Age-dependent association between cigarette smoking on white matter hyperintensities

Kim, Sung Hun; Yun, Chang-Ho; Lee, Seo-Young; Choi, Kyung-Ho; Kim, Min Bom; Park, Hee-Kwon

doi:10.1007/s10072-011-0617-1

Cited by 22 publications

(17 citation statements)

References 41 publications

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“…Short-term tobacco smoking is associated with elevation in FA (57, 58), while long-term smoking leads to decline in FA (59, 60). We re-analyzed our data only in non-smoker SCZ vs. non-smoker controls, and found that SCZ patients still experienced higher rates of age-related decline than normal controls (β age*scz = −0.0015±0.0006, t=1.8; p=0.06).…”

Section: Discussionmentioning

confidence: 97%

Testing the Hypothesis of Accelerated Cerebral White Matter Aging in Schizophrenia and Major Depression

Kochunov

Glahn

Rowland

et al. 2013

Biological Psychiatry

112

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Introduction Elevated rate of aging-related biological and functional decline, termed accelerated aging, is reported in patients with schizophrenia (SCZ) and major depressive disorder (MDD). We used diffusion tensor imaging (DTI) derived fractional anisotropy (FA) as biomarkers of aging-related decline in white matter (WM) integrity to test the hypotheses of accelerated aging in SCZ and MDD. Methods The SCZ cohort was composed of 58/60 SCZ patients/controls (age=20–60years). MDD cohort was composed of 136/351 MDD patients/controls (age=20–79years). Main outcome measures were the diagnosis-by-age interaction on whole-brain-averaged WM FA values and FA values from twelve major WM tracts. Results Diagnosis-by-age interaction for the whole-brain average FA was significant for the SCZ (p=0.04) but not in MDD cohort (p=0.80). Diagnosis-by-age interaction was nominally significant (p<0.05) for five WM tracts for SCZ and for none of the tracts in the MDD cohort. Tract-specific heterochronicity of the onset of age-related decline in SCZ demonstrated strong negative correlations with the age-of- peak myelination and the rates of age-related decline obtained from normative sample (r=−0.61 and −0.80, p<0.05, respectively). No such trends existed for MDD cohort. Conclusion Cerebral WM showed accelerated aging in SCZ but not in MDD, suggesting some difference in the pathophysiology underlying their WM aging changes. Tract-specific heterochronicity of WM development modulated presentation of accelerated aging in SCZ: white matter tracts that matured later in life appeared more sensitive to the pathophysiology of SCZ and demonstrated more susceptibility to disorder-related accelerated decline in FA values with age. This trend was not observed in MDD cohort.

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Section: Discussionmentioning

confidence: 97%

Testing the Hypothesis of Accelerated Cerebral White Matter Aging in Schizophrenia and Major Depression

Kochunov

Glahn

Rowland

et al. 2013

Biological Psychiatry

112

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“…Cerebrovascular risk factors are associated with development of cerebrovascular changes, which increases with increasing age. An age-dependent association between smoking and white matter hyperintensities is found [33]. Our patients population is relatively young, something which may explain the lack of association between cognitive impairment and risk factors.…”

Section: Discussionmentioning

confidence: 99%

Cognitive and Emotional Impairment after Minor Stroke and Non-ST-Elevation Myocardial Infarction (NSTEMI): A Prevalence Study

Morsund

Ellekjær

Gramstad

et al. 2019

Stroke Research and Treatment

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Aim. To study the prevalence of cognitive and emotional impairment following a minor ischemic stroke compared to an age-matched group with non-ST-elevation myocardial infarction (NSTEMI). Methods. We included patients aged 18-70 years with a minor ischemic stroke defined as modified Rankin Scale (mRS) 0-2 at day 7 or at discharge if before and age-matched NSTEMI patients with the same functional mRS. We applied a selection of cognitive tests and the patients completed a questionnaire comprising of Hospital Anxiety and Depression scale (HADS) and Fatigue Severity Scale (FSS) at follow-up 12 months after the vascular event. Results of cognitive tests were also compared to normative data. Results. 325 ischemic stroke and 144 NSTEMI patients were included. There was no significant difference in cognitive functioning between ischemic stroke and NSTEMI patients. Minor stroke patients and to a lesser extent NSTEMI patients scored worse on more complex cognitive functions including planning and implementation of activities compared to validated normative data. For the minor stroke patients the location of the ischemic lesion had no influence on the result. The prevalence of anxiety, depression, and fatigue was significantly higher in the stroke group compared to the NSTEMI group. Depression was independently associated with reduced cognitive function. Discussion and Conclusion. Minor ischemic stroke patients, and to lesser degree NSTEMI patients, had reduced cognitive function compared to normative data, especially executive functioning, on 12-month follow-up. The difference in cognitive function between stroke and NSTEMI patients was not significant. Depression was associated with low scores on cognitive tests highlighting the need to adequately address emotional sequelae when considering treatment options for cognitive disabilities.

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“…Ascertainment of a large antipsychotic-naive SZ patient group is important, across different ages, to rule out interactions between medication effects and aging. Smoking is another possible contributing or confounding factor, because long-term smoking leads to decline in FA (Gons, et al 2011; Kim, et al 2010). Here, we observed no significant mega-analytical effect of smoking status on the whole-brain average FA values.…”

Section: Discussionmentioning

confidence: 99%

Heterochronicity of white matter development and aging explains regional patient control differences in schizophrenia

Kochunov

Ganjgahi

Winkler

et al. 2016

Human Brain Mapping

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Background Altered brain connectivity is implicated in the development and clinical burden of schizophrenia. Relative to matched controls, schizophrenia patients show (1) a global and regional reduction in the integrity of the brain’s white matter (WM), assessed using diffusion tensor imaging (DTI) fractional anisotropy (FA), and (2) accelerated age-related decline in FA values. In the largest mega-analysis to date, we tested if differences in the trajectories of WM tract development influenced patient-control differences in FA. We also assessed if specific tracts showed exacerbated decline with aging. Methods Three cohorts of schizophrenia patients (total n=177) and controls (total n=249; age=18–61 years) were ascertained with three 3T Siemens MRI scanners. Whole-brain and regional FA values were extracted using ENIGMA-DTI protocols. Statistics were evaluated using mega- and meta-analyses to detect effects of diagnosis and age-by-diagnosis interactions. Results In mega-analysis of whole-brain averaged FA, schizophrenia patients had lower FA (p=10−11) and faster age-related decline in FA (p=0.02) compared to controls. Tract-specific heterochronicity measures, i.e., abnormal rates of adolescent maturation and aging explained ~50% of the regional variance effects of diagnosis and age-by-diagnosis interaction in patients. Interactive, 3D visualization of the results is available at www.enigma-viewer.org. Conclusion WM tracts that mature later in life appeared more sensitive to the pathophysiology of schizophrenia and were more susceptible to faster age-related decline in FA values.

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Age-dependent association between cigarette smoking on white matter hyperintensities

Cited by 22 publications

References 41 publications

Testing the Hypothesis of Accelerated Cerebral White Matter Aging in Schizophrenia and Major Depression

Testing the Hypothesis of Accelerated Cerebral White Matter Aging in Schizophrenia and Major Depression

Cognitive and Emotional Impairment after Minor Stroke and Non-ST-Elevation Myocardial Infarction (NSTEMI): A Prevalence Study

Heterochronicity of white matter development and aging explains regional patient control differences in schizophrenia

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