Age-dependent associations among insomnia, depression, and inflammation in nurses

Walker, Jamie; Slavish, Danica C.; Dolan, Megan; Dietch, Jessica R.; Wardle‐Pinkston, Sophie; Messman, Brett; Ruggero, Camilo J.; Kohut, Marian L.; Borwick, Joshua; Kelly, Kenneth; Taylor, Daniel J.

doi:10.1080/08870446.2020.1805450

Cited by 13 publications

(10 citation statements)

References 76 publications

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“…[17][18][19][20] However, several other studies have shown no associations of insomnia with TNF-α and IL-1β. 21,22 In brief, previous studies on insomnia and inflammation have predominantly focused on CRP, IL-6, TNF-α, and IL-1β, with slightly varying findings. These varying findings may be a result of inconsistent assessment of insomnia symptoms and different age group compositions.…”

Section: Introductionmentioning

confidence: 99%

Relationships Between a Range of Inflammatory Biomarkers and Subjective Sleep Quality in Chronic Insomnia Patients: A Clinical Study

Xia¹,

Zhang²,

Niu³

et al. 2021

NSS

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Purpose To examine whether associations exist between chronic insomnia disorder (CID) and overlooked inflammatory factors (Serum amyloid protein A [SAA]), tumor necrosis factor [TNF]-α, granulocyte-macrophage colony-stimulating factor [GM-CSF], and regulated on activation and normal T cell expressed and presumably secreted [RANTES]). Patients and Methods A total of 65 CID patients and 39 sex- and age-matched good sleeper (GS) controls participated in this study. They completed a baseline survey to collect data on demographics, and were elevated sleep and mood by Pittsburgh Sleep Quality Index (PSQI), Athens Insomnia Scale (AIS), 17-item Hamilton Depression Rating Scale (HAMD-17) and 14-item Hamilton Anxiety Rating Scale (HAMA-14), respectively. The blood samples were collected and tested the serum levels of SAA, TNF-α, GM-CSF and RANTES. Results The CID group had higher serum levels of SAA, TNF-α, and GM-CSF and a lower level of RANTES than the GS group. In the Spearman correlation analysis, SAA and GM-CSF positively correlated with the PSQI and AIS scores. After controlling for sex, HAMD-17 score, and HAMA-14 score, the partial correlation analysis showed that GM-CSF was positively correlated with PSQI score. Further stepwise linear regression analyses showed that GM-CSF was positively associated with the PSQI and AIS scores, while RANTES was negatively associated with them, and SAA was positively associated with just the AIS score. Conclusion The serum levels of inflammatory mediators (SAA, TNF-α, and GM-CSF) were significantly elevated and the level of RANTES was significantly decreased in CID patients and, to some extent, the changes are related to the severity of insomnia. These findings may help us to improve interventions to prevent the biological consequences of CID by inhibiting inflammation, thereby promoting health.

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Section: Introductionmentioning

confidence: 99%

Relationships Between a Range of Inflammatory Biomarkers and Subjective Sleep Quality in Chronic Insomnia Patients: A Clinical Study

Xia¹,

Zhang²,

Niu³

et al. 2021

NSS

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“…It is well known that chronic inflammation is evaluated by the combined secretion of pro‐inflammatory markers (e.g., CRP, TNF‐α, IL‐1β, IL‐6) and anti‐inflammatory cytokines (e.g., IL‐10) (Boshtam et al, 2017). There is compelling evidence that insomnia may be associated with the development of chronic inflammation; however, no fully consistent conclusions have been drawn (Dolsen et al, 2021; Syauqy et al, 2019; Walker et al, 2021). Most studies have established links between insomnia symptoms and elevated levels of chronic inflammation, which is consistent with our findings (Fernandez‐Mendoza et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…This may suggest that these risk factors can intervene in the association with insomnia and chronic inflammation. Adolescents with symptoms of insomnia are more likely to engage in risky health behaviours, such as smoking and drinking alcohol, as well as to struggle with depression (Walker et al, 2021; Zagaria et al, 2022). Future studies are warranted to examine these stratifications in general population samples, as well as to provide useful information for preventive interventions.…”

Section: Discussionmentioning

confidence: 99%

“…Limited evidence suggested that elevated levels of IL‐6 and CRP were found in adults with symptoms of insomnia, but most studies have not yet explored changes in insomnia using trajectory models (Dolsen et al, 2021; Syauqy et al, 2019). Conversely, another study reported there was no relationship between insomnia and inflammation (Walker et al, 2021). Therefore, this study aimed to fill in the gaps in the predictive effects of insomnia trajectories on inflammation during the transition to adulthood.…”

Section: Introductionmentioning

confidence: 99%

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Insomnia trajectories predict chronic inflammation over 2 years at the transition to adulthood

