Age-dependent changes of enzyme activities in the different fibre types of rat extensor digitorum longus and gastrocnemius muscles

Punkt, Karla; Krug, H; Huse, Jens; Punkt, Jürgen

doi:10.1016/s0065-1281(11)80395-8

Cited by 7 publications

(2 citation statements)

References 10 publications

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“…This fact supports the suggestion that the immature type II myofibers are a primitive form of types IIA and IIB and that IIA and IIB fibers may be interchangeable and also convertible into type I fibers [Suzuki and Cassens, 1980]. Biochemical observations have shown low activity of both glycolytic and oxidative enzymes in muscles of newborn and young animals and humans, compared to values in mature muscles [Lefaucheur and Vigneron, 1986;Punkt et al, 1993;Garry et al, 1996]. Similar further observations indicate that the inverse histochemical activity of glycolytic and oxidative enzymes, being typical of mature muscle fibers, does not exist in the same way in immature fibers [Davies, 1972;Dalrymple and Cassens, 1974].…”

Section: Development Of Muscle Fiber Type Patternssupporting

confidence: 78%

Muscle Growth and Fiber Type Composition in Hind Limb Muscles during Postnatal Development in Pigs

Wank

Fischer

Walter

et al. 2006

Cells Tissues Organs

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Rapid postnatal development in pigs is reflected by differentiation in skeletal muscle. This process depends on muscle function and demands, but a comprehensive overview of individual developmental characteristics of quickly growing leg muscles in pigs is still missing. This study focused on the development of 10 hind limb muscles in pigs. To determine these changes in mass, fiber type patterns and fiber diameters were analyzed 0, 2, 4, 7, 14, 28, 42, 56 and 400 days after birth. Generally, the proportion of slow fibers increased from birth to 8 weeks. Thereafter, only minor changes in muscle fiber type composition were observed. The majority of the muscles contained less then 10% slow-twitch fibers at birth, increasing to between 12 (Musculus vastus lateralis) and 38% (M. gastrocnemius medialis) in adult pigs. By contrast, postural muscles already had 20–30% slow fibers at birth, and this contribution increased up to 65% in adults (i.e. M. vastus intermedius). From birth to the 2nd week, only in slow fibers could activity of oxidative enzymes be detected. A differentiation of fast-twitch fibers into subtypes with high (comparable to type IIA) and low oxidative metabolism (equivalent to type IIB) occurred between the 2nd and 4th week of life. The ratio between type II fibers with high and low oxidative enzyme activity did not change markedly through development in any muscle, although there was a trend towards an increasing proportion of type IIA fibers in the soleus. In the majority of the muscles investigated, the fast-twitch fibers with low oxidative metabolism (IIB) obtained the largest cross-sectional area. In contrast, at birth no remarkable differences in the diameter of fast and slow fibers were found. The rapid increase in muscle mass compared to body mass reflects the high performance in meat production of the cross pig investigated.

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Section: Development Of Muscle Fiber Type Patternssupporting

confidence: 78%

Muscle Growth and Fiber Type Composition in Hind Limb Muscles during Postnatal Development in Pigs

Wank

Fischer

Walter

et al. 2006

Cells Tissues Organs

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“…Interestingly, fiber shifts in MyHC with aging are associated to a remodulation of these enzymatic activities. 19 Additional factors, such as the increase in resting muscle stiffness, affect age-related muscle impairment and will not be discussed here. 20…”

Section: Muscle Fiber Type and Fiber Shiftingmentioning

confidence: 99%

Exercise-mediated reinnervation of skeletal muscle in elderly people: An update

et al. 2022

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Sarcopenia is defined by the loss of muscle mass and function. In aging sarcopenia is due to mild chronic inflammation but also to fiber-intrinsic defects, such as mitochondrial dysfunction. Age-related sarcopenia is associated with physical disability and lowered quality of life. In addition to skeletal muscle, the nervous tissue is also affected in elderly people. With aging, type 2 fast fibers preferentially undergo denervation and are reinnervated by slow-twitch motor neurons. They spread forming new neuro-muscular junctions with the denervated fibers: the result is an increased proportion of slow fibers that group together since they are associated in the same motor unit. Grouping and fiber type shifting are indeed major histological features of aging skeletal muscle. Exercise has been proposed as an intervention for age-related sarcopenia due to its numerous beneficial effects on muscle mechanical and biochemical features. In 2013, a precursor study in humans was published in the European Journal of Translation Myology (formerly known as Basic and Applied Myology), highlighting the occurrence of reinnervation in the musculature of aged, exercise-trained individuals as compared to the matching control. This paper, entitled «Reinnervation of Vastus lateralis is increased significantly in seniors (70-years old) with a lifelong history of high-level exercise», is now being reprinted for the second issue of the «Ejtm Seminal Paper Series». In this short review we discuss those results in the light of the most recent advances confirming the occurrence of exercise-mediated reinnervation, ultimately preserving muscle structure and function in elderly people who exercise.

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Age-dependent mechanical and microstructural properties of the rabbit soleus muscle

et al. 2021

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Age-dependent changes of enzyme activities in the different fibre types of rat extensor digitorum longus and gastrocnemius muscles

Cited by 7 publications

References 10 publications

Muscle Growth and Fiber Type Composition in Hind Limb Muscles during Postnatal Development in Pigs

Muscle Growth and Fiber Type Composition in Hind Limb Muscles during Postnatal Development in Pigs

Exercise-mediated reinnervation of skeletal muscle in elderly people: An update

Age-dependent mechanical and microstructural properties of the rabbit soleus muscle

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