2018
DOI: 10.1111/joa.12868
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Age‐dependent changes of the mandible bone throughout the lifespan in female F344/N rat

Abstract: Age-dependent changes of the mandible bone in female F344/N rats, aged 22-1196 days, were analyzed using physiological bone properties and morphology. Bone weight, bone area, bone mineral components, and bone mineral density were assessed using dual-energy X-ray absorptiometry. The bone weight, bone area, bone mineral components, and bone mineral density increased rapidly until approximately 150 days of age, increased gradually thereafter, and then stabilized or decreased after 910 days of age. The ratio of bo… Show more

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Cited by 3 publications
(4 citation statements)
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“…The length of time (1.5–2 years) it took for the bone parameters (BnW, BMC and AREA) to reach their peak corresponds almost exactly to one tenth of the common marmoset’s entire lifespan (around 20 Y [ 6 ]). In a female-inbred strain of rats (F344/NSlc), the bone parameters of the mandibles increase steeply until three months of age [ 11 ], which also corresponds to one tenth of the lifespan of this strain [ 20 ]. This suggests that bone maturity requires one tenth of the lifespan of both simians and rodents.…”
Section: Discussionmentioning
confidence: 99%
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“…The length of time (1.5–2 years) it took for the bone parameters (BnW, BMC and AREA) to reach their peak corresponds almost exactly to one tenth of the common marmoset’s entire lifespan (around 20 Y [ 6 ]). In a female-inbred strain of rats (F344/NSlc), the bone parameters of the mandibles increase steeply until three months of age [ 11 ], which also corresponds to one tenth of the lifespan of this strain [ 20 ]. This suggests that bone maturity requires one tenth of the lifespan of both simians and rodents.…”
Section: Discussionmentioning
confidence: 99%
“…The decrease in BMD thus started immediately after the end of the growth phase. In contrast, BMD in F344/NSlc rat increase continuously until 30 months of age, which corresponds to eight tenth of its lifespan [ 11 ]. In human, BMD reach the peak by 30 Y, and consistently decreased thereafter [ 9 , 21 , 22 ] which is similar to the case in common marmoset rather than rat.…”
Section: Discussionmentioning
confidence: 99%
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“…La mandíbula rata es una de las estructuras anatómicas de mayor interés en la investigación básica o preclínica en las ciencias odontológicas, sobre todo en aquellas áreas relacionadas con la regeneración ósea, implantología y el desarrollo de biomateriales (Dereka et al, 2018). Otro ámbito en el que el estudio de la mandíbula resulta esencial es en la investigación del estado nutricional y cambios relacionados con la edad, pues los dientes, el desgaste oclusal y la morfología ósea, son un buen indicador del estado fisiológico del sistema masticatorio (Nishijima et al, 2018).…”
Section: Introductionunclassified