Age-dependent changes in some aspects of glutamate metabolism in the brain of the teleost, channa punctatus. I. Ammonia and glutamine contents and glutamate dehydrogenase activity

Mahapatro, Nibedita; Patnaik, B.K.

doi:10.1016/0047-6374(93)90139-i

Cited by 6 publications

(2 citation statements)

References 32 publications

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“…In brain a similar age-related trend was reported (table 3) [69], But in muscle the same parameter showed a continuous decline with age (correlation coef ficient r = -0.49, p < 0.001) [84], An increase in globulin antibodies with advancing age was observed in C. clupeafonnis [85]. Following age changes in glutamate metabolism, Mahapatro and Patnaik [86] observed an increased accumulation of ammonia and glutamine in the brain of the ageing murrel ( fig. 2, 3).…”

Section: Protein Metabolismsupporting

confidence: 55%

Ageing in Fishes

1994

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Fishes show three types of senescence. Lampreys, eels and pacific salmon exhibit rapid senescence and sudden death at first spawning. The guppy, red panchax, medaka, platyfish, Indian murrel and many other teleosts undergo gradual senescence, as observed in most of the vertebrates. A number of fishes (e.g. sturgeons, paddlefish, female plaice, flatfish, rock-fish) show indeterminate growth, the occurrence of senescence in them is supposed to be very slow or negligible. Neuroendo-crine mechanisms are involved in rapid senescence. Most of the evidences in favour of the occurrence of senescence in fishes have been derived from studies in species showing gradual senescence. Age-related increases in mortality rate, accumulation of lipofuscin, lipid peroxidation, collagen cross-linking and decreases in growth rate, reproductive capacity and protein utilisation are clearly marked in such species. Anatomical changes in various organs during ageing also confirm increases in degenerative changes and pathological symptoms. Dietary restriction and lower environmental temperature retard the ageing processes in a few species showing gradual senescence. These results tentatively support the contention of commonality in mechanism of ageing processes in vertebrates. At present, anatomical, cellular, biochemical and genetic evidences in support or against the occurrence of slow senescence or negligible senescence in long-lived fish species are almost nonexistent. Extensive studies on ageing in fishes are needed to explain the multiple mechanisms which are not unexpected considering the number and variety of the existing species.

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Section: Protein Metabolismsupporting

confidence: 55%

Ageing in Fishes

1994

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“…45 ! 45 cm) at a water temperature of 26 B 2°C and 12-hour light:12-hour dark cycle as described by Mahapatro and Patnaik [20].…”

Section: Animalsmentioning

confidence: 99%

Age-Related Effect of Aluminium on the Catalase Activities of the Brains of Two Species of Poikilothermic Vertebrates

Jena

Nayak²,

Patnaik

2002

Gerontology

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Background: Although aluminium (Al) has been implicated in various neuropathological states with aging due to its involvement in neurotoxicity, the exact role of the metal ion is still unclear. Objective: The aim of the present study is to ascertain whether the antioxidant enzymes of the brain protecting from oxidative damages which accumulate with aging are regulated by Al in an age-dependent manner. Method: The inhibitory effect of Al on the catalase activity of brain homogenates of two species of poikilothermic vertebrates was studied in vitro using a spectrophotometric method. Results: At a final concentration of 666 µM, the metal ion inhibited the enzyme activity of the brain in both species. In fish brain the degree of inhibition was not age-dependent. On the other hand, the rate of inhibition increased between young and middle-aged lizards followed by a decline in the old counterparts. Conclusion: Al inhibits catalase activity but this effect may not be a major contributing factor in the aging of the brain in the two species capable of maintaining their antioxidant capacity until old age.

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Nutrition and metabolism of glutamate and glutamine in fish

Zheng²,

2020

Amino Acids

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Age-dependent changes in some aspects of glutamate metabolism in the brain of the teleost, channa punctatus. I. Ammonia and glutamine contents and glutamate dehydrogenase activity

Cited by 6 publications

References 32 publications

Ageing in Fishes

Ageing in Fishes

Age-Related Effect of Aluminium on the Catalase Activities of the Brains of Two Species of Poikilothermic Vertebrates

Nutrition and metabolism of glutamate and glutamine in fish

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