a better understanding of the array of age-related changes in the ABR and to determine how age-related changes in the auditory system may influence how the ABR should be interpreted in presbyacusis. Data will be described in terms of thresholds, latencies, and amplitudes, as well as more complex auditory functions such as masking and temporal processing. Included in the review of data will be an attempt to differentiate between age-related effects that may strictly be due to threshold elevation from those that may be due to the aging process.

show abstract

Section: Presbyacusis and Abr Amplitudesmentioning

confidence: 99%

“…Even when threshold elevation is accounted for, most studies suggest a reduction in ABR amplitudes in older participants. Typically, the amplitude of Wave I or the electrocochleogram is more affected by age than Wave V (Costa et al, 1990;Psatta & Matei, 1988;Sand, 1990).…”

Section: Presbyacusis and Abr Amplitudesmentioning

confidence: 99%

Presbyacusis and the Auditory Brainstem Response

Boettcher

2002

J Speech Lang Hear Res

View full text Add to dashboard Cite

show abstract

“…Compared with interpeak intervals, the amplitudes of BAER components are less commonly used BAER variables due to a relatively large across subject variability [9,10,29]. However, more recent studies have shown that under well-controlled and consistent experimental conditions the amplitudes of BAER waves, mainly wave V, are useful variables in reflecting central auditory function and functional status of the brainstem [10,15,16,30,31].…”

Section: Introductionmentioning

confidence: 98%

Depressed brainstem auditory electrophysiology in preterm infants after perinatal hypoxia–ischaemia

Jiang

Brosi

Wilkinson

2009

Journal of the Neurological Sciences

View full text Add to dashboard Cite

“…Decreases in ABR amplitude with advanced age are frequently reported, with slight changes also found for latency and interpeak intervals (IPIs) though not always in a consistent pattern (Rowe, 1978; Jerger and Hall, 1980; Maurizi et al, 1982; Allison et al, 1983; Debruyne, 1986; Costa et al, 1990). When results for early peaks are reported, the amplitude of wave I or the auditory nerve compound action potential (CAP) is typically more affected by age compared to wave V (Psatta and Matei, 1988; Costa et al, 1990; Sand, 1991; Burkard and Sims, 2001). …”

mentioning

confidence: 99%

Age-Related Changes in the Auditory Brainstem Response

Konrad-Martin¹,

Dille²,

McMillan³

et al. 2012

J Am Acad Audiol

138

103

View full text Add to dashboard Cite

Purpose This cross-sectional study had two goals: (1) Identify and quantify the effects of aging on the auditory brainstem response (ABR); (2) Describe how click rate and hearing impairment modify effects of aging. Research Design and Analysis ABR measures were obtained from 131 predominately male Veteran participants aged 26 to 71 yr. Metrics analyzed include amplitude and latency for waves I, III, and V, and the I–V interpeak latency interval (IPI) at three repetition rates (11, 51, and 71 clicks/sec) using both polarities. In order to avoid confounding from missing data due to hearing impairment, participants had hearing thresholds <40 dB HL at 2 kHz and 70 dB HL at 4 kHz in at least one ear. Additionally, the median 2, 3, and 4 kHz pure tone threshold average (PTA2,3,4) for the sample, ~17 dB HL, was used to delineate subgroups of better and worse hearing ears, and only the better hearing sample was modeled statistically. We modeled ABR responses using age, repetition rate, and PTA2,3,4 as covariates. Random effects were used to model correlation between the two ears of a subject and across repetition rates. Inferences regarding effects of aging on ABR measures at each rate were derived from the fitted model. Results were compared to data from subjects with poorer hearing. Results Aging substantially diminished amplitudes of all of the principal ABR peaks, largely independent of any threshold differences within the group. For waves I and III, age-related amplitude decrements were greatest at a low (11/sec) click rate. At the 11/sec rate, the model-based mean wave III amplitude was significantly smaller in older compared with younger subjects even after adjusting for wave I amplitude. Aging also increased ABR peak latencies, with significant shifts limited to early waves. The I–V IPI did not change with age. For both younger and older subjects, increasing click presentation rate significantly decreased amplitudes of early peaks and prolonged latencies of later peaks, resulting in increased IPIs. Advanced age did not enhance effects of rate. Instead, the rate effect on wave I and III amplitudes was attenuated for the older subjects due to reduced peak amplitudes at lower click rates. Compared with model predictions from the sample of better hearing subjects, mean ABR amplitudes were diminished in the group with poorer hearing, and wave V latencies were prolonged. Conclusions In a sample of veterans, aging substantially reduced amplitudes of all principal ABR peaks, with significant latency shifts limited to waves I and III. Aging did not influence the I–V IPI even at high click rates, suggesting that the observed absolute latency changes associated with aging can be attributed to changes in auditory nerve input. In contrast, ABR amplitude changes with age are not adequately explained by changes in wave I. Results suggest that aging reduces the numbers and/or synchrony of contributing auditory nerve units. Results also support the concept that aging reduces the numbers, though perhaps not the synchrony, ...

show abstract

Age-dependent amplitude variation of brain-stem auditory evoked potentials

Cited by 42 publications

References 17 publications

Presbyacusis and the Auditory Brainstem Response

Presbyacusis and the Auditory Brainstem Response

Depressed brainstem auditory electrophysiology in preterm infants after perinatal hypoxia–ischaemia

Age-Related Changes in the Auditory Brainstem Response

Contact Info

Product

Resources

About