2024
DOI: 10.3390/antiox13020206
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Age-Dependent Changes in Nrf2/Keap1 and Target Antioxidant Protein Expression Correlate to Lipoxidative Adducts, and Are Modulated by Dietary N-3 LCPUFA in the Hippocampus of Mice

Mario Díaz,
Catalina Valdés-Baizabal,
Daniel Pereda de Pablo
et al.

Abstract: The brain has a high metabolism rate that may generate reactive oxygen and nitrogen species. Consequently, nerve cells require highly efficient antioxidant defenses in order to prevent a condition of deleterious oxidative stress. This is particularly relevant in the hippocampus, a highly complex cerebral area involved in processing superior cognitive functions. Most current evidence points to hippocampal oxidative damage as a causal effect for neurodegenerative disorders, especially Alzheimer’s disease. Nuclea… Show more

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Cited by 3 publications
(2 citation statements)
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“…Estimation of membrane viscosity (in reciprocity to fluidity) from lipid profiles was performed following the statistical approaches reported for mouse brains [ 70 , 72 ]. A predictive multivariable function based on multiple regression analyses, which integrates the contributions of the phospholipid-to-cholesterol ratio, unsaturation-index-to-saturates ratio, average carbon chain length, and anionic-to-zwitterionic-phospholipids ratio were found to accurately predict membrane microviscosity (R 2 = 0.68, p < 0.005) [ 73 ].…”
Section: Resultsmentioning
confidence: 99%
“…Estimation of membrane viscosity (in reciprocity to fluidity) from lipid profiles was performed following the statistical approaches reported for mouse brains [ 70 , 72 ]. A predictive multivariable function based on multiple regression analyses, which integrates the contributions of the phospholipid-to-cholesterol ratio, unsaturation-index-to-saturates ratio, average carbon chain length, and anionic-to-zwitterionic-phospholipids ratio were found to accurately predict membrane microviscosity (R 2 = 0.68, p < 0.005) [ 73 ].…”
Section: Resultsmentioning
confidence: 99%
“…The Nrf2 protein serves as a vital transcription factor essential for preserving the integrity of redox signaling when cells face oxidative stress [10,11]. As a member of the cap'n'collar basic leucine zipper transcription factor family, Nrf2 plays a vital role in coordinating antioxidant and detoxification responses by upregulating downstream genes [12][13][14]. Under normal conditions, Nrf2 predominantly resides in the cytoplasm, forming a complex with its inhibitory partner, Kelch-like ECH-associated protein 1 (Keap1).…”
Section: Introductionmentioning
confidence: 99%