Age-dependent change of serum 5.ALPHA.-dihydrotestosterone and its relation to testosterone in man.

Nawata, Hajime; Kato, Kanefusa; Itoh, Hiroshi

doi:10.1507/endocrj1954.24.41

Cited by 9 publications

(2 citation statements)

References 7 publications

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“…Mean serum testosterone values also decline in man, but this appears to occur late in life after the age of 60 yr (24,25). Nawata et al (26) reported a similar decline in DHT in aging men, but Pirke and Doerr (27) have reported that serum levels of DHT are unchanged with age.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous benign prostatic hyperplasia in the beagle. Age-associated changes in serum hormone levels, and the morphology and secretory function of the canine prostate.

et al. 1983

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A B S T R A C T This paper is a cross-sectional study of spontaneous benign prostatic hyperplasia (BPH) in a single canine species. The effects of aging and hormonal changes on the growth, histology, and glandular secretory function of the canine prostate were studied in 42 male beagles ranging in age from 8 mo to 9 yr. The beagle prostate enlarges for at least 6 yr, whether normal or hyperplastic. In contrast, prostatic secretory function, determined by ejaculate volume and total ejaculate protein, declines markedly after 4 yr of age. These reciprocal growth and functional changes in the prostate are closely associated with a progressive increase in the incidence of BPH, which is already apparent in some dogs by age two. With age there is a modest decrease in serum androgen levels with no apparent change in serum 17,3-estradiol levels. This suggests that the growth and functional changes that are associated with the development of BPH and are initiated very early in life reflect an altered sensitivity of the prostate to serum androgens or a response to the relative decrease in the serum androgen to estrogen ratio.

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Section: Discussionmentioning

confidence: 99%

Spontaneous benign prostatic hyperplasia in the beagle. Age-associated changes in serum hormone levels, and the morphology and secretory function of the canine prostate.

et al. 1983

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“…These results firmly support the important role of AR-CAND1 axis in NAFLD development. Testosterone level is high in adolescence and markedly decrease in old age 46 , 47 . We found that androgen receptor was increased at the age of 6-month and declined at the age of 12-month in mice.…”

Section: Discussionmentioning

confidence: 99%

Cullin-associated and neddylation-dissociated protein 1 (CAND1) alleviates NAFLD by reducing ubiquitinated degradation of ACAA2

Huang,

Liu,

et al. 2023

Nat Commun

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Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder with high morbidity and mortality. The current study aims to explore the role of Cullin-associated and neddylation-dissociated protein 1 (CAND1) in the development of NAFLD and the underlying mechanisms. CAND1 is reduced in the liver of NAFLD male patients and high fat diet (HFD)-fed male mice. CAND1 alleviates palmitate (PA) induced lipid accumulation in vitro. Hepatocyte-specific knockout of CAND1 exacerbates HFD-induced liver injury in HFD-fed male mice, while hepatocyte-specific knockin of CAND1 ameliorates these pathological changes. Mechanistically, deficiency of CAND1 enhances the assembly of Cullin1, F-box only protein 42 (FBXO42) and acetyl-CoA acyltransferase 2 (ACAA2) complexes, and thus promotes the ubiquitinated degradation of ACAA2. ACAA2 overexpression abolishes the exacerbated effects of CAND1 deficiency on NAFLD. Additionally, androgen receptor binds to the −187 to −2000 promoter region of CAND1. Collectively, CAND1 mitigates NAFLD by inhibiting Cullin1/FBXO42 mediated ACAA2 degradation.

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Radioimmunoassay of 5-androstene-3β,17β-diol in plasma and in breast cyst fluid

Nahoul¹,

Bournique²,

Adeline³

et al. 1986

Journal of Steroid Biochemistry

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Age-dependent change of serum 5.ALPHA.-dihydrotestosterone and its relation to testosterone in man.

Cited by 9 publications

References 7 publications

Spontaneous benign prostatic hyperplasia in the beagle. Age-associated changes in serum hormone levels, and the morphology and secretory function of the canine prostate.

Spontaneous benign prostatic hyperplasia in the beagle. Age-associated changes in serum hormone levels, and the morphology and secretory function of the canine prostate.

Cullin-associated and neddylation-dissociated protein 1 (CAND1) alleviates NAFLD by reducing ubiquitinated degradation of ACAA2

Radioimmunoassay of 5-androstene-3β,17β-diol in plasma and in breast cyst fluid

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