Zhai

Zhang

et al. 2023

Journal of Sleep Research

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SummaryInsomnia in adolescents is an important public health concern, as its impacts on both their current and future physical and mental health has been discussed. However, few longitudinal studies have examined insomnia and chronic inflammation at the transition from adolescence to adulthood. This study aimed to examine the predictive effects of insomnia and insomnia trajectories on inflammation in college students by using a prospective design. Using data from the College Student Behaviour and Health Cohort Study, which was conducted between April 2019 and April 2021, with an interval of 6 months. We investigated the associations between insomnia trajectories from Year 1 to Year 3 and five inflammatory biomarkers (C‐reactive protein [CRP], tumour necrosis factor [TNF]‐α, interleukin [IL]‐6, IL‐1β, IL‐10) at Year 3. The association of insomnia symptoms at baseline, Wave 1 or Wave 2 with inflammatory biomarkers at Wave 4 were also assessed. A total of 312 college students (males: 51.6%) aged 16–26 years (mean [SD] 18.82 [1.22] years) were analysed. We identified two insomnia trajectory classes: increasing insomnia (n = 63 [20.2%]) and decreasing insomnia (n = 249 [79.8%]). Generalised linear model analysis revealed that insomnia symptoms at Wave 1 were associated with significantly elevated CRP and TNF‐α levels at Wave 4. Increasing insomnia trajectories predicted consistently higher levels of CRP, TNF‐α and IL‐10. However, after adjusting for potential confounders, these associations were significantly attenuated. Overall, the findings suggest that insomnia symptoms affect chronic inflammation at the transition to adulthood. Our study needs to be replicated in larger cohorts to further explore how inflammation interacts with insomnia to increase the susceptibility to adverse health conditions.

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“…For example, IL-6 is instrumental in CRP and fibrinogen production, and inhibiting IL-6 with monoclonal antibodies affects lipid markers (Raison, Knight, & Pariante, 2018). Also, although controlling for age did not affect the results in this middle-aged sample, network associations might be more potent in middle-aged compared to younger adult women (Walker et al, 2021). Nonetheless, study strengths include the large sample size and the cutting-edge CLPN that separated within-and between-person relations and offered more information than traditional statistics.…”

Section: Discussionmentioning

confidence: 99%

Prospective network analysis of proinflammatory proteins, lipid markers, and depression components in midlife community women

Zainal

Newman

2022

Psychol. Med.

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Background Vulnerability theories propose that suboptimal levels of lipid markers and proinflammatory proteins predict future heightened depression. Scar models posit the reverse association. However, most studies that tested relationships between non-specific immune/endocrine markers and depression did not separate temporal inferences between people and within-person and how different immunometabolism markers related to unique depression symptoms. We thus used cross-lagged prospective network analyses (CLPN) to investigate this topic. Methods Community midlife women (n = 2224) completed the Center for Epidemiologic Studies-Depression scale and provided biomarker samples across five time-points spanning 9 years. CLPN identified significant relations (edges) among components (nodes) of depression (depressed mood, somatic symptoms, interpersonal issues), lipid markers [insulin, fasting glucose, triglycerides, low-density lipoprotein-cholesterol (LDL), high-density lipoprotein-cholesterol (HDL)], and proinflammatory proteins [C-reactive protein (CRP), fibrinogen], within and across time-points. All models adjusted for age, estradiol, follicle-stimulating hormone, and menopausal status. Results In within-person temporal networks, higher CRP and HDL predicted all three depression components (d = 0.131–2.112). Increased LDL preceded higher depressed mood and interpersonal issues (v. somatic symptoms) (d = 0.251–0.327). Elevated triglycerides predicted more somatic symptoms (v. depressed mood and interpersonal problems) (d = 0.131). More interpersonal problems forecasted elevated fibrinogen and LDL levels (d = 0.129–0.331), and stronger somatic symptoms preceded higher fibrinogen levels (d = 0.188). Conclusions Results supported both vulnerability and scar models. Long-term dysregulated immunometabolism systems, social disengagement, and related patterns are possible mechanistic accounts. Cognitive-behavioral therapies that optimize nutrition and physical activity may effectively target depression.

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Age-dependent associations among insomnia, depression, and inflammation in nurses

Cited by 13 publications

References 76 publications

Relationships Between a Range of Inflammatory Biomarkers and Subjective Sleep Quality in Chronic Insomnia Patients: A Clinical Study

Relationships Between a Range of Inflammatory Biomarkers and Subjective Sleep Quality in Chronic Insomnia Patients: A Clinical Study

Insomnia trajectories predict chronic inflammation over 2 years at the transition to adulthood

Prospective network analysis of proinflammatory proteins, lipid markers, and depression components in midlife community women

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