Age-Dependent Changes in the Kidney Morphology of Female DBA/2 Mice

Yabuki, Akira; Yamato, Osamu; Suzuki, Syusaku

doi:10.1538/expanim.58.53

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…These findings were in accordance with Yabuki who had the opinion that the electron dense bodies contained acid phosphatase-positive matrix confirming an association between them and lysosomes. [30] Reactive oxygen species (ROS) are molecules with one or more unpaired electrons. A moderate amount of these radicals are formed endogenously as a result of physiological metabolic reactions.…”

Section: Discussionmentioning

confidence: 99%

Effect of Diabetes on the Rat Renal Cortex and the Possible Protective Role of Vitamins C and E

Ali¹,

Hulail²,

Hegazy³

et al. 2017

AIMDR

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Section: Discussionmentioning

confidence: 99%

Effect of Diabetes on the Rat Renal Cortex and the Possible Protective Role of Vitamins C and E

Ali¹,

Hulail²,

Hegazy³

et al. 2017

AIMDR

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“…The kidneys were analysed in respect to chronic progressive nephropathy, glomerulonephritis and amyloidosis and each part was scored according to severity [ 11 , 43 , 68 ]. The liver score was based on the frequency of the appearance of (a) lymphatic infiltration of the intrahepatic bile ducts, (b) parenchymla granuloma and (c) necrotising hepatitis [ 16 , 39 ].…”

Section: Methodsmentioning

confidence: 99%

Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length

et al. 2021

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Ageing provokes a plethora of molecular, cellular and physiological deteriorations, including heart failure, neurodegeneration, metabolic maladaptation, telomere attrition and hair loss. Interestingly, on the molecular level, the capacity to induce autophagy, a cellular recycling and cleaning process, declines with age across a large spectrum of model organisms and is thought to be responsible for a subset of age-induced changes. Here, we show that a 6-month administration of the natural autophagy inducer spermidine in the drinking water to aged mice is sufficient to significantly attenuate distinct age-associated phenotypes. These include modulation of brain glucose metabolism, suppression of distinct cardiac inflammation parameters, decreased number of pathological sights in kidney and liver and decrease of age-induced hair loss. Interestingly, spermidine-mediated age protection was associated with decreased telomere attrition, arguing in favour of a novel cellular mechanism behind the anti-ageing effects of spermidine administration.

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Female cotton rats (Sigmodon hispidus) develop chronic anemia with renal inflammation and cystic changes

Ichii

Nakamura

Irie

et al. 2016

Histochem Cell Biol

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The cotton rat (Sigmodon hispidus) is a laboratory rodent that has been used for studies on human infectious diseases. In the present study, we observed that female cotton rats, not the male cotton rats, developed chronic anemia characterized by reduced red blood cell, hemoglobin, and hematocrit levels from 5 to 9 months of age without any changes in the mean corpuscular hemoglobin and volume levels. In peripheral blood, the reticulocyte count did not increase in response to anemia in female cotton rats, and no extramedullary hematopoiesis was observed in the liver or spleen. Further, the serum levels of urea nitrogen and creatinine increased from 5 to 9 months of age in female cotton rats compared to male cotton rats, and these increases became more prominent from 10 months of age onward, indicating chronic kidney disease. Histopathologically, female cotton rats manifested tubulointerstitial lesions characterized by the infiltration of mononuclear cells, including plasma cells and CD3(+) T-cells, as well as the dilation of calbindin-D28k(+) distal tubules from 5 to 9 months of age. The severity of these lesions progressed from 10 months of age onward, and renal fibrotic features and numerous tubular cysts appeared without any obvious glomerular lesions. A significant decrease in the erythropoietin protein levels was observed in the kidney of aged female cotton rats, and significant correlations were detected between anemia and tubulointerstitial damage. These results suggest that aged female cotton rats chronically develop renal anemia, and this rodent may serve as a novel model to elucidate its pathogenesis.

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Age-Dependent Changes in the Kidney Morphology of Female DBA/2 Mice

Cited by 3 publications

References 9 publications

Effect of Diabetes on the Rat Renal Cortex and the Possible Protective Role of Vitamins C and E

Effect of Diabetes on the Rat Renal Cortex and the Possible Protective Role of Vitamins C and E

Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length

Female cotton rats (Sigmodon hispidus) develop chronic anemia with renal inflammation and cystic changes

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