Age-dependent Effect of Metabolism and Testicular Toxicity to di(2-ethylhexyl) Phthalate

박영주,; ChoiByungSun,; 홍연표,; ParkJungDuck,

doi:10.35371/kjoem.2002.14.3.236

Cited by 3 publications

(2 citation statements)

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“…Several studies have shown that DEHP can potentially damage the reproductive system [35][36][37]. Recently, a plausible association between DEHP and metabolic disorders, including obesity, diabetes mellitus, and thyroid dysfunction, has been suggested [32,38,39].…”

Section: Discussionmentioning

confidence: 99%

Short-term exposure to di(2-ethylhexyl)phthalate may disrupt hepatic lipid metabolism through modulating the oxidative stress in male adolescent rats

Lee,

Hong,

Yang

2024

Environ Anal Health Toxicol

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Di(2-ethylhexyl)phthalate (DEHP) is commonly used to increase the flexibility of plastics. In our previous study, DEHP may increase hepatic lipid accumulation through modulating of acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) expression. Nevertheless, it is hard to understand the association between DEHP and DGAT1 in the liver because only one dosage of DEHP was used. Thus, this study performed to investigate the role of DGAT1 on hepatic lipid metabolism after various dosages of DEHP exposure. Four-week-old male Sprague-Dawley rats (n = 5/group) were administered corn oil (vehicle) or DEHP (0.75, 7.5, 15, or 150 mg/kg/day) once daily for seven days. DEHP 150 mg/kg/day treated group increased body weight gain and relative liver weight compared to the control (P = 0.044 and P = 0.049, respectively). In histological observation, elevation of hepatic lipid accumulation was observed in all DEHP-treated groups, except DEHP 150 mg/kg/day, compared to that in the control (all P < 0.001). Portal inflammatory infiltration and acidophilic bodies were observed in the liver at DEHP 7.5 mg/kg/day and above treated groups. In addition, malondiadehyde levels, a marker of lipid peroxidation, in the liver were increased in DEHP 7.5, 15 and 150 mg/kg/day compared to the control (P = 0.017, P = 0.001, and P = 0.002, respectively). The expression of Dgat1 in the liver was significantly increased in DEHP 7.5, 15 and 150 mg/kg/day compared to the control group (P = 0.019, P = 0.002, and P < 0.001, respectively); however, there were no significant changes in the protein levels. Therefore, excessive oxidative stress caused by DEHP may induce liver damage such as inflammation rather than hepatic lipid accumulation by regulating DGAT1 transcription.

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Section: Discussionmentioning

confidence: 99%

Short-term exposure to di(2-ethylhexyl)phthalate may disrupt hepatic lipid metabolism through modulating the oxidative stress in male adolescent rats

Lee,

Hong,

Yang

2024

Environ Anal Health Toxicol

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“…While most studies have been focused on the reproductive toxicity of DEHP exposure (Akingbemi et al, 2001;Park et al, 2002;Lyche et al, 2009), the plausible association between DEHP and metabolic disorders, including obesity, diabetes mellitus, and hepatic lipid accumulation has been raised (Gayathri et al, 2004;Martinelli et al, 2006;An et al, 2021). In epidemiological studies, the association has also been reported between phthalates levels and the occurrence of metabolic disorders, including abdominal obesity and insulin resistance (Stahlhut et al, 2007), and nonalcoholic fatty liver disease (Yang et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

The Impairment of Thyroid Hormones Homeostasis after Short-Term Exposure to Di(2-ethylhexyl)phthalate in Adolescent Male Rats

Kim¹,

Hong²,

Yang³

2021

Dev. Reprod.

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phthalate (DEHP) could induce metabolic disorders through interfering with thyroid homeostasis. Therefore, we evaluated the effects of short term to environmental relevant doses of DEHP on thyroid hormones. Four week old Sprague-Dawley (SD) rats were treated with vehicle (corn oil), and DEHP 0.75, 7.5, and 150 mg/kg/day. The rats were treated with once daily by oral gavage and were sacrificed with after 1 week. They were measured body weight and relative thyroid weight, serum thyroid hormones and histological changes of thyroid. There was no difference in body weight between the control and DEHP exposed rats. Relative thyroid weight in DEHP 150 mg/kg/day treated group was significantly lower than control. Serum thyroxine levels was decreased in rats exposed to 0.75 and 150 mg/kg/day DEHP. No histological changes were observed in the thyroid of rats administered DEHP compared to control. Exposure to DEHP at environmental relevant levels, even shortterm exposure, can cause hypothyroidism in adolescent rats even the exposure period is relative short.

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Validation of High Performance Liquid Chromatographic Method with UV Detector for the Determination of Di(2-ethylhexyl)Phthalate in Plasma in some Korean Male Workers

Yang

Myoung

Kim

et al. 2005

Korean J Occup Environ Med

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Age-dependent Effect of Metabolism and Testicular Toxicity to di(2-ethylhexyl) Phthalate

Cited by 3 publications

References 0 publications

Short-term exposure to di(2-ethylhexyl)phthalate may disrupt hepatic lipid metabolism through modulating the oxidative stress in male adolescent rats

Short-term exposure to di(2-ethylhexyl)phthalate may disrupt hepatic lipid metabolism through modulating the oxidative stress in male adolescent rats

The Impairment of Thyroid Hormones Homeostasis after Short-Term Exposure to Di(2-ethylhexyl)phthalate in Adolescent Male Rats

Validation of High Performance Liquid Chromatographic Method with UV Detector for the Determination of Di(2-ethylhexyl)Phthalate in Plasma in some Korean Male Workers

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