2018
DOI: 10.1136/gutjnl-2017-315542
|View full text |Cite
|
Sign up to set email alerts
|

Age-dependent changes in GI physiology and microbiota: time to reconsider?

Abstract: Our life expectancy is increasing, leading to a rise in the ageing population. Ageing is associated with a decline in physiological function and adaptive capacity. Altered GI physiology can affect the amount and types of nutrients digested and absorbed as well as impact the intestinal microbiota. The intestinal microbiota is considered a key player in our health, and a variety of studies have reported that microbiota composition is changing during ageing. Since ageing is associated with a decline in GI functio… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

9
146
0

Year Published

2019
2019
2022
2022

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 171 publications
(155 citation statements)
references
References 93 publications
9
146
0
Order By: Relevance
“…For example, the abundance of Bifidobacteria in the fecal microbiota was reduced in elderly, and it has been found by many studies . The abundance of Lactobacilli was found to increase or not differ from young adult and elderly cohort, and the alterations are more likely to be associated with health status rather than with chronological aging per se . The altered composition of gut microbiota was also found to play a central role in systemic inflammation during the aging process due to its ability to release inflammatory products .…”
Section: Introductionmentioning
confidence: 82%
See 1 more Smart Citation
“…For example, the abundance of Bifidobacteria in the fecal microbiota was reduced in elderly, and it has been found by many studies . The abundance of Lactobacilli was found to increase or not differ from young adult and elderly cohort, and the alterations are more likely to be associated with health status rather than with chronological aging per se . The altered composition of gut microbiota was also found to play a central role in systemic inflammation during the aging process due to its ability to release inflammatory products .…”
Section: Introductionmentioning
confidence: 82%
“…Generally, the diversity of gut microbiota and the carriage of commensals are found to be reduced while the levels of opportunists are increased in elderly . For example, the abundance of Bifidobacteria in the fecal microbiota was reduced in elderly, and it has been found by many studies . The abundance of Lactobacilli was found to increase or not differ from young adult and elderly cohort, and the alterations are more likely to be associated with health status rather than with chronological aging per se .…”
Section: Introductionmentioning
confidence: 91%
“…It will be necessary to devise new dietary intervention studies to fully understand and elucidate the clinical relevance of these modifications. Specifically, it should be important to establish if a controlled variation on the dietary habits of aged individuals could positively impact their gut microbiota composition in a context of global ageing population .…”
Section: The Gut Microbiota Systemmentioning
confidence: 99%
“…The intestinal microbial ecosystem of older people is in fact commonly characterized by a reduction in biodiversity (an accepted hallmark of a healthy gut), enrichment in opportunistic pathogens (e.g., enterobacteria) and a decrease in saccharolytic bacteria from the Lachnospiraceae and Ruminococcaceae families, capable of producing short-chain fatty acids (SCFAs), particularly butyrate [5]. Given the multifaceted role of SCFAs in human physiology (e.g., maintenance of epithelial barrier integrity, metabolic regulation, immune functioning and modulation of neuronal activity) [6], this aged-type microbiota profile is supposed to variously contribute to the age-related functional decline, supporting inflammaging (i.e., the low-grade chronic inflammation characterizing the advancement of age) [7] and thus contributing to the pathophysiology of inflammation-related diseases frequently observed in the elderly [8][9][10][11].…”
Section: Introductionmentioning
confidence: 99%