Age-dependent differences in borderline ovarian tumours (BOT) regarding clinical characteristics and outcome: results from a sub-analysis of the Arbeitsgemeinschaft Gynaekologische Onkologie (AGO) ROBOT study

Trillsch, Fabian; Mahner, Sven; Woelber, Linn; Vettorazzi, Eik; Reuß, Alexander; Ewald-Riegler, Nina; Gregorio, Nikolaus de; Fotopoulou, Christina; Schmalfeldt, Barbara; Burges, Alexander; Hilpert, Felix; Fehm, Tanja; Meier, W.; Hillemanns, Peter; Hanker, Lars; Hasenburg, Annette; Strauß, Hans‐Georg; Hellriegel, Martin; Wimberger, Pauline; Baumann, Klaus; Keyver-Paik, Mignon; Canzler, Ulrich; Wollschlaeger, K.; Forner, Dirk Michael; Pfisterer, Jacobus; Schroeder, W.; Muenstedt, Karsten; Richter, Barbara; Kommoss, Friedrich; Hauptmann, Steffen; Bois, Andreas du

doi:10.1093/annonc/mdu119

Cited by 66 publications

(61 citation statements)

References 17 publications

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“…However, they observed a higher risk for invasive progression in older patients. 5 Our series of 132 patients confirmed the excellent overall prognosis of BOT with an OS rate of 96% at 5 years and 91% at 10 years with a mean follow-up time of 6 years. Of the 7 patients who died, 1 patient died of relapsed BOT and 1 patient died of a relapse as low-grade invasive carcinoma.…”

Section: Discussionsupporting

confidence: 75%

“…Similar findings were reported in other studies. 2,5,14 We found a higher FIGO stage (III), peritoneal implants, bilateral BOT, residual disease, fertility preservation, and a younger age (e40 years) to be prognostic factors for disease recurrence. There is a trend for a higher risk for patients with micropapillary type at primary diagnosis.…”

Section: Discussionmentioning

confidence: 81%

“…3 One third of the patients diagnosed with BOTs are younger than 40 years with an average age of 42 years for serous BOT. 1,4,5 Therefore, fertilitypreserving surgery (FPS) has become an important issue. 5 The overall survival (OS) of serous BOTs is excellent with 5-year survival rates between 88% and greater than 95% for International Federation of Gynecology and Obstetrics (FIGO) stages I to IIIB.…”

mentioning

confidence: 99%

“…1,4,5 Therefore, fertilitypreserving surgery (FPS) has become an important issue. 5 The overall survival (OS) of serous BOTs is excellent with 5-year survival rates between 88% and greater than 95% for International Federation of Gynecology and Obstetrics (FIGO) stages I to IIIB. 1 Despite these favorable data, approximately 11% of the patients with BOT relapse, with a risk for invasive recurrence of 2% to 4%.…”

mentioning

confidence: 99%

“…2 Fertility-preserving surgery and younger age are risk factors for recurrence. 5,6 However, little is known about the risk of invasive recurrence, and hence, the impact of FPS on OS. 6 The aim of this study was to determine the OS and progression-free survival (PFS) and the influence of FPS in a large group of patients with serous BOT, diagnosed by one pathologist and treated by the same team during the accrual period.…”

mentioning

confidence: 99%

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Fertility Preservation Is Safe for Serous Borderline Ovarian Tumors

Vancraeynest

Moerman²,

Leunen³

et al. 2016

Int J Gynecol Cancer

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Objectives: This study aimed to determine the overall survival (OS) and progression-free interval and the influence of fertility-preserving surgery (FPS) versus radical surgery (RS) in patients with serous borderline ovarian tumor (BOT). Methods: Clinical parameters of patients with serous BOT treated between 1993 and 2013 in one institution were retrospectively investigated. All tumors were examined by one pathologist with experience in gynecological pathology. Results: One hundred thirty-two patients with serous BOT (inclusive 16 microinvasive) were analyzed (45% were e40 years), with a median follow-up of 6 years. Thirty-two percent (42/132) of the patients received FPS; 14% (18/132) relapsed (invasive or borderline). The 5-year progression-free survival was 89%. The risk of recurrence was higher in patients 40 years or younger (P = 0.019), after FPS (P = 0.002), in patients with a higher International Federation of Gynecology and Obstetrics (FIGO) stage (P = 0.016), for bilateral BOT (P = 0.0132), and for the micropapillary variant (P = 0.067). The OS at 5 years was 97%. There was no statistically significant difference in OS between FPS and RS [all (6 of 90) patients, except for 1, with RS died]. One patient died of relapsed BOT. Among the recurrences, low-grade invasive carcinoma was diagnosed in 4 patients. Three of these 4 patients were originally operated radically, 2 had a micropapillary variant FIGO stage III, and 1 had a papillary pattern FIGO stage II with microinvasion; all 3 had noninvasive implants and are alive. One patient with a micropapillary variant, FIGO stage IIIC with microinvasion and invasive implants, received FPS and died of disease. Conclusions: The risk of recurrence is higher after FPS compared with RS; however, no influence on OS was observed. This was because most of the patients relapsed as BOT. Fertility preservation is justified in young patients with serous borderline tumors.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 81%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Fertility Preservation Is Safe for Serous Borderline Ovarian Tumors

Vancraeynest

Moerman²,

Leunen³

et al. 2016

Int J Gynecol Cancer

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Epithelial ovarian cancer subtypes attributable to smoking in the Norwegian Women and Cancer Study, 2012

et al. 2016

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Among European women, ovarian cancer is the fifth most common cancer. Smoking is an established risk factor for mucinous tumors. We estimated the impact of smoking in Norwegian women using population attributable fractions (PAFs) of epithelial ovarian cancer (EOC), by invasiveness and by histological subtypes in the Norwegian Women and Cancer Study with an average of 13.2 years of follow‐up. During >2 million person‐years, a total of 915 incident EOC cases, of which 667 (73%) invasive and 248 (27%) borderline, were identified among 154,234 women aged 34–70 years at enrolment. Compared with never smokers, current smokers had a nonstatistically significant increased risk of mucinous tumors (hazard ratio [HR] = 1.67 [95% confidence interval, (CI), 0.96–2.96]) and more than twice statistically significant risk of borderline mucinous tumors (HR = 2.17 [95% CI, 1.06–4.45]). The corresponding PAF estimates were 16.5% for mucinous and 25% for borderline mucinous. We found that among middle‐aged women, one in six mucinous tumors and one in four borderline mucinous tumors could have been prevented if women did not smoke.

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Sporadic Ovarian and Fallopian Tube Cancer in Postmenopausal Women

Pérez‐López

2019

Postmenopausal Diseases and Disorders

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Age-dependent differences in borderline ovarian tumours (BOT) regarding clinical characteristics and outcome: results from a sub-analysis of the Arbeitsgemeinschaft Gynaekologische Onkologie (AGO) ROBOT study

Cited by 66 publications

References 17 publications

Fertility Preservation Is Safe for Serous Borderline Ovarian Tumors

Fertility Preservation Is Safe for Serous Borderline Ovarian Tumors

Epithelial ovarian cancer subtypes attributable to smoking in the Norwegian Women and Cancer Study, 2012

Sporadic Ovarian and Fallopian Tube Cancer in Postmenopausal Women

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