Age‑dependent decrease of Nurr1 protein expression in the gerbil hippocampus

Ahn, Ji Hyeon; Lee, Joon Seok; Cho, Jun Hwi; Park, Joon Ha; Lee, Tae‐Kyeong; Song, Minah; Kim, Hyun-Jung; Kang, Seok Hoon; Won, Moo‐Ho; Lee, Choong Hyun

doi:10.3892/br.2018.1094

Cited by 9 publications

(9 citation statements)

References 41 publications

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“…For instance, it was reported that p53 and p63 are reduced age-dependently in mouse hippocampus, which might be closely involved in cellular senescence [ 12 ]. Ahn et al (2019) demonstrated that, in gerbil hippocampus, expression of nuclear receptor related-1 protein, which is considered as deeply connected with cognitive function, was reduced with the advance of age [ 13 ]. In addition, Lee et al (2018) showed age-dependent decrease in the expressions of insulin-like growth factor (IGF) I and its receptor in gerbil olfactory bulb [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…Aging is an unavoidable process for almost living things and leads to detrimental changes in macromolecules and cells, which can elevate the risk of exposure to senile diseases [ 9 ]. Numerous studies have demonstrated that aging is one of major causes inducing neurochemical and neurophysiological alterations in various substructures of the brain, including the hippocampus [ 10 – 13 ]. Among the factors related with the aging process, reactive oxygen species (ROS) are regarded a key factor to engage brain aging [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of age‐dependent alterations in thioredoxin 2 and thioredoxin reductase 2 expressions in hippocampi between mice and rats

et al. 2021

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Background Aging is one of major causes triggering neurophysiological changes in many brain substructures, including the hippocampus, which has a major role in learning and memory. Thioredoxin (Trx) is a class of small redox proteins. Among the Trx family, Trx2 plays an important role in the regulation of mitochondrial membrane potential and is controlled by TrxR2. Hitherto, age-dependent alterations in Trx2 and TrxR2 in aged hippocampi have been poorly investigated. Therefore, the aim of this study was to examine changes in Trx2 and TrxR2 in mouse and rat hippocampi by age and to compare their differences between mice and rats. Results Trx2 and TrxR2 levels using Western blots in mice were the highest at young age and gradually reduced with time, showing that no significant differences in the levels were found between the two subfields. In rats, however, their expression levels were the lowest at young age and gradually increased with time. Nevertheless, there were no differences in cellular distribution and morphology in their hippocampi when it was observed by cresyl violet staining. In addition, both Trx2 and TrxR2 immunoreactivities in the CA1-3 fields were mainly shown in pyramidal cells (principal cells), showing that their immunoreactivities were altered like changes in their protein levels. Conclusions Our current findings suggest that Trx2 and TrxR2 expressions in the brain may be different according to brain regions, age and species. Therefore, further studies are needed to examine the reasons of the differences of Trx2 and TrxR2 expressions in the hippocampus between mice and rats.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of age‐dependent alterations in thioredoxin 2 and thioredoxin reductase 2 expressions in hippocampi between mice and rats

et al. 2021

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“…NURR1 is a transcription factor that regulates the development of DA precursors into mature DA neurons (31). In NURR1-deficient mice, DA dysfunction occurs during ageing (32)(33)(34). Therefore, NURR1 is considered to be a PD candidate gene (35).…”

Section: Discussionmentioning

confidence: 99%

Wnt1 silencing enhances neurotoxicity induced by paraquat and maneb in SH‑SY5Y cells

Huang

et al. 2019

Exp Ther Med

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Wingless (Wnt) signaling regulates the proliferation and differentiation of midbrain dopamine (DA) neurons. Paraquat (PQ) and maneb (MB) are environmental pollutants that can be used to model Parkinson's disease (PD) in rodents. A previous study demonstrated that developmental exposure to PQ and MB affects the expression of Wnt1, Wnt5a, nuclear receptor-related factor 1 (NURR1) and tyrosine hydroxylase (TH). However, how Wnt signaling regulates these developmental factors in vitro is yet to be determined. To explore this, SH-SY5Y cells were exposed to PQ and MB. The results of the current study indicated that exposure to PQ and MB decreased Wnt1, β-catenin, NURR1 and TH levels and increased Wnt5a levels. Furthermore, Wnt1 silencing has the same effect as exposure to PQ and MB. Additionally, the neurotoxicity induced by PQ and MB is more severe in siWnt1-SH-SY5Y cells compared with normal SH-SY5Y cells. Therefore, Wnt1 may serve an important role in regulating developmental DA factors, and may be a candidate gene for PD diagnosis or gene therapy.

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“…Furthermore, in vivo studies showed that Nurr1deficient mice exhibited deficits in the differentiation of dopaminergic neurons in the ventral midbrain [78,150]. In support of this notion, Nurr1 is not only well known to play a key role in the differentiation and maturation of dopaminergic neurons [151][152][153][154][155] but may also exert an important role in neurogenesis [156]. These studies suggest that Nurr1 may contribute to the rescue of impaired adult neurogenesis in AD.…”

Section: Neurogenic Effects Of Nurr1 In the Adult Brainmentioning

confidence: 96%

The Critical Role of Nurr1 as a Mediator and Therapeutic Target in Alzheimer’s Disease-related Pathogenesis

et al. 2020

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Several studies have revealed that the transcription factor nuclear receptor related 1 (Nurr1) plays several roles not only in the regulation of gene expression related to dopamine synthesis, but also in alternative splicing, and miRNA targeting. Moreover, it regulates cognitive functions and protects against inflammationinduced neuronal death. In particular, the role of Nurr1 in the pathogenesis of Parkinson's disease (PD) has been well investigated; for example, it has been shown that it restores behavioral and histological impairments in PD models. Although many studies have evaluated the connection between Nurr1 and PD pathogenesis, the role of Nurr1 in Alzheimer's disease (AD) remain to be studied. There have been several studies describing Nurr1 protein expression in the AD brain. However, only a few studies have examined the role of Nurr1 in the context of AD. Therefore, in this review, we highlight the overall effects of Nurr1 under the neuropathologic conditions related to AD. Furthermore, we suggest the possibility of using Nurr1 as a therapeutic target for AD or other neurodegenerative disorders.

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Age‑dependent decrease of Nurr1 protein expression in the gerbil hippocampus

Cited by 9 publications

References 41 publications

Comparison of age‐dependent alterations in thioredoxin 2 and thioredoxin reductase 2 expressions in hippocampi between mice and rats

Comparison of age‐dependent alterations in thioredoxin 2 and thioredoxin reductase 2 expressions in hippocampi between mice and rats

Wnt1 silencing enhances neurotoxicity induced by paraquat and maneb in SH‑SY5Y cells

The Critical Role of Nurr1 as a Mediator and Therapeutic Target in Alzheimer’s Disease-related Pathogenesis

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